LIPOSOME

作品数：275被引量：574H指数：11
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相关领域：医药卫生更多>>
相关作者：范晓婧甄鹏胡新徐毅黄春兰更多>>
相关机构：北京大学中国药科大学上海交通大学成都市第五人民医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家教育部博士点基金更多>>
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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease
《Neural Regeneration Research》2025年第9期2538-2555,共18页Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren 
supported by Open Project of the Key Laboratory of Trauma and Orthopedics Research Medicine in Henan Province,No.HZKFKT20220504(to YZ);the National Natural Science Foundation of China,No.32000877(to YZ);and Open Scientific Research Program of Military Logistics,No.BLB20J009(to YZ)。
Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive defi...
关键词：blood-brain barrier cognitive dysfunction EXOSOMES gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles NEUROINFLAMMATION polymer nanoparticles stem cells 
Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety
《Neural Regeneration Research》2025年第7期1883-1899,共17页Mingyu Zhang Chunyu Xiang Renrui Niu Xiaodong He Wenqi Luo Wanguo Liu Rui Gu 
supported by the National Natural Science Foundation of China, Nos. 82271411 (to RG), 51803072 (to WLiu);grants from the Department of Finance of Jilin Province, Nos. 2022SCZ25 (to RG), 2022SCZ10 (to WLiu), 2021SCZ07 (to RG);Jilin Provincial Science and Technology Program, No. YDZJ202201ZYTS038 (to WLiu);The Youth Support Programmed Project of China-Japan Union Hospital of Jilin University, No. 2022qnpy11 (to WLuo);The Project of China-Japan Union Hospital of Jilin University, No. XHQMX20233 (to RG)
Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely studied.However,their inability to cross the blood–brain barrier hampers the clinical translation of these...
关键词：Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury 
A dual drug-loaded tumor vasculature-targeting liposome for tumor vasculature disruption and hypoxia-enhanced chemotherapy
《Chinese Chemical Letters》2025年第1期397-402,共6页Cheng-Zhe Gao Hao-Ran Jia Tian-Yu Wang Xiao-Yu Zhu Xiaofeng Han Fu-Gen Wu 
supported by the Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University),Ministry of Education(No.GKE-KF202305);the Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor,and the Natural Science Foundation of Jiangsu Province(No.BK20211510)。
Vascular disrupting agents(VDAs)can destroy tumor vasculature and lead to tumor ischemia and hypoxia,resulting in tumor necrosis.However,VDAs are easy to induce the upregulation of genes that are associated with cance...
关键词：Tumor-homing peptide LIPOSOME Vascular disrupting agents CHEMOTHERAPY Hypoxia-activated 
Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome:Focusing on inflammation and molecular mechanisms
《Animal Models and Experimental Medicine》2025年第1期5-19,共15页Mohammad Yasin Zamanian Hamidreza Zafari Maria K.Osminina Alla A.Skakodub Raed Fanoukh Aboqader Al-Aouadi Maryam Golmohammadi Nikta Nikbakht Iman Fatemi 
Rheumatoid arthritis(RA)is a chronic autoimmune disease that affects approxi-mately 0.46%of the global population.Conventional therapeutics for RA,including disease-modifying antirheumatic drugs(DMARDs),nonsteroidal a...
关键词：DEXAMETHASONE INFLAMMATION LIPOSOME rheumatoid arthritis TNF-α 
Near-Infrared Light-Responsive Cubic Vesicles for Enhanced Blood-Brain Barrier Permeability and Drug Delivery
《Journal of Clinical and Nursing Research》2024年第12期223-233,共11页Xinyu Wang Xiaorong Zheng Junfei Li Changming Shen Hongyan Zhang Jianwei Jiang 
the Zhejiang Provincial Natural Science Foundation of China for supporting this project;funded by the Joint Funds of the Zhejiang Provincial Natural Science Foundation of China,awarded to Jianwei Jiang(No.LBQ20H300001).
Delivering therapeutic agents to the central nervous system(CNS)is challenging due to the blood-brain barrier(BBB).This study presents a novel approach utilizing near-infrared(NIR)light-responsive gold-coated cubic ve...
关键词：Controlled drug release Blood-brain barrier LIPOSOME Gold nanoparticles Drug delivery 
Liposome-based RNAi delivery in honeybee for inhibiting parasite Nosema ceranae被引量：1
《Synthetic and Systems Biotechnology》2024年第4期853-860,共8页Yue Qi Chen Wang Haoyu Lang Yueyi Wang Xiaofei Wang Hao Zheng Yuan Lu 
supported by the National Natural Science Foundation of China(32170495,22278241);the National Key R&D Program of China(2018YFA0901700);a grant from the Institute Guo Qiang,Tsinghua University(2021GQG1016);the Department of Chemical Engineering-iBHE Joint Cooperation Fund.
Nosema ceranae,a parasite that parasitizes and reproduces in the gut of honeybees,has become a serious threat to the global apiculture industry.RNA interference(RNAi)technology can be used to inhibit N.ceranae growth ...
关键词：HONEYBEE LIPOSOME Nosema ceranae RNA interference 
Dual alarmin-receptor-specific targeting peptide systems for treatment of sepsis
《Acta Pharmaceutica Sinica B》2024年第12期5451-5463,共13页Seok-Jun Mun Euni Cho Woo Jin Gil Seong Jae Kimc Hyo Keun Kim Yu Seong Ham Chul-Su Yang 
supported by a National Research Foundation of Korea grant funded by the Korean government(MSIP)(grant Nos.2019R1I1A2A01064237 and 2021R1A4A5032463 to Chul-Su Yang);a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI)funded by the Ministry of Health&Welfare,Republic of Korea(HI22C0884 to Chul-Su Yang).
The pathophysiology of sepsis is characterized by a systemic inflammatory response to infec-tion;however,the cytokine blockade that targets a specific early inflammatory mediator,such as tumor necrosis factor,has show...
关键词：SEPSIS High mobility group box 1 Pentraxin 3 LIPOSOME ANTIBIOTICS 
Facile and versatile PDMS-glass capillary double emulsion formation device coupled with rapid purification toward microfluidic giant liposome generation
《Microsystems & Nanoengineering》2024年第6期473-483,共11页Mostafa Bakouei Ali Kalantarifard Indraja Sundara Raju Tatiana Avsievich Lauri Rannaste Marjut Kreivi Caglar Elbuken 
supported by the Academy of Finland,NanoEngineered Self-Assembling Vesicle Production Line(NESAV)project,grant no.342448;The University of Oulu&The Research Council of Finland,Profi 5,Decision no.326291 and VTT-Technical research center of Finland Ltd,iBEX Innovation Program(ArtOfCell 2021 project).
The exceptional ability of liposomes to mimic a cellular lipid membrane makes them invaluable tools in biomembrane studies and bottom-up synthetic biology.Microfluidics provides a promising toolkit for creating giant ...
关键词：VERSATILE CAPILLARY EMULSION 
Construction of degradable liposome-templated microporous metal-organic frameworks with commodious space for enzymes
《Chinese Chemical Letters》2024年第11期294-298,共5页Cheng Cheng Nasir Ali Ji Liu Juan Qiao Ming Wang Li Qi 
the financial support from the National Natural Science Foundation of China(No.22274159)。
The construction of enzyme reactors based on metal-organic frameworks(MOFs)as the immobilized matrix is a proven strategy that has achieved the widespread application of enzymes across industries.Although many MOFs an...
关键词：Metal organic frameworks Degradable liposomes Enzyme conformational freedom NANOREACTOR BIOCATALYSIS 
Encapsulating taurine into liposomes:A promising therapeutic for liver fibrosis
《World Journal of Gastroenterology》2024年第41期4509-4513,共5页Xue-Juan Zhang Xiao-Yi Jiang Yi-Lin Ma Fei-Yi Huang Zheng-Wei Huang 
Supported by the National Natural Science Foundation of China,No.82373800;Guangdong Basic and Applied Basic Research Foundation,No.2024A1515011236;General Program of Administration of Traditional Chinese Medicine of Guangdong Province,No.20241071.
We summarize the mechanism by which taurine(Tau)inhibits autophagy and induces iron apoptosis in hepatic stellate cells.Tau interacts with autophagy regulates multifunctional proteins,microtubule-associated protein 1 ...
关键词：Taurin LIPOSOME Liver fibrosis Targeted therapy Nanoparticle delivery systems Hepatic stellate cells 
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