云南高校图书馆联盟文献共享服务平台- METHOTREXATE

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Psoriasis,metabolic syndrome and methotrexate:Is this association suitable for a new subcategory in steatotic liver disease?: 《World Journal of Hepatology》2025年第4期11-18,共8页Luciana Agoglia Maria Chiara Chindamo Cristiane Villela-Nogueira; Psoriasis is a prevalent inflammatory disease that shares chronic inflammation pathways with the pathophysiology of metabolic syndrome(MetS),type-2 diabetes mellitus and atherosclerosis.A high prevalence of steatosis ...; 关键词：PSORIASIS Genetic polymorphisms METHOTREXATE Metabolic dysfunctionassociated steatotic liver disease Liver fibrosis Transient elastography

Coffee-derived self-anti-inflammatory polymer as drug nanocarrier for enhanced rheumatoid arthritis treatment: 《Chinese Chemical Letters》2025年第3期371-378,共8页Chunlei Dai Liying Wang Xinru You Yi Zhao Zhong Cao Jun Wu; supported by the National Natural Science Foundation of China(No.52173150);the Guangzhou Science and Technology Program City University Joint Funding Project(No.2023A03J0001)to Jun Wu;supported by the National Natural Science Foundation of China(No.52073313);Shenzhen Science and Technology Program(No.KCXFZ 202002011010232);Longhua District Science and Innovation Commission Project Grants of Shenzhen(No.10162A20221027B1FA526)to Zhong Cao;supported by Shenzhen Medical Research Fund(No.A2303010);National Natural Science Foundation of China(No.82204287);Fundamental Research Funds for the Central Universities,Sun Yat-sen University(No.87000-31670001)to Yi Zhao;supported by Guangdong Basic and Applied Basic Research Foundation(No.2023A1515220126)to Xinru You。; Systemic administration of the anti-rheumatic drug methotrexate(MTX)for a long period of time may lead to therapeutic tolerance,various adverse effects,and potential harm to the immune system.Therapeutic nano-delivery...; 关键词：Rheumatoid arthritis Caffeic acid Self-anti-inflammatory polymer NANOCARRIER METHOTREXATE

Efficacy and Safety of Juan Bi Pill with Add-on Methotrexate in Active Rheumatoid Arthritis:A 48-Week,Multicentre,Randomized,Double-Blind,and Placebo-Controlled Trial: 《Chinese Journal of Integrative Medicine》2025年第2期99-107,共9页JIA Qing-yun WANG Yi-ru SUN Da-wei MAO Jian-chun XUE Luan GU Xiao-hua YU Xiang PIAO Xue-mei XU Hao LIANG Qian-qian; Supported by National Natural Science Foundation of China(Nos.81920108032,81822050);State Administration of Traditional Chinese Medicine Young Qi Huang Scholar,Shanghai Science and Technology Innovation Action Plan Medical Innovation Research Project(No.21Y11921400);Innovation Team Project of Scientific Research Project of Traditional Chinese Medicine of Shanghai Health Committee(No.2022CX001);the Program for Innovative Research Team of Ministry of Science and Technology of China(No.2015RA4002);"Innovation Team"Development Projects(No.IRT1270);Shanghai TCM Medical Center of Chronic Disease(No.2022ZZ01009);Shandong Provincial Natural Science Foundation(Nos.ZR2022LZY002 and ZR2021QH230)。; Objective:To explore the efficacy and safety of Juan Bi Pill(JBP)in treatment of active rheumatoid arthritis(RA).Methods:From February 2017 to May 2018,115 participants from 4 centers were randomly divided into JBP gr...; 关键词：Chinese medicine Juan Bi Pill METHOTREXATE active rheumatoid arthritis randomized controlled trial

Protective effects of probiotics against methotrexate-induced intestinal toxicity in the mice model: 《BIOCELL》2025年第1期7-20,共14页KSENIA SSTAFEEVA NATALIA ASAMOYLOVA OLGA AKARANDEEVA VERONIKA VNESTEROVA KIRILL ASTARODUBTSEV EVGENY VMIKHAILOV ILYA OKRUTOV EVGENY SPOPOV NATALIA SRODIONOVA ANASTASIA VKOKINA ARTEM PGUREEV; This research was carried out within the State Assignment of the Ministry of Science and Higher Education of the Russian Federation(project FZGW-2024-0003).; Objective:The objective of this study was to determine the level of methotrexate(MTX)toxicity in the intestines of mice and to evaluate the protective effect of probiotics composed of Streptococcus,Bifidobacterium,and...; 关键词：Small intestine Mitochondrial DNA MITOCHONDRIA Il1b Trp53bp1

A biomimetic,triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice: 《BMEMat(BioMedical Engineering Materials)》2024年第4期130-141,共12页He Ren Zewen Wu Jingxuan Li Nan Zhang Coo Yee Nah Jiexin Li Jingyu Zhang Jonathan F.Lovell Liyun Zhang Yumiao Zhang; This work was supported by the National Natural Science Foundation of China(22375144 and 32071384);the National Key Research and Development Program(2021YFC2102300);the basic research project of Shanxi Science and Technology Department(202103021224342);Key Research and Development(R&D)Projects of Shanxi Province(2021XM01).; Rheumatoid arthritis(RA)is a systemic autoimmune disease that leads to the destruction of articular cartilage and bone.RA is characterized by immune cell infiltration and abnormal proliferation of synoviocytes in the ...; 关键词：co-loading MICELLE microenvironment-responsive rheumatoid arthritis self-immolative

Ferroptosis and Intrinsic Drug-induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective: 《Journal of Clinical and Translational Hepatology》2024年第12期1057-1066,共10页Hartmut Jaeschke Anup Ramachandran; supported in part by National Institute of Diabetes and Digestive and Kidney Diseases grants R01 DK102142(HJ)and R01 DK125465(AR),as well as by National Institute of General Medical Sciencesfunded Liver Disease COBRE grants P20 GM103549(HJ)and P30 GM118247(HJ).; Drug-induced hepatotoxicity is a significant clinical issue worldwide.Given the limited treatment options for these liver injuries,understanding the mechanisms and modes of cell death is crucial for identifying novel ...; 关键词：Drug hepatotoxicity ACETAMINOPHEN Lipid peroxidation Oxidative stress Ferroptosis Glutathione peroxidase 4 Erastin Ferrostatin-1 METHOTREXATE RIFAMPICIN ISONIAZID Natural products

Sintilimab (anti-PD-1 antibody) combined with high-dose methotrexate, temozolomide, and rituximab (anti-CD20 antibody) in primary central nervous system lymphoma: a phase 2 study: 《Signal Transduction and Targeted Therapy》2024年第10期4554-4563,共10页Zhiyong Zeng Apeng Yang Jingke Yang Sheng Zhang Zhen Xing Xingfu Wang Wenzhong Mei Changzhen Jiang Junfang Lin Xiyue Wu Yihui Xue Zanyi Wu Lianghong Yu Dengliang Wang Jianwu Chen Shufa Zheng Qiaoxian Lin Qingjiao Chen Jinfeng Dong Xiaoqiang Zheng Jizhen Wang Jinlong Huang Zhenying Chen Ping Chen Meihong Zheng Xiaofang Zhou Youwen He Yuanxiang Lin Junmin Chen; https://doi.org/10.1038/s41392-024-01941-x Fujian Provincial Health Technology Project[grant number 2023CXA028];Joint Funds for the Innovation of Science and Technology,Fujian Province(grant number 2023Y9021);National Science Foundation of Fujian Province[grant number 2022J02036];Clinical research project of Wu Jieping Medical Foundation[grant number 320.6750.19094-41];National Natural Science Foundation of China[grant number 82070218,81400160].; Primary central nervous system lymphoma(PCNSL)is a rare and frequently fatal lymphoma subtype.The programmed death-1(PD-1)pathway has emerged as a potential therapeutic target,but the effectiveness of PD-1 antibody si...; 关键词：METHOTREXATE LYMPHOMA system

Clinical and laboratory features of juvenile idiopathic arthritis with wrist involvement:Results of a retrospective cohort study: 《World Journal of Clinical Pediatrics》2024年第3期22-33,共12页Lyubov Sorokina Maria Kaneva Artem Artamonov Natalia Gordeeva Irina Chikova Mikhail Kostik; Supported by Ministry of Science and Higher Education of the Russian Federation,No.075-15-2022-301.; BACKGROUND Previous studies in the pre-biological era showed an association of wrist inflammation in juvenile idiopathic arthritis(JIA)with progressive disease course,polyarticular involvement and failure of methotrex...; 关键词：WRIST HAND Juvenile idiopathic arthritis OUTCOMES BIOLOGICS METHOTREXATE

FOXM1 mediates methotrexate resistance in osteosarcoma cells by promoting autophagy: 《Acta Biochimica et Biophysica Sinica》2024年第9期1289-1299,共11页Luoyang Wang Dongchang Zhai Lei Tang Hui Zhang Xinlong Wang Ning Ma Xiaoyue Zhang Mingguo Cheng Ruowu Shen; supported by the grant from the Natural Science Foundation of Qingdao,Shandong(No.22-3-7-smjk-7-nsh).; Osteosarcoma(OS)is a primary bone cancer mostly found in adolescents and elderly individuals.The treatment of OS is still largely dependent on traditional chemotherapy.However,the high incidence of drug resistance rem...; 关键词：OSTEOSARCOMA drug resistance FOXM1 METHOTREXATE

A gold-based multiplex immunochromatographic sensor for detecting paclitaxel: 《Nano Research》2024年第7期6420-6429,共10页Xiaoqian Jiang Aihua Qu Xinxin Xu Hua Kuang Liqiang Liu Chuanlai Xu; financially supported by the National Natural Science Foundation of China(Nos.22236002 and 21925402);this work is also financially supported by National Key R&D Program(No.2021YFA1200300).; Paclitaxel(PTX),methotrexate(MTX),and 5-fluorouracil(5-FU)are commonly-used small molecule anti-tumor drugs for breast cancer.Unfortunately,drug resistance occurs with long-term treatment or excessive use,and the high...; 关键词：PACLITAXEL METHOTREXATE 5-FLUOROURACIL immunochromatographic assay PLASMA URINE

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