EXOSOMES

作品数：703被引量：2687H指数：22
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Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury
《Neural Regeneration Research》2025年第11期3273-3286,共14页Shiming Li Jianfeng Li Guoliang Chen Tao Lin Penghui Zhang Kuileung Tong Ningning Chen Shaoyu Liu 
supported by the National Natural Science Foundation of China,No.81801907(to NC);Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research,No.ZDSYS20230626091402006(to NC);Sanming Project of Medicine in Shenzhen,No.SZSM201911002(to SL);Foundation of Shenzhen Committee for Science and Technology Innovation,Nos.JCYJ20230807110310021(to NC),JCYJ20230807110259002(to JL);Science and Technology Program of Guangzhou,No.2024A04J4716(to TL)。
We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord injury.While exosomes are recognized as playing a pivotal role in neural stem cells exocrine func...
关键词：cellular communication competing endogenous RNA EXOSOMES Foxp1 NECROPTOSIS neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2 
Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives
《Neural Regeneration Research》2025年第11期3151-3171,共21页Fatima Aldali Chunchu Deng Mingbo Nie Hong Chen 
supported by the Key Research and Development Project of Hubei Province of China,2022BCA028(to HC)。
“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal cord.Peripheral nerve injury results in movements or sensation impairments,and represents a serious public health pro...
关键词：clinical trials EXOSOME extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments 
Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease
《Neural Regeneration Research》2025年第10期2998-3012,共15页Yuan Zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng Yang 
supported by the Science and Technology(S&T)Program of Hebei Province,No.22377798D(to YZ).
Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease progression.The proteins,DNA,mRNA,and lipids carried by exosomes reflect...
关键词：biomarker diagnosis EXOSOMES N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein 
Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease
《Neural Regeneration Research》2025年第9期2538-2555,共18页Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren 
supported by Open Project of the Key Laboratory of Trauma and Orthopedics Research Medicine in Henan Province,No.HZKFKT20220504(to YZ);the National Natural Science Foundation of China,No.32000877(to YZ);and Open Scientific Research Program of Military Logistics,No.BLB20J009(to YZ)。
Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive defi...
关键词：blood-brain barrier cognitive dysfunction EXOSOMES gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles NEUROINFLAMMATION polymer nanoparticles stem cells 
MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder
《Neural Regeneration Research》2025年第7期1957-1970,共14页Bridget Martinez Philip V.Peplow 
Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life events.Currently,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with...
关键词：BIOMARKER DIAGNOSIS microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma 
Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder
《Neural Regeneration Research》2025年第6期1541-1554,共14页Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng 
supported by the National Natural Science Foundation of China,No.81971269 (to DP);the Science and Technology Commission of Shanghai,No.YDZX20213100001003 (to DP)。
In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release f...
关键词：BIOMARKER cytokine EXOSOMES INFLAMMASOME major depressive disorder MICROGLIA mitochondrial DNA mitochondrial dysfunction NEUROINFLAMMATION Toll-like receptor 
MicroRNAs as potential diagnostic biomarkers for bipolar disorder
《Neural Regeneration Research》2025年第6期1681-1695,共15页Bridget Martinez Philip V.Peplow 
Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarke...
关键词：BIOMARKER bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines MICRORNA neural progenitor cells whole blood 
Exosomes:the next-generation therapeutic platform for ischemic stroke
《Neural Regeneration Research》2025年第5期1221-1235,共15页Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun Zhen-Ni Guo Yi Yang 
supported by the National Natural Science Foundation of China,Nos.82071291(to YY),82301464(to HM);the Norman Bethune Health Science Center of Jilin University,No.2022JBGS03(to YY);a grant from Department of Science and Technology of Jilin Province,Nos.YDZJ202302CXJD061(to YY),20220303002SF(to YY);a grant from Jilin Provincial Key Laboratory,No.YDZJ202302CXJD017(to YY);Talent Reserve Program of First Hospital of Jilin University,No.JDYYCB-2023002(to ZNG)。
Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional recovery.Therefore,there is an urgent need to develop new methods for the treatment of this condition.E...
关键词：blood–brain barrier ELECTROACUPUNCTURE engineering exercise EXOSOMES ischemic stroke mesenchymal stem cells MICROGLIA NEUROPROTECTION STENTS 
Exosomal mediators in sepsis and inflammatory organ injury:unraveling the role of exosomes in intercellular crosstalk and organ dysfunction
《Military Medical Research》2025年第2期264-284,共21页Ting Gong You-Tan Liu Jie Fan 
USA National Institutes of Health Grant(R01-HL-139547,to JF);USA VA Grants(1I01BX004838 and IK6BX004211,to JF);National Natural Science Foundation of China(82002087,to TG);Shenzhen Science and Technology Program(JCYJ20210324134602008,to TG)。
Sepsis,a severe systemic inflammatory response to infection,remains a leading cause of morbidity and mortality worldwide.Exosomes,as mediators of intercellular communication,play a pivotal role in the pathogenesis of ...
关键词：SEPSIS EXOSOMES Intercellular crosstalk Inflammation Biomarkers 
Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report
《Neural Regeneration Research》2025年第4期1207-1216,共10页Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest 
support from the Miami Project to Cure Paralysis,the Buoniconti Fund,and the Interdisciplinary Stem Cell Institute(to AK,WDD,JDG,and ADL);the unconditional support of Dean Henri Ford of the Leonard M.Miller School of Medicine at the University of Miami.
Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular junction.In amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann c...
关键词：ALLOGENEIC amyotrophic lateral sclerosis EXOSOMES INFUSION neuromuscular junction Schwann cell 
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