In Situ Sustained Macrophage-Targeted Nanomicelle-Hydrogel Microspheres for Inhibiting Osteoarthritis  

作　　者：XiaoXiao Li Xingchen Li Jielai Yang Yawei Du Liang Chen Gang Zhao Tingjun Ye Yuan Zhu Xiangyang Xu Lianfu Deng Wenguo Cui 

机构地区：[1]Department of Orthopaedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopaedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,P.R.China

出　　处：《Research》2024年第1期1-16,共16页研究（英文）

基　　金：funded by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52103174,52273133,and 82202686);the Shanghai Pujiang Program(2021PJD044);the Shanghai Municipal Heaith and Family Planning Commission(2022XD055);the China Postdoctoral Science Foundation(2022T150420 and 2022M712100);the Shanghai Jiading District Health Committee(2022-QN-05);the GuangCi Professorship Program of Ruijin Hospital Shanghai Jiao Tong University School of Medicine.

摘　　要：There are stillchallenges in applying drug nanocarriers for in situ sustained macrophage targeting and regulation,due to the rapid clearance of nanocarriers and burst drug release invivo.Herein,a nanomicellehydrogel microsphere,characterized by its macrophage-targeted nanosized secondary structure that allows it to accurately bind to M1 macrophages through active endocytosis,is employed for in situ sustained macrophage targeting and regulation,and addresses the insufficient osteoarthritis therapeutic efficacy caused by rapid clearance of drug nanocarriers.The 3-dimensional structure of a microsphere can prevent the rapid escape and clearance of a nanomicelle,thus keeping it in joints,while the ligand-guided secondary structure can carry drugs to accurately target and enter M1 macrophages,and release drugs via the transition from hydrophobicity to hydrophilicity of nanomicelles under inflammatory stimulation inside the macrophages.

关 键 词：MICELLE release SPHERES 

分 类 号：O61[理学—无机化学]