Focal segmental glomerulosclerosis(FSGS)is a histological pattern of glomerular damage that significantly contributes to chronic kidney disease and end-stage renal disease.Its incidence is rising globally,necessitatin...
BACKGROUND Cytomegalovirus(CMV)infections can cause significant morbidity and mortality in immunocompromised individuals.CMV targets dysfunctional lymphocytes.Chronic rituximab(RTX)therapy can cause B-lymphocyte dysfu...
BACKGROUND Autoimmune hepatitis(AIH)is typically treated with immunomodulators and steroids.However,some patients are refractory to these treatments,necessitating alternative approaches.Biological therapies have recen...
Background: Patients with Steroid-Refractory Idiopathic Minimal change disease (SRIM) have high morbidity and mortality and inherent side effects of immunosuppressive therapy. Except for its cost, R has been shown to ...
IgG4 disease is an immune-mediated disorder characterized by fibroinflammatory masses that can infiltrate multiple organ systems. Renal involvement is considered one of the key features of this disease. Report 02 case...
Objective To investigate the efficacy and prognosis of rituximab(RTX)in the treatment of M-type phospholipase A2 receptor(PLA2R)-associated idiopathic membranous nephropathy(IMN).Methods It was a retrospective cohort ...
https://doi.org/10.1038/s41392-024-01941-x Fujian Provincial Health Technology Project[grant number 2023CXA028];Joint Funds for the Innovation of Science and Technology,Fujian Province(grant number 2023Y9021);National Science Foundation of Fujian Province[grant number 2022J02036];Clinical research project of Wu Jieping Medical Foundation[grant number 320.6750.19094-41];National Natural Science Foundation of China[grant number 82070218,81400160].
Primary central nervous system lymphoma(PCNSL)is a rare and frequently fatal lymphoma subtype.The programmed death-1(PD-1)pathway has emerged as a potential therapeutic target,but the effectiveness of PD-1 antibody si...
Rituximab is a monoclonal antibody that targets CD20, which is a specific B-cell surface antigen. It was the first monoclonal antibody that was approved for the treatment of non-Hodgkin lymphoma, rheumatoid arthritis,...
Supported by Ministry of Science and Higher Education of the Russian Federation,No.075-15-2022-301;the Russian Science Foundation Grant,No.22-45-08004.
BACKGROUND Juvenile systemic lupus erythematosus(SLE)is a severe,life-threatening disease.However,the role of rituximab in managing juvenile SLE remains undefined,although early biological intervention may improve dis...
To the Editor,Anti-melanoma differentiation-associated gene 5(anti-MDA5)antibody-associated dermatomyositis(DM)presenting with rapidly progressive interstitial lung disease(RP-ILD)is extremely challenging to treat.MDA...