REOXYGENATION

作品数：63被引量：320H指数：9
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相关领域：医药卫生更多>>
相关作者：刘颖陈琦叶诸榕陆锦标更多>>
相关机构：重庆医科大学附属第一医院复旦大学上海医学院华中科技大学南京市第一医院更多>>
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A vascular endothelial growth factor–loaded chitosan-hyaluronic acid hydrogel scaffold enhances the therapeutic effect of adipose-derived stem cells in the context of stroke
《Neural Regeneration Research》2025年第12期3591-3605,共15页Zhijian Zheng Xiaohui Lin Zijun Zhao Qiang Lin Ji Liu Manli Chen Wenwen Wu Zhiyun Wu Nan Liu Hongbin Chen 
supported by a grant from the Excellent Young Scholars Cultivation Project of Fujian Medical University Union Hospital,No.2022XH026(to HC);Joint Funds for the Innovation of Science and Technology in Fujian Province,No.2019Y9058(to XL);the Natural Science Foundation of Fujian Province,No.2020J011017(to XL)。
Adipose-derived stem cell,one type of mesenchymal stem cells,is a promising approach in treating ischemia-reperfusion injury caused by occlusion of the middle cerebral artery.However,its application has been limited b...
关键词：adipose-derived stem cells chitosan hyaluronic acid HYDROGEL ISCHEMIA-REPERFUSION oxygen-glucose deprivation/reoxygenation stroke transient middle cerebral artery occlusion TRANSPLANTATION vascular endothelial growth factor 
The demethylase FTO regulates the m6A modification and inflammation pathway in patients with cardiomyocytes after hypoxia-reoxygenation
《South China Journal of Cardiology》2024年第3期169-178,共10页ZHAO Hai-mei CHENG Hong JIAO Qi-hui 
supported by grants from Shenzhen Science and Technology Project(No.JCYJ20220531091817039)。
Background Myocardial ischemia-reperfusion injury is an important clinical problem.Hypoxia-reperfusion(HR)triggers a series of complex cellular reactions and pathological changes.In recent years,the role of N-6-methyl...
关键词：FTO m6A NF-k B IL-6 Anoxia and reoxygenation 
Effect of tubastatin A on NLRP3 inflammasome activation in macrophages under hypoxia/ reoxygenation conditions
《World Journal of Emergency Medicine》2024年第4期289-296,共8页Hao Li Chang Liu Ying Cui Panpan Chang Wei Chong 
supported by National Natural Science Foundation of China(82102315).
BACKGROUND:There are currently no effective drugs to mitigate the ischemia/reperfusion injury caused by fluid resuscitation after hemorrhagic shock(HS).The aim of this study was to explore the potential of the histone...
关键词：Hemorrhagic shock HYPOXIA/REOXYGENATION MACROPHAGE NLRP3 Tubastatin A 
Vav1 promotes inflammation and neuronal apoptosis in cerebral ischemia/reperfusion injury by upregulating microglial and NLRP3 inflammasome activation被引量：6
《Neural Regeneration Research》2023年第11期2436-2442,共7页Jing Qiu Jun Guo Liang Liu Xin Liu Xianhui Sun Huisheng Chen 
Natural Science Foundation of Liaoning Province (General Program),No.2017010825 (to JQ)。
Microglia,which are the resident macrophages of the central nervous system,are an important part of the inflammatory response that occurs after cerebral ischemia.Vav guanine nucleotide exchange factor 1(Vav1) is a gua...
关键词：apoptosis cerebral ischemia/reperfusion inflammatory cytokines microglia microglial activation middle cerebral artery occlusion neuroprotection NLRP3 inflammasome oxygen-glucose deprivation/reoxygenation Vav1 
Protective effect of ginsenoside Rg1 on 661W cells exposed to oxygen-glucose deprivation/reperfusion via keap1/nrf2 pathway
《International Journal of Ophthalmology(English edition)》2023年第7期1026-1033,共8页Ming Zhou Xin-Qi Ma Yi-Yu Xie Jia-Bei Zhou Xie-Lan Kuang Huang-Xuan Shen Chong-De Long 
Supported by Natural Science Foundation of Guangdong Province(No.2021A1515010513)。
AIM:To construct an in vitro model of oxygen-glucose deprivation/reperfusion(OGD/R)induced injury to the optic nerve and to study the oxidative damage mechanism of ischemia-reperfusion(I/R)injury in 661W cells and the...
关键词：oxygen-glucose deprivation/reoxygenation ginsenoside Rg1 oxidative stress phosphorylated nrf2 
Upregulation of CDGSH iron sulfur domain 2 attenuates cerebral ischemia/reperfusion injury被引量：1
《Neural Regeneration Research》2023年第7期1512-1520,共9页Miao Hu Jie Huang Lei Chen Xiao-Rong Sun Zi-Meng Yao Xu-Hui Tong Wen-Jing Jin Yu-Xin Zhang Shu-Ying Dong 
supported by the National Natural Science Foundation of China,No.81402930;Natural Science Foundation of Universities in Anhui Province,No.KJ2021A0688;National College Students Innovation and Entrepreneurship Program,No.202110367071;Key projects of science and technology projects of Bengbu Medical College,No.2020byzd017;512 Talents Training Program of Bengbu Medical College,No.BY51201104(all to SYD).
CDGSH iron sulfur domain 2 can inhibit ferroptosis,which has been associated with cerebral ischemia/reperfusion,in individuals with head and neck cancer.Therefore,CDGSH iron sulfur domain 2 may be implicated in cerebr...
关键词：cerebral ischemia/reperfusion injury CDGSH iron sulfur domain 2 ferroptosis glutathione peroxidase 4 heme oxygenase 1 HT22 nuclear-factor E2-related factor 2 oxygen-glucose deprivation/reoxygenation injury stroke transferrin receptor 1 
Neuroprotective effects of neural stem cells pretreated with neuregulin1β on PC12 cells exposed to oxygen-glucose deprivation/reoxygenation被引量：4
《Neural Regeneration Research》2023年第3期618-625,共8页Qiu-Yue Zhai Yuan-Hua Ye Yu-Qian Ren Zhen-Hua Song Ke-Li Ge Bao-He Cheng Yun-Liang Guo 
supported by the National Natural Science Foundation of China,No.81973501;the Natural Science Foundation of Shandong Province,No.ZR2019MH009(both to YLG).
Studies on ischemia/reperfusion(I/R)injury suggest that exogenous neural stem cells(NSCs)are ideal candidates for stem cell therapy reperfusion injury.However,NSCs are difficult to obtain owing to ethical limitations....
关键词：ferroptosis P53 SLC7A11 GPX4 human umbilical cord-mesenchymal stem cells neural stem cells neuregulin1β NEUROPROTECTION oxygen-glucose deprivation/reoxygenation PC12 cell 
Tilianin extracted from Xiangqinglan(Herba Dracocephali Moldovicae)inhibits apoptosis induced by mitochondrial pathway and endoplasmic reticulum stress in H9c2 cells after oxygen-glucose deprivation/reoxygenation被引量：2
《Journal of Traditional Chinese Medicine》2023年第1期42-50,共9页JIANG Wen ZHANG Wei ZHANG Yuxiang YANG Hao PAN Xiaomei CHEN Qiang CHEN Junhui 
Supported by the National Natural Science Foundation:Mechanisms of the Protective Effects of Tilianin Against Myocardium Ischemia/Reperfusion Injury Through Ox-CaMKII-mediated Mitochondrial Regulating Pathway(No.81760045);the Xinjiang Uygur Natural Science Foundation of Autonomous Region:Study on the Mechanism of Tilianin Anti-atherosclerosis Effect of Tealis via the Reverse Cholesterol Transport Pathway(No.2018D01C317);the Chinese Medical Association Clinical Pharmacy Branch-Wu Jieping Medical Foundation:Study on the Mechanism of Tilianin Mediate Mitochondrial Function to Regulate Endoplasmic Reticulum Stress and Participate in Anti-myocardial Ischemia/Reperfusion Injury(No.320.6750.2020-04-32)。
OBJECTIVE:To investigate the efficacy of tilianin extracted from Xiangqinglan(Herba Dracocephali Moldovicae)on apoptosis of H9c2 cell after oxygenglucose deprivation/reoxygenation(OGD/R)and the mechanism.METHODS:Tilia...
关键词：APOPTOSIS MITOCHONDRIA endoplasmic reticulum stress tilianin oxygen-glucose deprivation/reoxygenation 
Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis被引量：40
《Military Medical Research》2022年第6期668-685,共18页Xue Zeng Yun-Dong Zhang Rui-Yan Ma Yuan-Jing Chen Xin-Ming Xiang Dong-Yao Hou Xue-Han Li He Huang Tao Li Chen-Yang Duan 
supported by the National Natural Science Foundation of China (81700429);the China Postdoctoral Science Foundation (2021MD703924);the Chongqing Postdoctoral Innovative Talents Support Program (CQBX2021018);the Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University。
Background: Cerebral ischemia-reperfusion injury(CIRI) refers to a secondary brain injury that can occur when the blood supply to the ischemic brain tissue is restored. However, the mechanism underlying such injury re...
关键词：Cerebral ischemia-reperfusion(CIRI) Oxygen-glucose deprivation/reoxygenation(OGD/R) Drp1 P62 LC3 II/I Reactive oxygen species(ROS) RIP1/RIP3 Autophagy EXOSOME Inflammatory 
Silencing miRNA-324-3p protects against cerebral ischemic injury via regulation of the GATA2/A1R axis被引量：3
《Neural Regeneration Research》2022年第11期2504-2511,共8页An-Qi Zhang Lu Wang Yi-Xiu Wang Shan-Shan Hong Yu-Shan Zhong Ru-Yi Yu Xin-Lu Wu Bing-Bing Zhou Qi-Min Yu Hai-Feng Fu Shuang-Dong Chen Yun-Chang Mo Qin-Xue Dai Jun-Lu Wang 
funded by the National Natural Science Foundation of China,No.81803937(to YCM and QXD);Science and Technology Innovation Activity Plan for College Students of Zhejiang Province(Xinmiao Talent Plan),No.2020R413079(to AQZ);Wenzhou Science and Technology Plan Project,No.Y20210122(to QXD)。
Previous studies have suggested that miR-324-3p is related to the pathophysiology of cerebral ischemia,but the mechanism underlying this relationship is unclea r.In this study,we found that miR-324-3p expression was d...
关键词：acute ischemic stroke adenosine A1 receptor apoptosis cerebral ischemia-reperfusion injury cortical neurons GATA2 middle cerebral artery occlusion miR-324-3p oxygen-glucose deprivation/reoxygenation PC12 cells 
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