GLIOBLASTOMA

作品数：391被引量：880H指数：14
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相关作者：王占祥张良张继陈四方谭国伟更多>>
相关机构：中山大学厦门大学首都医科大学附属北京天坛医院复旦大学更多>>
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HMGN2 accelerates the proliferation and cell cycle progression of glioblastoma by regulating CDC20 expression
《Genes & Diseases》2025年第3期492-507,共16页Jiacheng Zhong Shuang Shi Wen Peng Hongjuan Cui Xiaochuan Sun 
Gliomas represent the most common primary malignant intracranial tumors in adults.Despite recent advances in treatment,the prognosis of patients with glioblastoma remains poor.Epigenetic abnormalities,the hallmarks of...
关键词：CDC20 Epigenetic regulation GLIOMA Histone acetylation HMGN2 
The alternatively spliced diacylglycerol kinase gamma-Δexon13 transcript generated under hypoxia promotes glioblastoma progression
《Oncology Research》2025年第5期1189-1198,共10页MING YANG LIANGZHAO CHU SHUKAI LIN HAN PENG NIYA LONG KAYA XU HUA YANG FENG HAN JIAN LIU 
funded by Guizhou Province Science and Technology Plan Project Qiankehe Foundation-ZK[2023]General 360,362;Science and Technology Fund project of Guizhou Provincial Health Commission(gzwkj-2022-09,gzwkj-2023-035);National Natural Science Foundation Cultivation Project of Guizhou Medical University(21NSFCP14,gyfynsfc-2022-25);The PhD Scientific Research Launch Fund Project of the Affiliated Hospital of Guizhou Medical University(gyfybsky-2022-02).
Background:Glioblastoma(GBM)is one of the most malignant types of central nervous system tumors.Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression.Howeve...
关键词：Glioblastoma(GBM) HYPOXIA Diacylglycerol kinase gamma(DGKG) Alternative splicing 
Blocked bioorthogonal chemistry enabled switchable bioorthosome to improve liposomal drug delivery for glioblastoma therapy
《Nano Research》2025年第4期388-401,共14页Chao Wang Jie Wu Zhiran Duan Yuqing Pan Haijing Qu Wei Cheng Ning Wang Han Chen Xiaoli Gao Mengqing Hou Ying Zhang Xiangdong Xue 
the National Natural Science Foundation of China(Nos.82172084,81803002,and 32371342);STI2030-Major Projects(No.2022ZD0212500);Shanghai Frontiers Science Center of Drug Target Identification and Delivery(No.ZXWH2170101);Shaanxi Provincial Education Department serves local industrialization projects(No.20JC035);Xi'an Science and Technology Bureau of Shaanxi province-scientific and technological personnel service enterprise project(No.22GXFW0133);Shaanxi innovation team project(No.2023-CXTD-58).
Glioblastoma(GBM)interventions necessitate exceptional precision due to the presence of blood-brain barrier(BBB)and its intricate co-growth with neuron and glial cells.Here,we developed a blocked bioorthogonal chemist...
关键词：GLIOBLASTOMA bioorthogonal chemistry blood-brain barrier LIPOSOME TUMOR-TARGETING 
Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment
《Neural Regeneration Research》2025年第4期1135-1152,共18页Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li Weiwei Lin Zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen 
supported by Project of the Health Shanghai Initiative Special Fund(Medical-Sports Integration,Creating a New Model of Exercise for Health),No.JKSHZX-2022-02(to SC).
Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiqu...
关键词：exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise 
Microglia and brain macrophages are differentially associated with tumor necrosis in glioblastoma:A link to tumor progression
《Oncology Research》2025年第4期937-950,共14页CHRISTINA LOH YUQI ZHENG ISLAM ALZOUBI KIMBERLEY L.ALEXANDER MAGGIE LEE WEI-DONG CAI YANG SONG KERRIE MCDONALD ANNA K.NOWAK RICHARD B.BANATI MANUEL B.GRAEBER 
funding but aspects of this work(computer analysis)were supported by an Australian Research Council(ARC)grant,DP150104472(MBG);The Australian Genomics and Outcomes of Glioma project was funded by a Cancer Council NSW Strategic Research Partnership Grant.
Background:Microglia and brain macrophages contribute significantly to the tumor microenvironment in highly malignant glioblastoma where they are considered important drivers of tumor progression.A better understandin...
关键词：Bone marrow-derived macrophages(BMDM) CD163 Glioblastoma/glioma stem cells(GSCs) IBA1 MICROGLIA Multimodal whole slide analysis Tumor microenvironment 
Assessing the impact of CD73 inhibition on overcoming anti-EGFR resistance in glioma cells
《Oncology Research》2025年第4期951-964,共14页LUIZ FERNANDO LOPES SILVA JULIETE NATHALI SCHOLL AUGUSTO FERREIRA WEBER CAMILA KEHL DIAS PAULINE RAFAELA PIZZATO VINÍCIUS PIERDONÁLIMA JEAN SÉVIGNY ANA MARIA OLIVEIRA BATTASTINI FABRÍCIO FIGUEIRÓ 
supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq,n°406035/2021-0 and PQ n°311580/2021-1,FigueiróF);Instituto Nacional de Ciência e Tecnologia-INCT/CNPq/CAPES/FAPERGS Grant no.465671/2014-4;Jean Sévigny received support from the Natural Sciences and Engineering Research Council of Canada(NSERC,RGPIN-2023-05498).
Objectives:Glioblastoma(GB)is a grade IV glial tumor characterized by high malignancy and dismal prognosis,primarily due to high recurrence rates and therapeutic resistance.The epidermal growth factor receptor(EGFR),a...
关键词：Glioblastoma(GB) Epidermal growth factor receptor(EGFR) CD73 CHEMORESISTANCE TYRPHOSTIN 
FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation
《Science China(Life Sciences)》2025年第3期673-688,共16页Dake Xiao Haowen Ran Lishu Chen Yuanyuan Li Yan Cai Songyang Zhang Qinghui Qi Huiran Wu Cheng Zhang Shuailiang Cao Lanjuan Mi Haohao Huang Ji Qi Qiuying Han Haiqing Tu Huiyan Li Tao Zhou Fangye Li Ailing Li Jianghong Man 
supported by the National Key Research and Development Program of China(2022YFA1303000,2017YFA0505602);the National Natural Science Foundation of China(81872408,81872153).
The infiltration of glioblastoma multiforme(GBM)is predominantly characterized by diffuse spread,contributing significantly to therapy resistance and recurrence of GBM.In this study,we reveal that microtubule deacetyl...
关键词：glioblastoma multiforme(GBM) microtubule deacetylation invasion FSD1 HDAC6 
Ketogenic diet with oxyresveratrol and zinc inhibits glioblastoma and restores memory function and motor coordination
《Oncology Research》2025年第2期381-395,共15页TANVI VIJAY GUJARAN VIGNESH BALAJI EASWARAN RUNALI SANKHE PUGAZHANDHI BAKTHAVATCHALAM HERMAN SUNIL DSOUZA K.SREEDHARA RANGANATH PAI 
Background:To date,there is no effective cure for the highly malignant brain tumor glioblastoma(GBM).GBM is the most common,aggressive central nervous system tumor(CNS).It commonly originates in glial cells such as mi...
关键词：Glioblastoma(GBM) Ketogenic diet(KD) OXYRESVERATROL ZINC Warburg effect 
Surfing the nano-wave:Emerging trends in cancer diagnostics and therapy
《Nano Research》2025年第1期520-544,共25页Genping Fu Yuting Weng Yunfan Li Carl Ho Yiyu Fu Wenxuan Wang Songbin Fu Wenjing Sun Jie Lin Xiaoyu Fan Binbin Jia Mengdi Cai Linlin Li 
supported by the Open Project of the Key Laboratory of Genetic Resources Protection and Disease Prevention and Control of the Ministry of Education of China(No.LPHGRDC2020-002);the Major Marshal List Project of Harbin Medical University(No.HMUMIF-21007);the National Natural Science Foundation of China(No.22305051);the member of Youth Innovation Promotion Association Foundation of CAS,China(No.2023310).
Facing the growing global challenge posed by cancer,the quest for more accurate and potent cancer diagnostic and therapeutic strategies continues to require a multidisciplinary integration approach.This review firstly...
关键词：nanoparticles drug delivery gastric cancer GLIOMA GLIOBLASTOMA 
Inside help for brain tumors: macrophage-mediated myelin recycling promotes cell state-specific glioblastoma progression
《Signal Transduction and Targeted Therapy》2025年第1期1-2,共2页Antonio C.Pagano Zottola Thomas Daubon Varun Venkataramani 
In a recent paper published in Cell, Kloosterman et al. uncovered how lipid-laden macrophages in brain tumor called glioblastomas engage in myelin recycling, demonstrating that these cells process myelin debris into l...
关键词：MYELIN CD36 GLIOBLASTOMA 
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