HYPOXIA/REOXYGENATION

作品数：41被引量：146H指数：7
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相关领域：医药卫生更多>>
相关作者：杨轶罗伟波王逸平芮耀诚李铁军更多>>
相关机构：大连医科大学重庆医科大学广东省人民医院中国科学院上海生命科学研究院更多>>
相关期刊：《Hepatobiliary & Pancreatic Diseases International》《Chinese Medical Journal》《Journal of Hainan Medical University》《China Medical Abstracts(Internal Medicine)》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划天津市自然科学基金国家教育部博士点基金更多>>
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Cav3.2 channel regulates cerebral ischemia/reperfusion injury:a promising target for intervention被引量：2
《Neural Regeneration Research》2024年第11期2480-2487,共8页Feibiao Dai Chengyun Hu Xue Li Zhetao Zhang Hongtao Wang Wanjun Zhou Jiawu Wang Qingtian Geng Yongfei Dong Chaoliang Tang 
supported by the Natural Science Foundation of Anhui Province of China,No.2208085Y32;Scientific Research Plan Project of Anhui Province of China,No.2022AH020076;the Chen Xiao-Ping Foundation for the Development of Science and Technology of Hubei Province,No.CXPJJH12000005-07-115(all to CT).
Calcium influx into neurons triggers neuronal death during cerebral ischemia/reperfusion injury.Various calcium channels are involved in cerebral ischemia/reperfusion injury.Cav3.2 channel is a main subtype of T-type ...
关键词：CALCINEURIN Cav3.2 channel cerebral ischemia/reperfusion hippocampus HYPOXIA/REOXYGENATION inflammatory response nuclear factor of activated T cells 3 oxidative stress primary hippocampal neurons stroke 
Effect of tubastatin A on NLRP3 inflammasome activation in macrophages under hypoxia/ reoxygenation conditions
《World Journal of Emergency Medicine》2024年第4期289-296,共8页Hao Li Chang Liu Ying Cui Panpan Chang Wei Chong 
supported by National Natural Science Foundation of China(82102315).
BACKGROUND:There are currently no effective drugs to mitigate the ischemia/reperfusion injury caused by fluid resuscitation after hemorrhagic shock(HS).The aim of this study was to explore the potential of the histone...
关键词：Hemorrhagic shock HYPOXIA/REOXYGENATION MACROPHAGE NLRP3 Tubastatin A 
Anisodine hydrobromide alleviates oxidative stress caused by hypoxia/reoxygenation in human cerebral microvascular endothelial cells predominantly via inhibition of muscarinic acetylcholine receptor 4
《BIOCELL》2023年第10期2255-2263,共9页WENLI JIANG JUNYI SHEN XIAOQIANG DU YAN QIU JIAN ZHONG ZHI OUYANG BINGMEI M.FU YE ZENG 
funding from the National Natural Science Foundation of China(12272246);the Key Research and Development Projects of Sichuan Province(2023YFS0075).
Background:Anisodine hydrobromide(AT3),an anti-cholinergic agent,could be delivered to the brain across the blood-brain barrier and has been used clinically for the treatment of cerebral ischemia/reperfusion injury.En...
关键词：HYPOXIA/REOXYGENATION Endothelial cell Anisodine hydrobromide Muscarinic acetylcholine receptors Hypoxia-inducible factor-1α 
Protective Effects of Six PPTs on Hypoxia/Reoxygenation Induced Cardiomyocyte Injury by Different Treatments
《Medicinal Plant》2022年第5期66-69,73,共5页Tingbo CHEN Dong HUANG Ziming ZHOU Gengting DONG 
Supported by General Colleges and Universities Youth Innovative Talents Project of Guangdong Province(2019GKQNCX134);Guangdong Doctoral Workstation Funds。
[Objectives]To detect the protective effects of six protopanaxatriols(PPTs)on hypoxia/reoxygenation(H/R)induced cardiomyocyte injury by different treatments.[Methods]The 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetra...
关键词：Protopanaxatriols(PPTs) Ginsenoside Rg1 Mitochondrial function Treatment process 
Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia被引量：10
《Military Medical Research》2022年第3期286-302,共17页Rong-Hui Han He-Meng Huang Hong Han Hao Chen Fei Zeng Xiang Xie Dan-Yong Liu Yin Cai Liang-Qing Zhang Xin Liu Zheng-Yuan Xia Jing Tang 
supported by the National Natural Science Foundation of China grant (NSFC81970247)。
Background:Administration of propofol,an intravenous anesthetic with antioxidant property,immediately at the onset of post-ischemic reperfusion(propofol postconditioning,P-PostC) has been shown to confer cardioprotect...
关键词：Hypoxia/reoxygenation injury HYPERGLYCEMIA High glucose Propofol postconditioning Apoptosis AUTOPHAGY Forkhead box O 
Protective effect of resveratrol on rat cardiomyocyte H9C2 cells injured by hypoxia/reoxygenation by regulating mitochondrial autophagy via PTEN-induced putative kinase protein 1/Parkinson disease protein 2 signaling pathway被引量：3
《Journal of Traditional Chinese Medicine》2022年第2期176-186,共11页ZHAO Lixia SUN Wei BAI Decheng 
Supported by the Open Fund of Key Laboratory of Dunhuang Medicine,Ministry of Education(DHYX20-09);the Youth Research Foundation of the Gansu University of Chinese Medicine(No.ZQ2017-14)。
OBJECTIVE:To investigate the protective effect of resveratrol on cardiomyocytes after hypoxia/reoxygenation intervention based on PTEN-induced putative kinase protein 1/Parkinson disease protein 2(PINK1/PARKIN)signali...
关键词：RESVERATROL MYOCYTES cardiac hypoxia PTEN phosphohydrolase Parkinson disease associated proteins mitochondrial autophagy 
Effects of Qishen Yiqi dripping pills-containing serum on KATP channel opening and PI3K/AKT signaling pathway in hypoxic/reoxygenated H9C2 cardiocytes
《Journal of Hainan Medical University》2022年第6期12-18,共7页Gui-Xin He Yu-Fei Feng Wei-Bin Qin Lin Lin Meng-Xian Hu Guo-Kun Zheng Li-Yan Yu Zi-Yong Jia Juan Wei Qi Wen 
Regional Fund Project of National Natural Science Foundation of China(No.81460712);the Young and Middle-aged Teachers’Scientific Research Basic Ability Enhancement Project of Guangxi Universities(No.2020KY07026);Guangxi Graduate Education Innovation Program(No.YCXJ2021035)。
Objective:To investigate the effects of Qishen Yiqi dropping pills serum on KATP channel opening and PI3K/AKT signaling pathway of hypoxic/reoxygenated H9C2 cardiocytes.Methods:H9C2 cardiocytes cultured in vitro were ...
关键词：Qishen Yiqi dropping pills H9C2 HYPOXIA/REOXYGENATION P-AKT mitoKATP 
Cystic fibrosis transmembrane conductance regulator prevents ischemia/reperfusion induced intestinal apoptosis via inhibiting PI3K/AKT/NF-κB pathway被引量：3
《World Journal of Gastroenterology》2022年第9期918-932,共15页Zhi-Wei Dong Hui Liu Fei-Fei Su Xiao-Zhou Fan Yong Zhang Peng Liu 
Supported by National Natural Science Foundation of China, No.81800473;"Young Eagle Project"of Air Force Medical University, No.KT2021DX007
BACKGROUND Intestinal ischemia/reperfusion(I/R)injury is a fatal syndrome that occurs under many clinical scenarios.The apoptosis of intestinal cells caused by ischemia can cause cell damage and provoke systemic dysfu...
关键词：APOPTOSIS Cystic fibrosis transmembrane conductance regulator Intestinal ischemia-reperfusion injury PI3K/AKT/NF-κB HYPOXIA/REOXYGENATION Caco2 cells 
Interleukin 35 protects cardiomyocytes following ischemia/reperfusion-induced apoptosis via activation of mitochondrial STAT3被引量：3
《Acta Biochimica et Biophysica Sinica》2021年第4期410-418,共9页Fengyun Zhou Ting Feng Xiangqi Lu Huicheng Wang Yangping Chen Qiuxia Zhang Xinlu Zhang Jiancheng Xiu 
This work was supported by the grants from the National Natural Science Foundation of China(Nos.81974266,81470598,and 81800371);the National Key R&D Program of China(No.2018 YFC1312803).
Mitochondrial reactive oxygen species(mtROS)-induced apoptosis has been suggested to contribute to myocardial ischemia/reperfusion injury.Interleukin 35(IL-35),a novel anti-inflammatory cytokine,has been shown to prot...
关键词：apoptosis HYPOXIA/REOXYGENATION IL-35 ROS STAT3 
Effect of hypoxia/reoxygenation on the viability expression of ROS and MAPKs in myocardial cells
《Journal of Hainan Medical University》2021年第7期1-5,共5页Xue-Bin Ling Jun Wang Miao-Miao Qi Ji-Ke Li Jun-Li Guo Tian-Fa Li 
The foundation project of national natural science [No.(2018)40]。
Objective:To investigate to the expression effect of hypoxia and hypoxia/reoxygenation on ROS,MAPKs and cell apoptosis in H9c2 cardiomyocytes.Methods:H9c2 cells were treated with cobalt chloride(CoCl2)to establish the...
关键词：HYPOXIA/REOXYGENATION Reactive oxygen species Mitogen-activated protein kinases Cobalt chloride CARDIOMYOCYTE 
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