CARDIOMYOCYTES

作品数：238被引量：960H指数：15
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相关作者：单志新钟慈声杨宝峰刘恭鑫魏丕敬更多>>
相关机构：中国科学院上海生命科学研究院上海医科大学附属中山医院广东省心血管病研究所广东省人民医院更多>>
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MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model
《World Journal of Stem Cells》2025年第3期81-101,共21页Jing-Jun Jin Rong-Hua Liu Jin-Yan Chen Kun Wang Jun-Yong Han Dao-Shun Nie Yu-Qing Gong Bin Lin Guo-Xing Weng 
Supported by the Nonprofit Research Institutes Foundation of Fujian Province,China,No.2021R1012005 and No.2021R1012003.
BACKGROUND Heart disease remains a leading cause of mortality worldwide,with existing treatments often failing to effectively restore damaged myocardium.Humaninduced pluripotent stem cells(hiPSCs)and their derivatives...
关键词：Human-induced pluripotent stem cells Human-induced pluripotent stem cell-derived cardiomyocytes Myocardial infarction EXOSOMES MicroRNA 21-5p Apoptosis 
Assessment of the biosafety profile of Galium verum in vitro on myoblasts and in ovo on chorioallantoic membrane
《World Journal of Cardiology》2025年第2期71-84,共14页Diana Maria Morariu-Briciu Sorin Lucian Bolintineanu Andreea Rata Alexandra Denisa Semenescu Alina Anton Robert Jijie Andreea Kis Ingrid Hrubaru Alina Heghes 
BACKGROUND Cardiovascular diseases are the first cause of death in the world.Ischemic heart disease is the main cause of heart failure.New approaches are continuously sou-ght to identify better therapeutic success.The...
关键词：Galium verum L Ethanolic extract CARDIOMYOCYTES Ischemic heard Cellular viability stimulation In vitro In ovo 
EEPD1 attenuates radiation-induced cardiac hypertrophy and apoptosis by degrading FOXO3A in cardiomyocytes
《Acta Biochimica et Biophysica Sinica》2024年第12期1733-1747,共15页Kaiwen Yu Xi Su Tongfang Zhou Xuwei Cai Min Zhang 
supported by the grants from the National Natural Science Fund of China(Nos.82172156 and 82273575).
Radiation-induced heart disease(RIHD)is a severe delayed complication of thoracic irradiation(IR).Endonuclease/exonuclease/phosphatase family domain-containing 1(EEPD1)plays an important role in DNA damage repair,but ...
关键词：EEPD1 radiation-induced heart disease cardiac hypertrophy APOPTOSIS FOX03A 
Emerging biotechnologies for screening electromechanical signals of cardiomyocytes
《Aggregate》2024年第6期6-22,共17页Si Tang Lingyu Sun Huiyao Shi Kaixuan Wang Jialin Shi Chanmin Su Yuanjin Zhao Lianqing Liu 
Youth Innovation Promotion Association of the Chinese Academy of Sciences,Grant/Award Number:2021197;National Natural Science Foundation of China,Grant/Award Numbers:61925307,61927805,62127811;National Key Research and Development Program of China,Grant/Award Number:2021YFB3201600。
Cardiac diseases threaten human health and burden the global healthcare system.Cardiomyocytes(CMs)are considered the ideal model for studying the signal transduction and regulation of cardiac systems.Based on the prin...
关键词：biosensing platform CARDIOMYOCYTE electrical signal mechanical signal 
ZEB1-AS1 as a TRPML1 Inhibitor to Cause Lysosome Dysfunction and Cardiac Damage in Aged Mice
《Engineering》2024年第12期183-200,共18页Heng Liu Haiying Zhang Han Lou Jennifer Wang Shengxin Hao Hui Chen Chen Chen Lei Wang Huimin Li Ziyu Meng Wenjie Zhao Tong Zhao Yuan Lin Zhimin Du Xin Liu Baofeng Yang Yong Zhang 
funded by the National Natural Science Foundation of China(82273919,82270396,and U21A20339);the China Postdoctoral Science Foundation(2023T160176)。
The prevalence of cardiovascular diseases(CVDs)has increased markedly as the world population has aged.Long non-coding RNAs(lncRNAs)have been reported as novel regulators in diverse pathophysiological conditions.Here,...
关键词：Heart aging Cardiomyocytes senescence ZEB1-AS1 TRPML1 LYSOSOME 
In situ reprogramming of cardiac fibroblasts into cardiomyocytes in mouse heart with chemicals
《Acta Pharmacologica Sinica》2024年第11期2290-2299,共10页Zi-yang Chen Si-jia Ji Chen-wen Huang Wan-zhi Tu Xin-yue Ren Ren Guo Xin Xie 
supported by grants from the Ministry of Science and Technology of China(2022YFA1104700 and 2022ZD0204700 to XX);the National Natural Science Foundation of China(82121005 and 82330113 to XX,31900518 to CWH);Youth Innovation Promotion Association of the Chinese Academy of Sciences(2022280 to RG);Fundamental Research Projects of Science&Technology Innovation and Development Plan in Yantai City(2023JCYJ063 to RG);Taishan Scholars Program to XX.
Cardiomyocytes are terminal differentiated cells and have limited ability to proliferate or regenerate.Condition like myocardial infarction causes massive death of cardiomyocytes and is the leading cause of death.Prev...
关键词：cardiac transdifferentiation in situ transdifferentiation small molecules CARDIOMYOCYTES FIBROBLASTS in vivo transdifferentiation 
The demethylase FTO regulates the m6A modification and inflammation pathway in patients with cardiomyocytes after hypoxia-reoxygenation
《South China Journal of Cardiology》2024年第3期169-178,共10页ZHAO Hai-mei CHENG Hong JIAO Qi-hui 
supported by grants from Shenzhen Science and Technology Project(No.JCYJ20220531091817039)。
Background Myocardial ischemia-reperfusion injury is an important clinical problem.Hypoxia-reperfusion(HR)triggers a series of complex cellular reactions and pathological changes.In recent years,the role of N-6-methyl...
关键词：FTO m6A NF-k B IL-6 Anoxia and reoxygenation 
Magnesium lithospermate B enhances the potential of human-induced pluripotent stem cell-derived cardiomyocytes for myocardial repair
《Chinese Medical Journal》2024年第15期1857-1869,共13页Chengming Fan Kele Qin Chukwuemeka Daniel Iroegbu Kun Xiang Yibo Gong Qing Guan Wenxiang Wang Jun Peng Jianjun Guo Xun Wu Jinfu Yang 
supported by the Natural Science Foundation of Hunan Province(Nos.2023JJ30793,2022JJ20088,and 2019JJ50858);the Science and Technology Innovation Program of Hunan Province(No.2021RC2106);the National Natural Science Foundation of China(No.82200323);the Scientific Research Launch Project for new employees of the Second Xiangya Hospital of Central South University.
Background:We previously reported that activation of the cell cycle in human-induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs)enhances their remuscularization capacity after human cardiac muscle patch tr...
关键词：Myocardial infarction Cell therapy Induced pluripotent stem cells Magnesium lithospermate B CARDIOMYOCYTE Disease modeling hiPSC-CMs 
Glycnsisitin A:A promising bicyclic peptide against heart failure that facilitates TFRCmediated uptake of iron in cardiomyocytes被引量：2
《Acta Pharmaceutica Sinica B》2024年第7期3125-3139,共15页Jichao Zhou Yuanyuan Liu Xiaoli Wei Meng Yuan Xu Zhang Lingfeng Qin Bing Cui Pingping Li Jing Zhang Ziming Feng Jianshuang Jiang Xiang Yuan Ruibing Xu Zhimeng Zhang Peicheng Zhang Xiaowei Zhang Yanan Yang 
supported by Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2022-I2M-2-002,2021-I2M-1-016,and 2022-I2M-1-014,China);the Beijing Outstanding Young Scientist Program(BJJWZYJH01201910023028,China);Chinese Academy of Medical Sciences(CAMS)Central Public-interest Scientific Institution Basal Research Fund(2018PT35004,Molecular Mechanism and Target Discovery of Metabolic Disorder and Tumorigenesis,CAMS Key Laboratory).
Zhigancao decoction is a traditional prescription for treating irregular pulse and palpitations in China.As the monarch drug of Zhigancao decoction,the bioactive molecules of licorice against heart diseases remain elu...
关键词：Glycyrrhiza uralensis Bicyclic peptides Myocardial energy metabolism Iron homeostasis TFRC 
Transient induction of actin cytoskeletal remodeling associated with dedifferentiation,proliferation,and redifferentiation stimulates cardiac regeneration被引量：1
《Acta Pharmaceutica Sinica B》2024年第6期2537-2553,共17页Wenbin Fu Qiao Liao Yu Shi Wujian Liu Hongmei Ren Chunmei Xu Chunyu Zeng 
supported by the grant to Chunyu Zeng from the National Key R&D Program of China(2022YFA1104500);the National Natural Science Foundation of China(82200307);the grant to Chunyu Zeng from the National Natural Science Foundation of China(81930008).
The formation of new and functional cardiomyocytes requires a 3-step process:dedifferentiation,proliferation,and redifferentiation,but the critical genes required for efficient dedifferentiation,proliferation,and redi...
关键词：Single cell analysis Actin remodeling Tmsb4x Tmsb10 Dmd Ctnna3 Myocardial infarction Cardiomyocytes proliferation Cardiac regeneration Genetic therapy 
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