METASTATIC

作品数：679被引量：1800H指数：17
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相关机构：第二军医大学湖南省肿瘤医院福建医科大学浙江省肿瘤研究所更多>>
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Metastatic pancreatic cancer with activating BRAF V600E mutations:A case report
《World Journal of Clinical Cases》2025年第16期52-59,共8页Fang Li Feng Shen 
Supported by Clinical Research Center for Precision Medicine of Abdominal Tumor of Fujian Province.
BACKGROUND Pancreatic cancer(PC)is a highly malignant tumor that is resistant to chemotherapy,radiotherapy and immunotherapy.Combination chemotherapy regimens are the standard first-line regimens for metastatic diseas...
关键词：Pancreatic cancer BRAF gene mutation Targeted therapy Prognosis Case report 
Understanding metastatic patterns in gastric cancer: Insights from lymph node distribution and pathology
《World Journal of Gastrointestinal Oncology》2025年第4期36-41,共6页Chris B Lamprecht Tyler Kashuv Brandon Lucke-Wold 
Gastric cancer(GC)represents a significant global health burden due to its high morbidity and mortality.Specific behaviors of GC sub-types,distinct dissem-ination patterns,and associated risk-factors remain poorly und...
关键词：Gastric cancer Lymph node metastasis patterns Upper vs lower gastric cancer Prognostic factors Survival outcomes 
The effect of concomitant drugs on oncological outcomes in patients treated with immunotherapy for metastatic urothelial carcinoma:a narrative review
《Oncology Research》2025年第4期741-757,共17页MICHELE MAFFEZZOLI GIULIA CLAIRE GIUDICE GIACOMO IOVANE MARTINA MANINI ELENA RAPACCHI GIUSEPPE CARUSO NICOLA SIMONI STEFANIA FERRETTI STEFANO PULIATTI DAVIDE CAMPOBASSO SEBASTIANO BUTI 
Background:immune checkpoint inhibitors(ICIs)have revolutionized the treatment of metastatic urothelial carcinoma(mUC),significantly improving survival outcomes.However,a subset of patients do not respond to ICIs,prom...
关键词：Immune checkpoint inhibitors(ICIs) Urothelial carcinoma(UC) Concomitant drugs Proton pump inhibitors Antibiotics(Abs) Angiotensinconverting enzyme inhibitors(ACEIs) 
A Nomogram for Predicting Survival for Patients with Brain Metastatic and EGFR Mutation Advanced Non-Small Cell Lung Cancer
《Oncology Research》2025年第4期895-904,共10页JIYUN PANG WEIGANG XIU YUEYUN CHEN WENJING LIAO QIN ZHANG HUASHAN SHI 
supported by Sichuan Province Central Government Guide Local Science and Technology Development Project(No.2023ZYD0169).
Background:Non-small cell lung cancer(NSCLC)is often accompanied by brain metastasis(BM),and the prognosis of patients with BM is poor.This study assesses the prognostic impact of BM in NSCLC patients with epidermal g...
关键词：Brain metastasis(BM) Epidermal growth factor receptor(EGFR) Tyrosine kinase inhibitor(TKI) Tumor microenvironment Non-small cell lung cancer(NSCLC) 
Lymph node metastatic patterns of gastric carcinoma with a combination of adenocarcinoma and neuroendocrine carcinoma components
《World Journal of Gastroenterology》2025年第8期24-37,共14页Kai Zhou Zhong-Wu Li Yan Wu Zhi-Jie Wang Ling-Qian Wang Li-Xin Zhou Ling Jia Ke Ji Xue-Song Yang Ji Zhang Xiao-Jiang Wu An-Qiang Wang Zhao-De Bu 
Supported by the National Key Research and Development Program of China,No.2023YFF1204702;the National Natural Science Foundation of China,No.82173151;Capital’s Funds for Health Improvement and Research,No.CFH 2022-4-1025;Beijing Hospitals Authority Clinical Medicine Development of Special Funding,No.XMLX202119;Science Foundation of Peking University Cancer Hospital,No.PY202329.
BACKGROUND Gastric mixed-adenoneuroendocrine carcinoma(G-MANEC)is a subtype of gastric cancer.Building upon prior research findings,we propose that tumours containing both neuroendocrine carcinoma(NEC)and adenocarcino...
关键词：Gastric mixed-adenoneuroendocrine carcinoma Lymph node metastatic patteren Clinicopathological features Adjuvant chemotherapy regimens Prognosis 
Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma
《World Journal of Clinical Oncology》2025年第2期29-35,共7页Shi-Qiong Zhou Peng Wan Seng Zhang Yuan Ren Hong-Tao Li Qing-Hua Ke 
BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor prognosis.When it metastasizes to the liver,treatment options become particularly limited and challenging.Current treatment opti...
关键词：IMMUNOTHERAPY Programmed cell death 1 inhibitor Sintilimab Chemotherapy METASTATIC Pancreatic ductal adenocarcinoma 
Locoregional treatments of metastatic internal mammary node following neoadjuvant chemotherapy
《Chinese Medical Journal》2025年第3期358-360,共3页Jinhui Zhang Huajie Guan Cailu Song Lingrui Liu Hailin Tang Jin Wang 
National Natural Science Foundation of China(No.82273399);Natural Science Foundation of Guangdong Province(No.2022A1515012229);National Natural Science Foundation of China(No.82372742)
To the Editor:Neoadjuvant chemotherapy(NAC)significantly improves the prognosis for patients with breast cancer with internal mammary lymph node(IMN)involvement,[1]but the locoregional treatment of IMNs including IMN ...
关键词：surgical approaches locoregional treatment breast cancer imn boost irradiation imnb cardiopulmonary side effects metastatic internal mammary node internal mammary lymph node imn involvement surgical dissection 
Getting to a Diagnosis: A Rare Case of TFE3 Translocation Renal Cell Carcinoma in a 22-Year-Old Male
《Case Reports in Clinical Medicine》2025年第2期41-50,共10页Bayler Hinz Jessup Kenyon 
Primary renal cell carcinoma (RCC) with metastasis is common with an estimated 30% of patients with RCC having metastases at the time of diagnosis. Evidence of metastatic RCC without a primary renal tumor is extremely...
关键词：Renal Cell Carcinoma METASTATIC Retroperitoneal Mass TUBERCULOSIS Primary Tumor 
Safety,dosimetry,and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors:From preclinical testing to first-in-human study
《Acta Pharmaceutica Sinica B》2025年第2期707-721,共15页Wei Guo Xuejun Wen Yuhang Chen Tianzhi Zhao Jia Liu Yucen Tao Hao Fu Hongjian Wang Weizhi Xu Yizhen Pang Liang Zhao Jingxiong Huang Pengfei Xu Zhide Guo Weibing Miao Jingjing Zhang Xiaoyuan Chen Haojun Chen 
supported by the National Natural Science Foundation of China(No.82071961);Fujian Research and Training Grants for Young and Middle-aged Leaders in Healthcare,Key Scientific Research Program for Yong Scholars in Fujian(No.2021ZQNZD016,China);Fujian Natural Science Foundation for Distinguished Young Scholars(No.2022D005,China);Innovation of Science and Technology,Fujian Province(No.2021Y9134,China);National University of Singapore(No.NUHSRO/2020/133/Startup/08,NUHSRO/2023/008/NUSMed/TCE/LOA,NUHSRO/2021/034/TRP/09/Nanomedicine);National Medical Research Council(No.MOH-001388-00,MOH-001041,CG21APR1005,Singapore);Singapore Ministry of Education(No.MOE-000387-00,Singapore);National Research Foundation(No.NRF-000352-00,Singapore).
Peptide receptor radionuclide therapy(PRRT)with radiolabeled SSTR2 agonists is a treatment option that is highly effective in controlling metastatic and progressive neuroendocrine tumors(NETs).Previous studies have sh...
关键词：Radiolabeled somatostatin analog Neuroendocrine tumor Evans blue ^(177)Lu-LNC1010 Peptide receptor radionuclide therapy First-in-human dose escalation study 
Reciprocal tumor-platelet interaction through the EPHB1-EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma
《Cancer Communications》2025年第2期143-166,共24页Lin-Li Yao Wei-Ting Qin Li-Peng Hu Tie-Zhu Shi Jian Yu Yang Qing Li Hui-Zhen Nie Jun Li Xu Wang Lei Zhu De-Jun Liu Yan-Li Zhang Shu-Heng Jiang Zhi-Gang Zhang Xiao-Mei Yang Dong-Xue Li Xue-Li Zhang 
Natural Science Foundation of Shanghai,Grant/Award Number:22ZR1460000;Shanghai Municipal Health Commission,Grant/Award Number:202340202;National Natural Science Foundation of China,Grant/Award Numbers:82073023,82103357,82173153,82230087,82273228,82303278,82350123,82372821,92168111;Innovative research team of high-level local universities in Shanghai,Grant/Award Number:SHSMU-ZDCX20210802。
Background:The interaction between the metastatic microenvironment and tumor cells plays an important role in metastatic tumor formation.Platelets play pivotal roles in hematogenous cancer metastasis through tumor cel...
关键词：Liver metastatic niche Tumor-platelet interaction Axon guidance molecule Reverse signaling 5-HT 
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