MICELLE

作品数：198被引量：307H指数：7
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Insight into the Solution Self-Assembly of Amphiphilic Asymmetric Brush Copolymers via Computer Simulations
《Chinese Journal of Polymer Science》2025年第1期132-140,I0010,共10页Wei-Ting Zeng Wei-Sheng Feng Xing Zhang Yuan Yao Bin-Bin Xu Shao-Liang Lin 
supported by the National Science Foundation for Distinguished Young Scholars(No.52325308);the National Natural Science Foundation of China(Nos.52273008 and 52073092);Shanghai Scientific and Technological Innovation Projects(No.22ZR1479300);Shanghai Rising-Star Program(No.23QA1402500).
Amphiphilic asymmetric brush copolymers(AABCs)possess unique self-assembly behaviors owing to their asymmetric brush architecture and multiple functionalities of multicomponent side chains.However,the synthesis of AAB...
关键词：Dissipative particle dynamics Brush copolymer SELF-ASSEMBLY Channelized micelle 
A biomimetic,triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice
《BMEMat(BioMedical Engineering Materials)》2024年第4期130-141,共12页He Ren Zewen Wu Jingxuan Li Nan Zhang Coo Yee Nah Jiexin Li Jingyu Zhang Jonathan F.Lovell Liyun Zhang Yumiao Zhang 
This work was supported by the National Natural Science Foundation of China(22375144 and 32071384);the National Key Research and Development Program(2021YFC2102300);the basic research project of Shanxi Science and Technology Department(202103021224342);Key Research and Development(R&D)Projects of Shanxi Province(2021XM01).
Rheumatoid arthritis(RA)is a systemic autoimmune disease that leads to the destruction of articular cartilage and bone.RA is characterized by immune cell infiltration and abnormal proliferation of synoviocytes in the ...
关键词：co-loading MICELLE microenvironment-responsive rheumatoid arthritis self-immolative 
Nanoscale“precision strike”:Tumor microenvironment-responsive smart micelles for efficient targeted drug delivery
《Nano Research》2024年第9期8360-8367,共8页Dong Wan Yarong Song Xiujuan Lu Yanfeng Huang Jianxin Zhang Yonghui Liu Yi Liu Jie Pan 
financial support from National Natural Science Foundation of China(Nos.22178270,22078246,82103984,and U23A2089).
To address the limitations of conventional nanotechnology-based drug delivery systems,this work developed enzyme and reduction dual-responsive polymeric micelles.These micelles were synthesized with copolymers compose...
关键词：CANCER PEPTIDE MICELLE dual-responsive folate 
Remote-controlled dexamethasone-duration on eye-surface with a micelle-magnetic nanoparticulate co-delivery system for dry eye disease
《Acta Pharmaceutica Sinica B》2024年第8期3730-3745,共16页Qinxiang Zheng Chaoxiang Ge Kexin Li Longxin Wang Xiaoyu Xia Xiao Liu Rashid Mehmood Jianliang Shen Kaihui Nan Wei Chen Sen Lin 
supported by National Natural Science Foundation of China(No.82070932);the Zhejiang Provincial Natural Science Foundation of China(No.LY19H120002);the internal funding of Wenzhou Medical University(No.KYYW202020,China);The Project of Wenzhou Medical University Affiliated Eye Hospital(No.YNZD2201901,China);the integration project of State Key Laboratory of Ophthalmology,Optometry and Vision Science(No.J02-20190202,China).
Dexamethasone(DEX)is used to treat ocular surface diseases.However,regulating DEX duration in tears while preventing its absorption into the anterior chamber is critical for balancing its therapy effects and the side ...
关键词：Magnetic nanoparticle MICELLE DEXAMETHASONE Eye drop BIOAVAILABILITY Dry eye disease CORNEA CONJUNCTIVA 
Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy
《Chinese Chemical Letters》2024年第7期377-382,共6页Mengjuan Sun Muye Zhou Yifang Xiao Hailei Tang Jinhua Chen Ruitao Zhang Chunjiayu Li Qi Ya Qian Chen Jiasheng Tu Qiyue Wang Chunmeng Sun 
supported by the National Natural Science Foundation of China(Nos.81972894,22278442,82273882)。
Size is one of the most important characteristics of nanoparticles to influence their biodistribution and antitumoral efficacy.Particles with large sizes have difficulty in deep tumor penetration,while small particles...
关键词：Polyion complex micelle Size-switchable Revisable size-change pH response Antiangiogenic cancer 
Advanced nanoparticles in osteoarthritis treatment
《Biomaterials Translational》2024年第2期95-113,共19页Qiushi Liang Zhiliang Cheng Ling Qin 
supported by National Institutes of Health,Nos.R21AR078650,R01AG067698,R01AR079875(to LQ),R01AR080820;Health Research Formula Fund from the Pennsylvania Department of Health(to ZC).
Osteoarthritis(OA)is the most prevalent degenerative joint disorder,affecting hundreds of millions of people globally.Current clinical approaches are confined to providing only symptomatic relief.Research over the pas...
关键词：CARTILAGE LIPOSOME MICELLE NANOPARTICLES OSTEOARTHRITIS SYNOVIUM 
Hydrophobic modification of polysaccharides and the construction and properties of their micelles:a review of applications in the field of biomedicine
《Science China Chemistry》2024年第6期1881-1903,共23页Dayang Wang Xiaohua Li Huanchen Yao Xin Liu Yan Gao Hailin Cong Bing Yu Youqing Shen 
supported by the National Natural Science Foundation of China(21874078,22074072,22274083);the Shandong Provincial Natural Science Foundation(ZR2022LZY022,ZR2023LZY005);the Science and Technology Planing Project of South District of Qingdao City(2022-4-005-YY);the Exploration project of the State Key Laboratory of BioFibers and EcoTextiles of Qingdao University(TSKT202101);the High Level Discipline Project of Shandong Province。
Nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific research.Polysaccharides have the characteristics of wide sources,excellent biocompatibi...
关键词：POLYSACCHARIDE hydrophobic modification MICELLE drug delivery BIOMEDICINE 
Micelle-directed self-assembly of single-crystal-like mesoporous stoichiometric oxides for high-performance lithium storage
《National Science Review》2024年第4期189-199,共11页Yanhua Wan Changyao Wang Xingmiao Zhang Yang Yin Mengmeng Liu Bing Ma Linlin Duan Yuzhu Ma Wei Zhang Changlin Zheng Dongliang Chao Fei Wang Yongyao Xia Wei Li 
This work was supported by the National Key R&D Program of China(2022YFA1503501 and 2022YFA1504103);the National Natural Science Foundation of China(22088101,62171136 and U21A20329);the Program of Shanghai Academic Research Leader(21XD1420800);the Shanghai Pilot Program for Basic Research-Fudan University(21TQ1400100 and 21TQ008);the Shanghai International Science and Technology Partnership Project(23520750400).
Due to their uncontrollable assembly and crystallization process,the synthesis of mesoporous metal oxide single crystals remains a formidable challenge.Herein,we report the synthesis of single-crystal-like mesoporous ...
关键词：mesoporous materials micelles single-crystal-like Li_(2)TiSiO_(5) lithium-ion batteries 
Ultrasensitive detection of TDP-43 and amyloid-βprotein aggregates using micelle-assisted seed amplification assay
《Translational Neurodegeneration》2024年第1期324-328,共5页Sora Sakamoto Yuichi Riku Teiko Komori Nomura Akio Kimura Naoki Yamahara Kazuki Ohuchi Mari Yoshida Yasushi Iwasaki Takayoshi Shimohata Masatoshi Inden Ryo Honda 
supported by grants from SERIKA Foundation(to R.H.),Yukihiko Miyata Memorial Trust for ALS research(to R.H.),JSPS KAKENHI JP23K06935(to Y.R.),JP22K07359(to Y.R.),JP22K06744(to M.I.).
Main text Ultrasensitive detection of pathological protein aggre-gates is crucial for early diagnosis and monitoring of neurodegenerative diseases.The seed amplification assay(SAA),a method involving in vitro amplific...
关键词：UNSTABLE Aβ diagnosis TDP 
In Situ Sustained Macrophage-Targeted Nanomicelle-Hydrogel Microspheres for Inhibiting Osteoarthritis被引量：1
《Research》2024年第1期1-16,共16页XiaoXiao Li Xingchen Li Jielai Yang Yawei Du Liang Chen Gang Zhao Tingjun Ye Yuan Zhu Xiangyang Xu Lianfu Deng Wenguo Cui 
funded by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52103174,52273133,and 82202686);the Shanghai Pujiang Program(2021PJD044);the Shanghai Municipal Heaith and Family Planning Commission(2022XD055);the China Postdoctoral Science Foundation(2022T150420 and 2022M712100);the Shanghai Jiading District Health Committee(2022-QN-05);the GuangCi Professorship Program of Ruijin Hospital Shanghai Jiao Tong University School of Medicine.
There are stillchallenges in applying drug nanocarriers for in situ sustained macrophage targeting and regulation,due to the rapid clearance of nanocarriers and burst drug release invivo.Herein,a nanomicellehydrogel m...
关键词：MICELLE release SPHERES 
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