5-FLUOROURACIL

作品数：301被引量：991H指数：13
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IFNα2b/5-FU inhibits proliferation and cell cycle of squamous carcinoma cell line Cal27
《International Journal of Ophthalmology(English edition)》2025年第4期565-574,共10页Zong-Bo Wu Gong-Yue Wang Bei Wang Xi Peng Jia-Song Wang Ming-Chang Zhang Wen Geng Hua-Tao Xie 
All data and materials are available in the article upon reasonable request to the corresponding author.Foundations:Supported by the National Natural Science Foundation of China(No.82070934;No.82171025).
AIM:To investigate the pathological features of ocular surface squamous neoplasia(OSSN)and evaluate the synergistic therapeutic effects of interferon-α2b(IFNα2b)and 5-fluorouracil(5-FU)on cellular proliferation,migr...
关键词：ocular surface squamous neoplasia squamous carcinoma cells interferon-α2b 5-FLUOROURACIL combination index 
Chitosan oligosaccharide enhances the anti-cancer effects of 5-fluorouracil on SNU-C5 colorectal cancer cells by activating ERK
《Oncology Research》2025年第4期873-884,共12页JI-SU HAN HYE-JIN BOO JIN WON HYUN HEESANG SONG IN-YOUB CHANG SANG-PIL YOON 
supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Korea government(2021R1F1A1063023);by the Ministry of Education(RS-2023-00270936).
Background:Chitosan oligosaccharide(COS)is the major degradation product of chitosan by enzymatic processes.COS,with complete water solubility,exerts significant biological effects,including anti-cancer activity.We in...
关键词：Chitosan oligosaccharide(COS) Colorectal cancer(CRC) 5-Fluorouracil(5-FU) ERK(Extracellular signal-regulated protein kinase) 
Potential effects of adenosine triphosphate and melatonin on oxidative and inflammatory optic nerve damage in rats caused by 5-fluorouracil
《International Journal of Ophthalmology(English edition)》2025年第2期222-228,共7页Ahmet Mehmet Somuncu Busra Parlak Somuncu Ahmet Duhan Ozbay Ibrahim Cicek Bahadir Suleyman Renad Mammadov Seval Bulut Tugba Bal Tastan Taha Abdulkadir Coban Halis Suleyman Aliyev Aydin 
AIM:To investigate the effects of adenosine triphosphate(ATP)and melatonin,which have antioxidant and antiinflammatory activities,on potential 5-fluorouracil(5-FU)-induced optic nerve damage in rats.METHODS:Twenty-fou...
关键词：adenosine triphosphate MELATONIN 5-FLUOROURACIL optic nerve damage ANTIOXIDANT ANTIINFLAMMATORY 
Modified Pulsatilla decoction alleviates 5-fluorouracil-induced intestinal mucositis by modulating the TLR4/MyD88/NF-κB pathway and gut microbiota
《World Journal of Gastroenterology》2025年第7期110-129,共20页Yi-Tong Qiu Xin-Yi Luo Ya-Feng Deng Xue Zheng Jian-Guo Qiu Lin-Sheng Zhang Xiao-Qi Huang Xue-Bao Zheng Hai-Yang Huang 
Supported by Basic and Applied Basic Research Foundation of Guangdong Province,No.2021B1515140043,No.2022A1515140124 and No.2023A1515140115.
BACKGROUND Modified Pulsatilla decoction(PD),a PD with licorice and ejiao,is a classic Traditional Chinese Medicine formula with significant efficacy in treating intestinal mucositis(IM)induced by tumor therapy.Howeve...
关键词：Modified Pulsatilla decoction Intestinal mucositis Oxidative stress Gut microbiota TLR4/MyD88/NF-κB pathway Inflammatory response 
5-氟尿嘧啶长循环脂质体的制备及表征
《锦州医科大学学报》2024年第6期22-30,共9页高玥媛 周浩 张宇 胡海洋 
目的采用复合磷脂制备5-氟尿嘧啶(5-fluorouracil,5-FU)长循环脂质体,进行处方和工艺优化,并建立初步表征评价。方法采用逆向蒸发法制备5-FU复合磷脂长循环脂质体,用聚乙二醇(DSPE-mPEG2000)修饰脂质体,并根据单因素试验考察复合磷脂的...
关键词：5-FLUOROURACIL 复合磷脂 长循环脂质体 正交试验 
HLX07 alone or combined with serplulimab,cisplatin and 5-fluorouracil for advanced esophageal squamous cell carcinoma:A phase 2 study
《Cancer Communications》2024年第12期1431-1443,共13页Yun Liu Yanfeng Wang Yanrong Zhu Tao Wu Zhenyang Liu Jin Zhou Yuan Yuan Mudan Yang Bo Liu Zhenbo Tan Wu Zhuang Jiayan Chen Ning Li Ying Wang Xuhui Hu Lin Wang Haoyu Yu QingyuWang Jun Zhu Jing Huang 
Shanghai Henlius Biotech Inc.
Background:The combination of anti-PD-1 antibody serplulimab and chemotherapy is considered standard first-line therapy for advanced esophageal squamous cell carcinoma(ESCC),but few later-line treatments are available...
关键词：ANTI-EGFR esophageal squamous cell carcinoma HLX07 phase 2 serplulimab 
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer
《Acta Pharmaceutica Sinica B》2024年第12期5321-5340,共20页Rong Fu Zhangfeng Dou Ning Li Xueyuan Fan Sajid Amin Jinqi Zhang Yuqing Wang Zongwei Li Zhuoyu Li Peng Yang 
supported by the National Natural Science Foundation of China(Nos.32200321,82270217,31800657,32072220);National Natural Science Foundation of China Regional Innovation and Development Joint Fund Key Support Project(U23A20526,China);Natural Science Foundation of Shanxi Province(Nos.20210302124252,and 202203021211293,China),Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(2021L212,China);“1331 Project”Key Innovation Team of Shanxi Province(Prof.Zhuoyu Li).
Chemoresistance to 5-fluorouracil(5-FU)is a significant challenge in treating colorectal can-cer(CRC).Novel combined regimens to thwart chemoresistance are therefore urgently needed.Herein,we demonstrated that the com...
关键词：Avenanthramide A 5-FLUOROURACIL KDM4C Colorectal cancer MIR17HG 
Irinotecan hydrochloride liposome HR070803 in combination with 5-fluorouracil and leucovorin in locally advanced or metastatic pancreatic ductal adenocarcinoma following prior gemcitabine-based therapy (PAN-HEROIC-1): a phase 3 trial被引量：1
《Signal Transduction and Targeted Therapy》2024年第10期4628-4636,共9页Jiujie Cui Shukui Qin Yuhong Zhou Shuang Zhang Xiaofeng Sun Mingjun Zhang Jiuwei Cui Weijia Fang Kangsheng Gu Zhihua Li Jufeng Wang Xiaobing Chen Jun Yao Jun Zhou Gang Wang Yuxian Bai Juxiang Xiao Wensheng Qiu Bangmao Wang Tao Xia Chunyue Wang Li Kong Jiajun Yin Tao Zhang Xionghu Shen Deliang Fu Chuntao Gao Huan Wang Quanren Wang Liwei Wang 
Jiangsu Hengrui Pharmaceuticals Co.,Ltd.
Liposomal irinotecan has shown promising antitumor activity in patients with advanced or metastatic pancreatic ductal adenocarcinoma (PDAC) who have undergone prior gemcitabine-based therapies. This randomized, double...
关键词：METASTATIC adenocarcinoma sided 
Clinical outcomes of second-line chemotherapy in patients with advanced pancreatic adenocarcinoma:a real-world study
《Cancer Biology & Medicine》2024年第9期799-812,共14页Yuxiao Liu Xiaofan Guo Peijun Xu Yuning Song Jing Huang Xingyun Chen Wenbo Zhu Jihui Hao Song Gao 
This work was supported by the National Key Research and Development Program of China(Grant No.2021YFA1201100);the National Natural Science Foundation of China(Grant No.82072657).
Objective:Little progress has been made in recent years using first-line chemotherapy,including gemcitabine combined with nab-paclitaxel,FOLFIRINOX,and NALIRIFOX,for advanced pancreatic adenocarcinoma(APC).In addition...
关键词：Second-line chemotherapy advanced pancreatic adenocarcinoma 5-FLUOROURACIL GEMCITABINE real-world study 
Effect of growth hormone on colonic anastomosis after intraperitoneal administration of 5-fluorouracil, bleomycin and cisplatin: An experimental study
《World Journal of Gastrointestinal Surgery》2024年第8期2679-2688,共10页Ioannis Lambrou Ioannis Mantzoros Orestis Ioannidis Dimitrios Tatsis Elissavet Anestiadou Vasiliki Bisbinas Manousos-Georgios Pramateftakis Efstathios Kotidis Barbara Driagka Ourania Kerasidou Savvas Symeonidis Stefanos Bitsianis Freideriki Sifaki Konstantinos Angelopoulos Haralabos Demetriades Stamatios Angelopoulos 
BACKGROUND Growth hormone(GH)plays a crucial role in wound healing and tissue repair in postoperative patients.In particular,colonic anastomosis healing following colorectal surgery is impaired by numerous chemotherap...
关键词：Growth hormone Colonic anastomosis Adhesion Bursting pressure COLLAGEN HYDROXYPROLINE Inflammation NEOANGIOGENESIS Chemotherapy 
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