MYOCYTES

作品数：87被引量：319H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：郭慧淑禹永春李英许文燮吴博威更多>>
相关机构：延边大学山西医科大学上海市徐汇区中心医院河北医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划上海市自然科学基金国家高技术研究发展计划更多>>
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A recombinant fragment antigen-binding(Fab)of trastuzumab displays low cytotoxic profile in adult human cardiomyocytes:first evidence and the key implication of FcγRIIA receptor
《Acta Pharmacologica Sinica》2025年第3期618-631,共14页Anna De Bartolo Naomi Romeo Alessandro Marrone Vittoria Rago Maria Concetta Granieri Maria Luigia Vommaro Arianna Cupelli Maria Carmela Cerra Cesare Indiveri Raffaele Ronca Maria Cantile Riccardo Sanna Carmine Rocca Tommaso Angelone 
supported by“SI.F.I.PA.CRO.DE.–Sviluppo e industrializzazione farmaci innovativi per terapia molecolare personalizzata PA.CRO.DE”(PON ARS01_00568).
Fragment crystallizable gamma receptors(FcγRs)mediate various cellular responses with significant cardiovascular implications.They contribute to the anticancer activity of trastuzumab(TRZ),a recombinant humanized mon...
关键词：cardiac complications TRASTUZUMAB rFab-HER2 Fc region FcyRIIA HER2 
Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis被引量：2
《Acta Pharmacologica Sinica》2024年第4期728-737,共10页Wei Wang Xiao-kang Chen Lu Zhou Feng Wang Yan-ji He Bing-jun Lu Ze-gang Hu Zhu-xin Li Xue-wei Xia Wei Eric Wang Chun-yu Zeng Liang-peng Li 
supported by grants from the National Natural Science Foundation of China(81930008,81900792);the Natural Science Foundation of Chongqing(2023NSCQ-MSX2101);the National Key R&D Program of China(2018YFC1312700);the Program of Innovative Research Team by the National Natural Science Foundation(81721001);the Program for Changjiang Scholars and Innovative Research Team in University;IRT1216.
Stimulation of adult cardiomyocyte proliferation is a promising strategy for treating myocardial infarction(MI).Earlier studies have shown increased CCL2 levels in plasma and cardiac tissue both in MI patients and mou...
关键词：myocardial infarction CCL2 cardiomyocyte proliferation Bindarit STAT3 PF-4136309 stattic neonatal rat ventricle myocytes 
Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes被引量：3
《Signal Transduction and Targeted Therapy》2023年第1期10-12,共3页Rayhane Nchioua Federica Diofano Sabrina Noettger Pascal von Maltitz Steffen Stenger Fabian Zech Jan Münch Konstantin M.J.Sparrer Steffen Just Frank Kirchhoff 
supported by the DFG(CRCs 1279 and 1506);the EU commission(Fight-nCoV);the MWK and the BMBF(Restrict-SARS-CoV-2,IMMUNOMOD).
Dear Editor,Since its first description in South Africa in November 2021,the SARS-CoV-2 Omicron variant rapidly outcompeted the previously dominating Delta variant.Omicron is the fifth variant of concern(VOC).It conta...
关键词：STRONG neutral OMI 
Profiling the responsiveness of focal adhesions of human cardiomyocytes to extracellular dynamic nano-topography被引量：1
《Bioactive Materials》2022年第4期367-377,共11页Huaiyu Shi Xiangjun Wu Shiyang Sun Chenyan Wang Zacharias Vangelatos Ariel Ash-Shakoor Costas P.Grigoropoulos Patrick T.Mather James H.Henderson Zhen Ma 
supported by the NIH NICHD[R01HD101130];NSF[CBET-1804875,CBET-1943798 and CMMI-2130192];NSF[DMR-1609523 and CMMI-2022421];Syracuse University intramural CUSE Grant;Gerber Grant;BioInspired Institute Seed Grant.
Focal adhesion complexes function as the mediators of cell-extracellular matrix interactions to sense and transmit the extracellular signals.Previous studies have demonstrated that cardiomyocyte focal adhesions can be...
关键词：Stimuli-responsive biomaterials Shape memory polymer Focal adhesion Costamere Dynamic mechanobiology Human induced pluripotent stem cells 
Protective effect of resveratrol on rat cardiomyocyte H9C2 cells injured by hypoxia/reoxygenation by regulating mitochondrial autophagy via PTEN-induced putative kinase protein 1/Parkinson disease protein 2 signaling pathway被引量：3
《Journal of Traditional Chinese Medicine》2022年第2期176-186,共11页ZHAO Lixia SUN Wei BAI Decheng 
Supported by the Open Fund of Key Laboratory of Dunhuang Medicine,Ministry of Education(DHYX20-09);the Youth Research Foundation of the Gansu University of Chinese Medicine(No.ZQ2017-14)。
OBJECTIVE:To investigate the protective effect of resveratrol on cardiomyocytes after hypoxia/reoxygenation intervention based on PTEN-induced putative kinase protein 1/Parkinson disease protein 2(PINK1/PARKIN)signali...
关键词：RESVERATROL MYOCYTES cardiac hypoxia PTEN phosphohydrolase Parkinson disease associated proteins mitochondrial autophagy 
miR-130b inhibits proliferation and promotes differentiation in myocytes via targeting Sp1被引量：5
《Journal of Molecular Cell Biology》2021年第6期422-432,共11页Yu-Cheng Wang Xiaohan Yao Mei Ma Huihui Zhang Hui Wang Lei Zhao Shengnan Liu Chao Sun Peng Li Yuting Wu Xihua Li Jingjing Jiang Yuying Li Yan Li Hao Ying 
This work was supported by grants from the National Natural Science Foundation of China(81570768 to Y.-C.W.,31900841 to Yan Li,91957205 and 31525012 to H.Y.,and 81471016 to J.J.);the Ministry of Science and Technology of China(2016YFA0500102 and 2016YFC1304905);CAS Key Laboratory of Nutrition,Metabolism and Food Safety(KLNMFS2019-01),and Chinese Academy of Sciences Interdisciplinary Innovation Team.
Muscle regeneration after damage or during myopathies requires a fine cooperation between myoblast proliferation and myogenic differentiation.A growing body of evidence suggests that microRNAs play critical roles in m...
关键词：miR-130b muscle regeneration PROLIFERATION DIFFERENTIATION SP1 
Efficacy of water fraction from Dioscorea cirrhosa on oxidative stress and apoptosis in H9c2 cardiomyocytes induced by H2O2被引量：4
《Journal of Traditional Chinese Medicine》2021年第1期51-58,共8页LIU Chunhua PAN Jie WANG Aimin LAN Yanyu LI Yongjun LU Yuan SUN Jia WANG Yonglin LIU Ting LU Dingyan YOU Jingrui 
Supported by National Natural Science Foundation of China Basic Research on Ethnopharmacology of Guizhou Karst Area(No.U1812403);Study on the Active Components of Anti-oxidative Stress Activities of Shengxiong Glucose Injection Based on Pi3k/akt Pathway(No.81760699);Investigation of The Active Components and Mechanism of Polygonum Orientale Ameliorating Myocardial Ischemic Injury Based on"Components-Network Targets-Effects"(No.81803700);Central Guided Local Science and Technology Special Project Capability Enhancement of Guizhou Provincial Key Laboratory of Pharmaceutics(No.20184006);Guizhou Provincial Natural Science Foundation Effects of Gerbera Piloselloides on Airway Inflammation in Bronchial Asthma and Its Medicinal Substance Basis(20181128);Study on the Molecular Mechanism and Active Ingredients of Polygonum Orientale in Treating Myocardial Ischemic Disease Based on Systemic Pharmacology Strategy(No.20201z068);Guizhou Provincial People’s Pharmacy Effective Material Basic Research Science and Technology Innovation Talent Team(No.20165613);Cultivation of High-level Innovative Talents in Guizhou Province(Hundred Levels)(No.20165677);Study on the Effective Component Group and Its Mechanism of Anti-myocardial Ischemia Injury of Polygonum Orientale Based on"Component-network Target"(No.20175718);Study on the Effective Material Basis of Shengxiong Glucose Injection for Its Anti-oxidative Stress Activities Mediated by Pi3k/akt(No.20191280);Doctoral Start Fund of Guizhou Medical University Study on the Effective Material Basis of Gerbera Piloselloides Against Bronchial Asthma Based on In Vivo Processes(No.YJ2017-12)。
OBJECTIVE:To investigate the efficacy of water fraction from Dioscorea cirrhosa(WF)on oxidative damage and apoptosis of cardiomyocytes induced by H2O2,and to study its mechanism.METHODS:Cell viability was measured by ...
关键词：DIOSCOREA water fraction hydrogen peroxide oxidative stress APOPTOSIS myocytes cardiac 
Probing the subcellular nanostructure of engineered human cardiomyocytes in 3D tissue
《Microsystems & Nanoengineering》2021年第1期133-140,共8页Josh Javor Jourdan K.Ewoldt Paige E.Cloonan Anant Chopra Rebeccah J.Luu Guillaume Freychet Mikhail Zhernenkov Karl Ludwig Jonathan G.Seidman Christine E.Seidman Christopher S.Chen David J.Bishop 
supported by NSF CELL-MET ERC award no.1647837 and NSF GRFP(DGE-1840990,J.K.E.)。
The structural and functional maturation of human induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs)is essential for pharmaceutical testing,disease modeling,and ultimately therapeutic use.Multicellular 3D...
关键词：cardiac CARDIOMYOCYTES SPACING 
The cardiovascular protective effect and mechanism of calycosin and its derivatives被引量：6
《Chinese Journal of Natural Medicines》2020年第12期907-915,共9页PAN Li ZHANG Xuan-Fen WEI Wan-Sheng ZHANG Jing LI Zhen-Zhen 
Cardiovascular disease is the main cause of mortality and morbidity in the world,especially in developing countries.Drug therapy is one of the main ways to treat cardiovascular diseases.Among them,great progress has b...
关键词：Cardiovascular disease CALYCOSIN Cadiac myocytes Vascular endothelial cells Protective effect 
Minimal contribution of IP_(3)R2 in cardiac differentiation and derived ventricular-like myocytes from human embryonic stem cells
《Acta Pharmacologica Sinica》2020年第12期1576-1586,共11页Peng Zhang Ji-jun Huang Kun-fu Ou-yang He Liang Miao-ling Li Yi-jie Wang Huang-tian Yang 
This work was supported by grants from National Key R&D Program of China(2017YFA0103700 and 2016YFC1301204 to HTY);National Natural Science Foundation of China(81520108004,81470422 to HTY);the Strategic Priority Research Program of the CAS(No.XDA16010201 to HTY);Shanghai Natural Science Foundation(17ZR1435500 to JJH),and the Shenzhen Basic Research Foundation(KQJSCX20170330155020267).
Type 2 inositol 1,4,5-trisphosphate receptor(IP_(3)R2)regulates the intracellular Ca^(2+)release from endoplasmic reticulum in human embryonic stem cells(hESCs),cardiovascular progenitor cells(CVPCs),and mammalian car...
关键词：IP_(3)R2 human embryonic stem cells differentiation cardiovascular progenitor cells CARDIOMYOCYTES function 
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