该研究旨在探讨心阳片调控脂肪量和肥胖相关蛋白(fat mass and obesity-associated protein,FTO)/N6-甲基腺嘌呤(N6-methyladenosine,m6A)信号通路改善心力衰竭(heart failure,HF)心室重构的作用机制。体内研究采用主动脉弓缩窄术(trans...
supported by the Natural National Science Foundation of China(No.81972373).
The progression of numerous malignancies has been linked to N6-methyladenosine(m6A)alteration.However,the opposite trend of m6A levels in the development and metastasis of cancer has not been reported.This study aimed...
financially supported by the National Natural Science Foundation of China (No.82100251).
N^(6)-methyladenosine(m^(6)A)RNA methylation exerts significant functions in regulating various cardiovascular diseases.Following the recognition of the first m^(6)A demethylase,namely fat and obesity-associated prote...