HYPOXIA

作品数：925被引量：2863H指数：22
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相关机构：第二军医大学哈尔滨医科大学浙江大学医学院附属第二医院浙江大学更多>>
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Acquired sensorineural hearing loss,oxidative stress,and microRNAs
《Neural Regeneration Research》2025年第9期2513-2519,共7页Desmond A.Nunez Ru C.Guo 
Hearing loss is the third leading cause of human disability.Age-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health burden.Noise-induced,ototox...
关键词：hearing loss HYPOXIA MICRORNAS oxidative stress SENSORINEURAL 
Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment
《Nano-Micro Letters》2025年第7期126-159,共34页Mengyao Yang Xin Wang Mengke Peng Fei Wang Senlin Hou Ruirui Xing Aibing Chen 
supported by the National Natural Science Foundation of China(Nos.U23A20573,U23A20140,22072154,and 22377127);Hebei Natural Science Foundation(B2024208046 and H2022423314);Huang jin tai plan project of Hebei provincial department of education(HJZD202512);S&T Program of Hebei,the Youth innovation Promotion Association of Chinese Academy of Sciences(No.2021048);the Beijing Nova Program(No.20230484352).
Sonodynamic therapy(SDT)as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound(US),which can safely penetrate the tissue without significant attenuation.SDT not on...
关键词：Sonodynamic therapy Nanosonosensitizers Tumor accumulation Surmounting the hypoxia Orthotopic tumor 
The alternatively spliced diacylglycerol kinase gamma-Δexon13 transcript generated under hypoxia promotes glioblastoma progression
《Oncology Research》2025年第5期1189-1198,共10页MING YANG LIANGZHAO CHU SHUKAI LIN HAN PENG NIYA LONG KAYA XU HUA YANG FENG HAN JIAN LIU 
funded by Guizhou Province Science and Technology Plan Project Qiankehe Foundation-ZK[2023]General 360,362;Science and Technology Fund project of Guizhou Provincial Health Commission(gzwkj-2022-09,gzwkj-2023-035);National Natural Science Foundation Cultivation Project of Guizhou Medical University(21NSFCP14,gyfynsfc-2022-25);The PhD Scientific Research Launch Fund Project of the Affiliated Hospital of Guizhou Medical University(gyfybsky-2022-02).
Background:Glioblastoma(GBM)is one of the most malignant types of central nervous system tumors.Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression.Howeve...
关键词：Glioblastoma(GBM) HYPOXIA Diacylglycerol kinase gamma(DGKG) Alternative splicing 
Exosomal miR-137-3p targets UBE3C to activate STAT3,promoting migration and differentiation into endometrial epithelial cell of human umbilical cord mesenchymal stem cells under hypoxia
《World Journal of Stem Cells》2025年第4期48-63,共16页Wan-Yu Zhang Si-Miao Liu Han-Bi Wang Cheng-Yan Deng 
Supported by the National High Level Hospital Clinical Research Funding,No.2022-PUMCH-B-080 and No.2022-PUMCH-C-064.
BACKGROUND Thin endometrium,leading cause of recurrent implantation failure and infertility,has been found to respond to exosomes.AIM To investigate the efficacy of exosomes in addressing the issue of thin endometrium...
关键词：Endometrial epithelial cells EXOSOMES miR-137-3p Ubiquitin protein ligase E3C Signal transducer and activator of transcription 3 Human umbilical cord mesenchymal stem cells 
Embryonic developmental toxicity in marine medaka(Oryzias melastigma)caused by combined 17α-ethinylestradiol and hypoxic exposure
《Frontiers of Environmental Science & Engineering》2025年第4期47-60,共14页Xian Qin Jiezhang Mo Huiju Lin Runnan Lyu Rudolf Shiu Sun Wu Richard Yuen Chong Kong Keng Po Lai 
supported by a grant from the General Research Fund(CityU 11102918)of the Research Grants Council of Hong Kong SAR of China.
Hypoxia is one of the most pressing global challenges affecting aquatic ecosystems and is primarily driven by global warming and eutrophication.17α-ethinylestradiol(EE2),a representative endocrine-disrupting chemical...
关键词：17α-ethinylestradiol HYPOXIA Embryonic development Locomotion Endocrine disrupting chemicals 
Inhibition of HIF-prolyl hydroxylase promotes renal tubule regeneration via the reprogramming of renal proximal tubular cells
《Acta Pharmacologica Sinica》2025年第4期1002-1015,共14页Jing Li Li-ting Chen You-liang Wang Mei-xia Kang Shi-ting Liang Xi-zhen Hong Fan Fan Hou Fu-jian Zhang 
supported by the National Natural Science Foundation of China(82470812 to FJZ);Guangdong Basic and Applied Basic Research Foundation(2024A1515012857 to FJZ);the National Natural Science Foundation of China(Key Program)(82030022 to FFH);the Program of Introducing Talents of Discipline to Universities,111 Plan(D18005 to FFH);the Key Technologies R&D Program of Guangdong Province(2023B1111030004 to FFH);the Guangdong Provincial Clinical Research Center for Kidney Disease(2020B1111170013 to FFH).
The ability of the mammalian kidney to repair or regenerate after acute kidney injury(AKI)is very limited.The maladaptive repair of AKI promotes progression to chronic kidney disease(CKD).Therefore,new strategies to p...
关键词：HYPOXIA prolyl hydroxylase domain inhibitor HIF-1α renal proximal tubular cells chemical reprogramming Sox9+renal progenitor cells renal regeneration 
Impact of SLC16A8 on tumor microenvironment and angiogenesis in colorectal cancer: New therapeutic target insights
《World Journal of Gastrointestinal Oncology》2025年第4期300-317,共18页Hong-Peng Tian Zhong-Xiang Xiao Bo-Wen Su Yi-Xuan Li Hong Peng Chang-Yuan Meng 
Supported by Nanchong Science and Technology Plan Project,No.23JCYJPT0064;Project of Sichuan Provincial Administration of Traditional Chinese Medicine,No.2024MS590。
BACKGROUND SLC16A8,a lactate efflux transporter,is upregulated in various cancers,but its effects on tumor microenvironments remain understudied.This research explores its role in colorectal cancer(CRC)and the impact ...
关键词：SLC16A8 Colorectal cancer HYPOXIA GLYCOLYSIS ANGIOGENESIS 
Risk Factors and Predictive Model for Acute Mountain Sickness among Han Chinese Travelers to Xizang Autonomous Region
《Biomedical and Environmental Sciences》2025年第4期506-510,共5页Qianhui Gong Qiong Li Zhichao Xu Xiaowei Chen Xiaobing Shen 
Acute mountain sickness(AMS) is an illness caused by hypoxia due to rapid ascent to altitudes above 2,500 m. Symptoms include headache,nausea, vomiting, and loss of appetite, all of which usually improve within 1 to 2...
关键词：risk factors Han Chinese travelers ALTITUDE HYPOXIA acute mountain sickness ams Xizang Autonomous Region SYMPTOMS acute mountain sickness 
Self-reporting hypoxia-responsive supramolecular phototheranostic nanomaterials based on AIEgen and azocalixarene
《Science China Chemistry》2025年第4期1550-1562,共13页Xiao-Wen Han Guo-Ling Zhang Pu Chen Jing Zhang Guogang Shan Chunxuan Qi Ben Zhong Tang Hai-Tao Feng 
supported by the National Natural Science Foundation of China(52173152 and 21805002);the Fund of the Rising Stars of Shaanxi Province(2021KJXX-48),the Research Foundation of Education Department of Shaanxi Province(21JK0487);the Young Talent Fund of University Association for Science and Technology in Shaanxi,China(20190610 and 20210606);the Scientific and Technological Innovation Team of Shaanxi Province(2022TD-36);All animal experiments were performed under the protocols approved by the Animal Care and Use Committee(Gansu University of Chinese Medicine)(GZRSQ2024-131).
Hypoxia is a significant feature in most of solid tumors.Hence;developing hypoxia-responsive phototheranostic system is still a challenge.In this contribution;a supramolecular assembly strategy based on sulfonate-func...
关键词：aggregation-induced emission host-guest interaction photodynamic therapy HYPOXIA BIOIMAGING 
Survival mechanisms of plants under hypoxic stress:Physiological acclimation and molecular regulation
《Journal of Integrative Plant Biology》2025年第3期440-454,共15页Lin-Na Wang Wei-Cheng Wang Ke Liao Ling-Jing Xu Dao-Xin Xie Ruo-Han Xie Shi Xiao 
supported by the Shenzhen Science and Technology Program(Project JCYJ20241202130044053);the National Key R&D Program of China(Project 2024YFD1200800);the National Natural Science Foundation of China(Projects 32321163646,U22A20458,and 32202468);the Natural Science Foundation of Guangdong Province(Project 2023A1515012038)。
Hypoxia(low-oxygen tension)caused by complete submergence or waterlogging is an abiotic stress factor that severely affects the yield and distribution of plants.To adapt to and survive under hypoxic conditions,plants ...
关键词：ERF-VIIs HYPOXIA protein kinases REOXYGENATION SUBMERGENCE 
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