Self-reporting hypoxia-responsive supramolecular phototheranostic nanomaterials based on AIEgen and azocalixarene  

作　　者：Xiao-Wen Han Guo-Ling Zhang Pu Chen Jing Zhang Guogang Shan Chunxuan Qi Ben Zhong Tang Hai-Tao Feng 

机构地区：[1]AIE Research Center,Shaanxi Key Laboratory of Phytochemistry College of Chemistry and Chemical Engineering,Baoji University of Arts and Sciences,Baoji 721013,China [2]National&Local United Engineering Laboratory for Power Batteries,Department of Chemistry,Northeast Normal University.Changchun 130024,China [3]School of Science and Engineering,Shenzhen Institute of Aggregate Science and Technology,The Chinese University of Hong Kong,Shenzhen(CUHK-Shenzhen),Shenzhen 518172,China

出　　处：《Science China Chemistry》2025年第4期1550-1562,共13页中国科学(化学英文版)

基　　金：supported by the National Natural Science Foundation of China(52173152 and 21805002);the Fund of the Rising Stars of Shaanxi Province(2021KJXX-48),the Research Foundation of Education Department of Shaanxi Province(21JK0487);the Young Talent Fund of University Association for Science and Technology in Shaanxi,China(20190610 and 20210606);the Scientific and Technological Innovation Team of Shaanxi Province(2022TD-36);All animal experiments were performed under the protocols approved by the Animal Care and Use Committee(Gansu University of Chinese Medicine)(GZRSQ2024-131).

摘　　要：Hypoxia is a significant feature in most of solid tumors.Hence;developing hypoxia-responsive phototheranostic system is still a challenge.In this contribution;a supramolecular assembly strategy based on sulfonate-functionalized azocalix[4]arene(SAC4A)and cationic aggregation-induced emission photosensitizer(namely TPA-H)was proposed for hypoxia-responsive bioimaging and photodynamic therapy(PDT).Upon supramolecular complexation of TPA-H and SAC4A through electrostatic interaction;the fluorescence and reactive oxygen species(ROS)generation of TPA-H were largely inhibited.In hypoxic tumors;the azo group of SAC4A can be reduced to aniline derivative and release the included TPA-H to recover its pristine fluorescence and ROS.Interestingly;the free TPA-H undergoes cell membrane-to-mitochondria translocation during cell imaging;achieving a real-time self-reporting PDT system.In vivo tumor imaging and therapy reveal that this as-prepared supramolecular complexes have good biosafety and efficient antitumor activity under hypoxia.Such hypoxia-responsive supramolecular photosensitizer system will enrich image-guided photodynamic therapy.

关 键 词：aggregation-induced emission host-guest interaction photodynamic therapy HYPOXIA BIOIMAGING 

分 类 号：O62[理学—有机化学]