EXOSOMES

作品数：716被引量：2723H指数：22
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相关领域：医药卫生更多>>
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相关机构：重庆医科大学浙江大学东南大学重庆医科大学附属第一医院更多>>
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Exosomes in neurodegenerative diseases:Therapeutic potential and modification methods
《Neural Regeneration Research》2026年第2期478-490,共13页Hongli Chen Na Li Yuanhao Cai Chunyan Ma Yutong Ye Xinyu Shi Jun Guo Zhibo Han Yi Liu Xunbin Wei 
supported by the National Natural Science Foundation of China,No.22103055(to JG);the Natural Science Foundation of Hebei Province,No.F2024110001(to HC);and Open Project of Tianjin Key Laboratory of Optoelectronic Detection Technology and System,Nos.2024LODTS215(to NL),2024LODTS216(to XS).
In recent years,exosomes have garnered extensive attention as therapeutic agents and early diagnostic markers in neurodegenerative disease research.Exosomes are small and can effectively cross the blood-brain barrier,...
关键词：Alzheimer’s disease cell recognition central nervous system diseases enhanced targeting exosome modification exosome targeting neurodegenerative disease Parkinson’s disease stem cell exosomes stem cell therapy 
Exosomes in stroke management:A promising paradigm shift in stroke therapy
《Neural Regeneration Research》2026年第1期6-22,共17页Bo Wang Pinzhen Chen Wenyan Li Zhi Chen 
supported by the Natural Science Foundation of Chongqing,No.CSTB2023NSCQ-mSX0561(to WL).
Effective treatment methods for stroke,a common cerebrovascular disease with a high mortality rate,are still being sought.Exosome therapy,a form of acellular therapy,has demonstrated promising efficacy in various dise...
关键词：angiogenesis animal model cerebrovascular disorder extracellular vesicle mortality rates neural stem cell NEUROINFLAMMATION oxidative stress programmed cell death therapy 
Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury
《Neural Regeneration Research》2025年第11期3273-3286,共14页Shiming Li Jianfeng Li Guoliang Chen Tao Lin Penghui Zhang Kuileung Tong Ningning Chen Shaoyu Liu 
supported by the National Natural Science Foundation of China,No.81801907(to NC);Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research,No.ZDSYS20230626091402006(to NC);Sanming Project of Medicine in Shenzhen,No.SZSM201911002(to SL);Foundation of Shenzhen Committee for Science and Technology Innovation,Nos.JCYJ20230807110310021(to NC),JCYJ20230807110259002(to JL);Science and Technology Program of Guangzhou,No.2024A04J4716(to TL)。
We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord injury.While exosomes are recognized as playing a pivotal role in neural stem cells exocrine func...
关键词：cellular communication competing endogenous RNA EXOSOMES Foxp1 NECROPTOSIS neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2 
Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives被引量：1
《Neural Regeneration Research》2025年第11期3151-3171,共21页Fatima Aldali Chunchu Deng Mingbo Nie Hong Chen 
supported by the Key Research and Development Project of Hubei Province of China,2022BCA028(to HC)。
“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal cord.Peripheral nerve injury results in movements or sensation impairments,and represents a serious public health pro...
关键词：clinical trials EXOSOME extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments 
Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease
《Neural Regeneration Research》2025年第10期2998-3012,共15页Yuan Zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng Yang 
supported by the Science and Technology(S&T)Program of Hebei Province,No.22377798D(to YZ).
Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease progression.The proteins,DNA,mRNA,and lipids carried by exosomes reflect...
关键词：biomarker diagnosis EXOSOMES N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein 
Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease
《Neural Regeneration Research》2025年第9期2538-2555,共18页Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren 
supported by Open Project of the Key Laboratory of Trauma and Orthopedics Research Medicine in Henan Province,No.HZKFKT20220504(to YZ);the National Natural Science Foundation of China,No.32000877(to YZ);and Open Scientific Research Program of Military Logistics,No.BLB20J009(to YZ)。
Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive defi...
关键词：blood-brain barrier cognitive dysfunction EXOSOMES gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles NEUROINFLAMMATION polymer nanoparticles stem cells 
MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder
《Neural Regeneration Research》2025年第7期1957-1970,共14页Bridget Martinez Philip V.Peplow 
Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life events.Currently,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with...
关键词：BIOMARKER DIAGNOSIS microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma 
Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder
《Neural Regeneration Research》2025年第6期1541-1554,共14页Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng 
supported by the National Natural Science Foundation of China,No.81971269 (to DP);the Science and Technology Commission of Shanghai,No.YDZX20213100001003 (to DP)。
In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release f...
关键词：BIOMARKER cytokine EXOSOMES INFLAMMASOME major depressive disorder MICROGLIA mitochondrial DNA mitochondrial dysfunction NEUROINFLAMMATION Toll-like receptor 
MicroRNAs as potential diagnostic biomarkers for bipolar disorder
《Neural Regeneration Research》2025年第6期1681-1695,共15页Bridget Martinez Philip V.Peplow 
Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarke...
关键词：BIOMARKER bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines MICRORNA neural progenitor cells whole blood 
Exosomes:the next-generation therapeutic platform for ischemic stroke被引量：1
《Neural Regeneration Research》2025年第5期1221-1235,共15页Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun Zhen-Ni Guo Yi Yang 
supported by the National Natural Science Foundation of China,Nos.82071291(to YY),82301464(to HM);the Norman Bethune Health Science Center of Jilin University,No.2022JBGS03(to YY);a grant from Department of Science and Technology of Jilin Province,Nos.YDZJ202302CXJD061(to YY),20220303002SF(to YY);a grant from Jilin Provincial Key Laboratory,No.YDZJ202302CXJD017(to YY);Talent Reserve Program of First Hospital of Jilin University,No.JDYYCB-2023002(to ZNG)。
Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional recovery.Therefore,there is an urgent need to develop new methods for the treatment of this condition.E...
关键词：blood–brain barrier ELECTROACUPUNCTURE engineering exercise EXOSOMES ischemic stroke mesenchymal stem cells MICROGLIA NEUROPROTECTION STENTS 
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