Understanding metastatic patterns in gastric cancer: Insights from lymph node distribution and pathology  

作　　者：Chris B Lamprecht Tyler Kashuv Brandon Lucke-Wold 

机构地区：[1]Lillian S.Wells Department of Neurosurgery,University of Florida,Gainesville,FL 32608,United States

出　　处：《World Journal of Gastrointestinal Oncology》2025年第4期36-41,共6页世界胃肠肿瘤学杂志(英文)

摘　　要：Gastric cancer(GC)represents a significant global health burden due to its high morbidity and mortality.Specific behaviors of GC sub-types,distinct dissem-ination patterns,and associated risk-factors remain poorly understood.This editorial highlights several key prognostic factors,including pathological staging and vascular invasion,that impact GC.It examines a recent study’s investigation of differential metastatic lymph nodes distribution and survival in upper and lower GC sub-types,focusing on histological characterization,pathophysiology,usage of neoadjuvant chemotherapy,and additional predictive determinants.We assess the statistical robustness and clinical applicability of the findings,un-derscoring the importance of treating GC as a heterogeneous disease and em-phasizing how tailored surgical approaches informed by lymph node distribution can optimize tumor detection while minimizing unnecessary interventions.The study’s large cohort,multi-center design,and strict inclusion criteria strengthen its validity in guiding surgical planning and risk-stratification.However,inte-grating genetic and molecular data is critical for refining models and broadening applicability.Additionally,recurrence-metrics and infection-related factors,such as Helicobacter pylori and Epstein-Barr virus,absent in the original study,remain vital for directing future research.By bridging metastatic patterns with pros-pective methodologies and inclusion of diverse populations,this editorial pro-vides a framework for advancing early detection and personalized GC care.

关 键 词：Gastric cancer Lymph node metastasis patterns Upper vs lower gastric cancer Prognostic factors Survival outcomes 

分 类 号：R73[医药卫生—肿瘤]