IgG4 Disease Revealed by Renal Damage: Report of a Series of Cases  

作　　者：N’Guessan Michel Konan Pascal Sanou Manzan Edwige Anastasie Wognin Tiepe Rokia Ouattara Georges Stéphane Koffi Jean-Fiacre Lidwine Abbot Christ Zahe Reine Marie Koffi Abdoul Yannick Gonan Kehi Jonathan Kpan Ahua N’Seliosseh Sébastienne Yao Weu Mélanie Tia Yao Hubert Kouamé Bourahima Ouattara Lionel Rostaing N’Guessan Michel Konan;Pascal Sanou;Manzan Edwige Anastasie Wognin;Tiepe Rokia Ouattara;Georges Stéphane Koffi;Jean-Fiacre Lidwine Abbot;Christ Zahe Reine Marie Koffi;Abdoul Yannick Gonan;Kehi Jonathan Kpan;Ahua N’Seliosseh Sébastienne Yao;Weu Mélanie Tia;Yao Hubert Kouamé;Bourahima Ouattara;Lionel Rostaing(Department of Internal Medicine and Digestive Endoscopy, Treichville Teaching Hospital, Medical Sciences Training of Research Unit, Flix Houphout Boigny University, Abidjan, Ivory Coast;Department of Nephrology, Hemodialysis, Apheresis and Renal Transplantation, Grenoble Teaching Hospital, Grenoble, France;Department of Internal Medicine, Nephrology, Hemodialysis, Bouake Teaching Hospital, Medical Sciences Training and Research Unit, Alassane Ouattara University, Abidjan, Ivory Coast;Department of Nephrology, Hemodialysis, Treichville Teaching Hospital, Medical Sciences Training and Research Unit, Felix Houphouet Boigny University, Abidjan, Ivory Coast)

机构地区：[1]Department of Internal Medicine and Digestive Endoscopy, Treichville Teaching Hospital, Medical Sciences Training of Research Unit, Flix Houphout Boigny University, Abidjan, Ivory Coast [2]Department of Nephrology, Hemodialysis, Apheresis and Renal Transplantation, Grenoble Teaching Hospital, Grenoble, France [3]Department of Internal Medicine, Nephrology, Hemodialysis, Bouake Teaching Hospital, Medical Sciences Training and Research Unit, Alassane Ouattara University, Abidjan, Ivory Coast [4]Department of Nephrology, Hemodialysis, Treichville Teaching Hospital, Medical Sciences Training and Research Unit, Felix Houphouet Boigny University, Abidjan, Ivory Coast

出　　处：《Open Journal of Internal Medicine》2024年第4期329-336,共8页内科学期刊(英文)

摘　　要：IgG4 disease is an immune-mediated disorder characterized by fibroinflammatory masses that can infiltrate multiple organ systems. Renal involvement is considered one of the key features of this disease. Report 02 cases of IgG4 disease with renal manifestations revealing the disease such as extramembranous glomerulonephritis and tubulointerstitial nephritis rich in polytypic IgG4+ plasma cells. Associated renal parenchymal lesions concomitant with multiple organ involvement should help improve early recognition of IgG4-RKD disease (IgG4-RKD). In our case series, prednisone was the treatment of choice;the use of rituximab in extramembranous glomerulonephritis had resulted in remission of the disease.IgG4 disease is an immune-mediated disorder characterized by fibroinflammatory masses that can infiltrate multiple organ systems. Renal involvement is considered one of the key features of this disease. Report 02 cases of IgG4 disease with renal manifestations revealing the disease such as extramembranous glomerulonephritis and tubulointerstitial nephritis rich in polytypic IgG4+ plasma cells. Associated renal parenchymal lesions concomitant with multiple organ involvement should help improve early recognition of IgG4-RKD disease (IgG4-RKD). In our case series, prednisone was the treatment of choice;the use of rituximab in extramembranous glomerulonephritis had resulted in remission of the disease.

关 键 词：IgG4 Disease Extramembranous Glomerulonephritis Tubulo-Nephritis Interstitial Corticotherapie RITUXIMAB 

分 类 号：R57[医药卫生—消化系统]