HYPOXIA

作品数：914被引量：2841H指数：22
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相关领域：医药卫生更多>>
相关作者：颜宏利王思斯薛赓胡新央朱大岭更多>>
相关机构：第二军医大学哈尔滨医科大学浙江大学医学院附属第二医院浙江大学更多>>
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Acquired sensorineural hearing loss,oxidative stress,and microRNAs
《Neural Regeneration Research》2025年第9期2513-2519,共7页Desmond A.Nunez Ru C.Guo 
Hearing loss is the third leading cause of human disability.Age-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health burden.Noise-induced,ototox...
关键词：hearing loss HYPOXIA MICRORNAS oxidative stress SENSORINEURAL 
Hypoxia-triggered photothermal/drug combination therapy of tumors using a perylene diimide molecular capsule
《Science China Chemistry》2025年第3期1009-1017,共9页Fei Yang Guo Wang Kecheng Huang Yanqing Xu Xiao Feng Weizhi Wang Wei Wei 
supported by the National Natural Science Foundation of China (22171021 and 22322403);the Beijing Natural Science Foundation (2232027 and 2242004);the China Postdoctoral Science Foundation (2023M730245)。
Hypoxia is a common characteristic of tumors and associated with poor outcome in most cancer types,thus hypoxia-triggered combined therapeutic systems with well-defined structure hold significant promise for achieving...
关键词：hypoxia-responsive photothermal agent CYCLOPHANES host-guest system NEAR-INFRARED combination therapy 
High-altitude effect on corneal endothelial cells and prognosis in patients with cataract surgeries:a propensity score matched analysis
《International Journal of Ophthalmology(English edition)》2025年第3期409-414,共6页Li-Li Zhu Bing-Xue Zhu Yue Han Yong-Yan Tang Ying-Ying Wen Xu-Hong Zhang Li-Yue Zhang Ri-Lei Zhu Dong-Yu Guo 
AIM:To compare analysis of the impact of high altitude on corneal endothelial cells,and the prognosis in patients with cataract surgeries.METHODS:Totally 265 plateau patients with cataract surgeries performed between ...
关键词：cataract surgery corneal endothelial cells HYPOXIA PLATEAU propensity score matching 
The crosstalk between cellular survival pressures and N6-methyladenosine modification in hepatocellular carcinoma
《Hepatobiliary & Pancreatic Diseases International》2025年第1期67-75,共9页Chu-Li Fu Zheng-Wei Zhao Qiang-Nu Zhang 
supported by grants from Research Founda-tion of Guangzhou Women and Children’s Medical Center for Clinical Doctor (1600110);Science and Technology Projects in Guangzhou (202201011371);Guangzhou Municipalcience and Tech-nology Bureau Foundation (2023A03J0917);Guangdong Basic and Applied Basic Research Foundation (2023A1515220076 and 2022A1515110283)。
Background:Within the tumor microenvironment,survival pressures are prevalent with potent drivers of tumor progression,angiogenesis,and therapeutic resistance.N6-methyladenosine(m6 A)methylation has been recognized as...
关键词：Hepatocellular carcinoma N6-methyladenosine methylation HYPOXIA Target therapy Survival pressure 
AvERF73 positively regulates waterlogging tolerance in kiwifruit by participating in hypoxia response and mevalonate pathway
《Horticultural Plant Journal》2025年第1期162-174,共13页Danfeng Bai Yunpeng Zhong Shichao Gu Xiujuan Qi Leiming Sun Miaomiao Lin Ran Wang Yukuo Li Chungen Hu Jinbao Fang 
funded by the National Key Research and Development Program(Grant No.2022YFD1600700);Major Science and Technology Projects of Henan Province(Grant No.221100110400);the China Agriculture Research System of MOF and MARA(Grant No.CARS-26);Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Science(Grant No.CAAS-ASTIP-2023-ZFRI-03);Yunnan Science and Technology Program(Grant No.202205AF150043);Sichuan Science and Technology Program(Grant No.2021YFN0060)。
Waterlogging stress is one of the greatest environmental threats to kiwifruit growth and development.ERF-VII proteins have been demonstrated to play pivotal roles in regulating plant tolerance to waterlogging.Neverthe...
关键词：ACTINIDIA ERF-VII Waterlogging stress RNA-SEQ DAP-seq 
Fighting hypoxia to improve photodynamic therapy-driven immunotherapy:Alleviating,exploiting and disregarding
《Chinese Chemical Letters》2025年第2期29-40,共12页Liangliang Jia Ye Hong Xinyu He Ying Zhou Liujiao Ren Hongjun Du Bin Zhao Bin Qin Zhe Yang Di Gao 
supported by the Qin Chuangyuan Traditional Chinese Medicine(TCM)and Innovation Research and Development Project of Shaanxi Provincial Administration of TCM(No.2022-QCYZH-017);Natural Science Foundation of Zhejiang Province(No.LY24E030010);Natural Science Foundation of Shaanxi Province(Nos.2022JM183,2024JC-YBMS-272);the Shaanxi Fundamental Science Research Project for Chemistry&Biology(No.22JHQ072);Shaanxi Provincial Key R&D Program(No.2022SF-342HZ);the Fundamental Research Funds for the Central Universities(Nos.xzy012022037,xzy012023002);the Postdoctoral Science Foundation of Shaanxi Province(No.2023BSHYDZZ05);Foundation by Shaanxi Provincial Administration of TCM(No.2021-ZZ-JC032)。
Innovative anti-cancer therapies that activate the immune system show promise in combating cancers resistant to conventional treatments.Photodynamic therapy(PDT)is one such treatment,which not only directly eliminates...
关键词：Photodynamic therapy Tumor hypoxia IMMUNOTHERAPY Immunogenic cell death PHOTOSENSITIZERS NANOMEDICINE 
Curcumin attenuates ochratoxin A and hypoxia co‑induced liver injury in grass carp(Ctenopharyngodon idella)by dual targeting endoplasmic reticulum stress and apoptosis via reducing ROS content
《Journal of Animal Science and Biotechnology》2025年第1期408-423,共16页Liangqin Wu Piao Zhao Pei Wu Weidan Jiang Yang Liu Hongmei Ren Xiaowan Jin Xiaoqiu Zhou Lin Feng 
This research was financially supported by the earmarked fund for CARS(CARS-45);National Natural Science Foundation of China(32273144,32072985);National Key R&D Program of China(2019YFD0900200).
Background Ochratoxin A(OTA)is a toxin widely found in aquafeed ingredients,and hypoxia is a common prob-lem in fish farming.In practice,aquatic animals tend to be more sensitive to hypoxia while feeds are contaminate...
关键词：APOPTOSIS CURCUMIN Endoplasmic reticulum stress Grass carp HYPOXIA Ochratoxin A Oxidative damage 
An Intelligent Triple Assisted Gold Cluster-Based Nanosystem for Enhanced Tumor Photodynamic Therapy
《Chinese Journal of Chemistry》2025年第2期175-183,共9页Fangli Gao Yanru Liu Liang Zhu Jie Zhang Yi Chang Weihua Gao Guanglei Ma Xiaoming Ma Yuming Guo 
financially supported by the National Natural Science Foundation of China(21771058 and 21877027);the Natural Science Foundation of Henan Province(242300421205,212300410009,and 232300421302);the 111 Project(D17007),the Program for Science&Technology Innovation Talents in Universities of Henan Province(23HASTIT002);the Foundation of Henan Educational Committee(23A150021).
Photodynamic therapy (PDT) has been attracted a surge of research interest. However, there are several obstacles to limit the efficacy of PDT, such as hypoxic tumor microenvironment (TME), overexpressed glutathione (G...
关键词：Gold nanoclusters Diselenide-bridged mesoporous silica nanoparticles HYPOXIA Photodynamic therapy CATALASE GSH consuming Mitochondrial targeting Tumor therapy Bioinorganic chemistry Cancer treatment Drug nanocarrier 
Photothermal probiotics delivery of photodynamic agents for enhanced immunogenic cell death within hypoxia center of solid tumors
《Nano Research》2025年第1期642-652,共11页Wen Luo Shiyu Du Yateng Jiang Bangshun He Jun Tang Jingjing Yang Yujun Song 
supported by the National Key R&D Program of China(No.2019YFA0709200);the National Natural Science Foundation of China(Nos.22477056 and 82472379);the Fundamental Research Funds for Central Universities,the Natural Science Foundation of Jiangsu Province(No.BK20200336);the Key Research and Development Program of Jiangsu Province(No.BE2021373);the Program for Innovative Talents and Entrepreneur in Jiangsu,and the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCV20_0036).
Resulting from harsh hypoxic environmental conditions,central cells in the core of solid tumors are usually more aggressive and malignant with a less stable genome.Therefore,therapeutic agents with improved penetratio...
关键词：BACTERIA phototherapies IMMUNOTHERAPY hypoxia targeting tumor penetration 
A dual drug-loaded tumor vasculature-targeting liposome for tumor vasculature disruption and hypoxia-enhanced chemotherapy
《Chinese Chemical Letters》2025年第1期397-402,共6页Cheng-Zhe Gao Hao-Ran Jia Tian-Yu Wang Xiao-Yu Zhu Xiaofeng Han Fu-Gen Wu 
supported by the Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University),Ministry of Education(No.GKE-KF202305);the Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor,and the Natural Science Foundation of Jiangsu Province(No.BK20211510)。
Vascular disrupting agents(VDAs)can destroy tumor vasculature and lead to tumor ischemia and hypoxia,resulting in tumor necrosis.However,VDAs are easy to induce the upregulation of genes that are associated with cance...
关键词：Tumor-homing peptide LIPOSOME Vascular disrupting agents CHEMOTHERAPY Hypoxia-activated 
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