IgG4 disease is an immune-mediated disorder characterized by fibroinflammatory masses that can infiltrate multiple organ systems. Renal involvement is considered one of the key features of this disease. Report 02 case...
supported by grants from the National Nature Science Foundation of China(No.82073928,82104184);the Leading technology foundation research project of Jiangsu province(BK20232035,BK20192005);Natural Science Foundation of Jiangsu Province(BK20220149);the Key Program of National Natural Science Foundation of China(No.81930043);the Jiangsu Provincial Key Research and Development Program(BE2020621);Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00005);Nanjing Scientific and Technological Special Project for Life and Health(No.202110006);the Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University(No.SKLNMZZ202302);Fundamental Research Funds for the Central Universities(No.2632023TD03).
Human umbilical cord mesenchymal stem cells(hUC-MSCs)have shown potential as a therapeutic option for lupus nephritis(LN),particularly in patients refractory to conventional treatments.Despite extensive translational ...
supported by grants from the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation),Project-ID 431984000-CRC 1453 to FA,CS,and YT,Project-ID 256073931-CRC 1160 to S,CS,and YT,Project-IDs 491676693-TRR359,and 322977937-GRK 2344 to S,Project-IDs 241702976,438496892,501370692,and 386793560-CRU 329 to CS,the Else Kröner-Fresenius-Stiftung(2016_Kolleg.03),Bad Homburg,Germany to FA,the Berta-Ottenstein-Programme for Clinician Scientists,Faculty of Medicine,University of Freiburg,Germany to FA,the Research Commission of the Faculty of Medicine,University of Freiburg,Germany to FA,the MOTI-VATE Doctoral College,Faculty of Medicine,University of Freiburg,Germany to LK,the Wilhelm Sander-Stiftung(Wilhelm Sander Foundation)to CS.The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript.Open Access funding enabled and organized by Projekt DEAL.
Immune-mediated nephritis is a leading cause of acute kidney injury and chronic kidney disease.While the role of B cells and antibodies has been extensively investigated in the past,the advent of immune-checkpoint inh...
Objective To investigate the extraglomerular deposition of C1q in patients with lupus nephritis (LN)and explore its clinicopathological significance,and to provide immunological evidence for the mechanism of renal tub...
National Key Research and Development Program of China(2021YFC2501304);Science and Technology Program of Department of Health of Jiangxi Province(20204254);Key Research and Development Program of Jiangxi Municipal Science and Technology Department(20192BBGL70024).
To the Editor,Lupus nephritis(LN),a renal symptom of systemic lupus erythematosus(SLE),frequently causes severe organ damage in SLE patients.1 There is no consensus on the definition of refractory LN,which has been su...
Background:Lupus nephritis(LN)results in high morbidity and mortality in patients with systemic lupus erythematosus.Refractory cases of standard immunosuppressive therapy have been recorded.Mesenchymal stem cell trans...
The clinical spectrum of immunoglobulin A vasculitis nephritis(IgAVN)ranges from the relatively common transitory microscopic hematuria and/or low-grade proteinuria to nephritic or nephrotic syndrome,rapidly progressi...
Hunan Provincial Health Commission of China(No.20200558);Natural Science Foundation of Hunan Province of China(No.2020JJ4408)
Case presentation A 42-year-old female presented with frequent urination,thirst and pain on the left flank of 20 days"duration.The vital signs on admission were as follows:body temperature,36.5℃;pulse,91/min;blood pr...
the National Natural Science Foundation of China(No.82070770);the Natural Science Foundation of Guangdong Province(No.2020A1515010674);the Science and Technology Planning Project of Guangzhou(No.201803010109);the President Funding of Nanfang Hospital(Nos.2018B009 and 2018C003);the College Students’Innovative Entrepreneurial Training Plan Program(Nos.X202012121239,202012121046)。
To the Editor:Acute lobar nephronia(ALN),also known as acute focal bacterial nephritis,is a severe form of upper urinary tract infection(UTI)that is characterized by the presence of an inflammatory mass lesion in the ...
The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine(No.2020XKTD-A04);Disciplinary Innovation Team Plan of Shaanxi University of Traditional Chinese Medicine(No.2019-QN02)。
Objective:To systematically evaluate the efficacy and safety of Nephritis Rehabilitation Tablet(NRT)combined with valsartan in treatment of chronic glomerulonephritis(CGN).Methods:Computer search databases such as CNK...