EXOSOME

作品数：457被引量：1982H指数：21
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相关领域：医药卫生更多>>
相关作者：黄赤兵卜宁张尧吴小候罗春丽更多>>
相关机构：东南大学山东大学苏州大学第四军医大学西京医院更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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Exosomes in neurodegenerative diseases:Therapeutic potential and modification methods
《Neural Regeneration Research》2026年第2期478-490,共13页Hongli Chen Na Li Yuanhao Cai Chunyan Ma Yutong Ye Xinyu Shi Jun Guo Zhibo Han Yi Liu Xunbin Wei 
supported by the National Natural Science Foundation of China,No.22103055(to JG);the Natural Science Foundation of Hebei Province,No.F2024110001(to HC);and Open Project of Tianjin Key Laboratory of Optoelectronic Detection Technology and System,Nos.2024LODTS215(to NL),2024LODTS216(to XS).
In recent years,exosomes have garnered extensive attention as therapeutic agents and early diagnostic markers in neurodegenerative disease research.Exosomes are small and can effectively cross the blood-brain barrier,...
关键词：Alzheimer’s disease cell recognition central nervous system diseases enhanced targeting exosome modification exosome targeting neurodegenerative disease Parkinson’s disease stem cell exosomes stem cell therapy 
Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway
《Neural Regeneration Research》2025年第11期3245-3258,共14页Jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing Liu 
supported by the National Nature Science Foundation of China,No.81471308(to JL);the Innovative Leading Talents of Liaoning Province,No.XLYC1902031(to JL);Science and Technology Projects in Liaoning Province,No.2022-BS-238(to CH);Young Top Talents of Liaoning Province,No.XLYC1907009(to LW);Dalian Science and Technology Innovation Fund,No.2018J11CY025(to JL)。
Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem ce...
关键词：behavior EXOSOME extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT) 
Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives被引量：1
《Neural Regeneration Research》2025年第11期3151-3171,共21页Fatima Aldali Chunchu Deng Mingbo Nie Hong Chen 
supported by the Key Research and Development Project of Hubei Province of China,2022BCA028(to HC)。
“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal cord.Peripheral nerve injury results in movements or sensation impairments,and represents a serious public health pro...
关键词：clinical trials EXOSOME extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments 
The role of lncRNAs in AKI and CKD:Molecular mechanisms,biomarkers,and potential therapeutic targets
《Genes & Diseases》2025年第3期278-296,共19页Minhui Zheng Zixuan Yang Lei Shi Liyuan Zhao Kelan Liu Naping Tang 
Exosomes, a type of extracellular vesicle, are commonly found in different bodyfluids and are rich in nucleic acids (circRNA, lncRNAs, miRNAs, mRNAs, tRNAs, etc.), proteins,and lipids. They are involved in intercellul...
关键词：Acute kidney injury BIOMARKER Chronic kidney disease EXOSOME lncRNA Renal fibrosis 
Mechanisms and challenges of mesenchymal stem cells in the treatment of knee osteoarthritis
《World Journal of Stem Cells》2025年第4期1-5,共5页Jing-Shun Lu Chen-Yu Song Wen-Jing Cheng Kai-Yang Wang 
In this editorial,we comment on the recent article by Xiao et al,focusing on their investigation into whether the therapeutic efficacy of serum-free human umbilical cord mesenchymal stem cells(MSCs)differs from that o...
关键词：Mesenchymal stem cells Knee osteoarthritis INFLAMMATION EXOSOME Biological materials 
Evaluating the efficacy of stem cells in treating severe dry eye disease
《World Journal of Stem Cells》2025年第4期36-47,共12页Lanxing Fu Lucia Pelosini Nick Kopsachilis Roberta Foti Fabiana D’Esposito Mutali Musa Alberto D’Amico Daniele Tognetto Caterina Gagliano Marco Zeppieri 
Dry eye disease(DED)is a multifactorial disorder that disturbs ocular surface equilibrium,considerably diminishing quality of life.Present therapies only offer symptomatic alleviation.Stem cell treatment,especially me...
关键词：Dry eye disease Stem cell therapy Mesenchymal stem cells Corneal regeneration EXOSOME CORNEA Clinical trials 
Serum exosome-derived ALDH1A1 can greatly predict the prognosis of patients with hepatitis E virus-related acute liver failure
《Hepatobiliary & Pancreatic Diseases International》2025年第2期170-176,共7页An-Quan Shang Hong Yan Ze Xiang Jia-Qi Chen Bin Jiang Chun Jiang Bai Ling Jian Wu Chinese Consortium for the Study of Hepatitis E(CCSHE) 
supported by grants from the National Nat-ural Science Foundation of China(82272396);Suzhou Med-ical and Health Science and Technology Innovation Project(SKY2022057)。
Background:Despite the insights into the role of aldehyde dehydrogenase 1 family member A1(ALDH1A1)in various liver diseases,the expression and its prognostic significance in patients with hepatitis E virus-related ac...
关键词：Hepatitis e virus Acute liver failure Aldehyde dehydrogenase 1 family member a1(aldh1a1) EXOSOME 
Expression profiling and bioinformatics analysis of serum exosomal circular RNAs in lymph node metastasis of papillary thyroid carcinoma
《Journal of Biomedical Research》2025年第2期155-170,I0001-I0004,共20页Huiyong Peng Zhangwei Zhu Jie Xing Qian Xu Changfeng Man Shengjun Wang Yingzhao Liu Zhengdong Zhang 
National Natural Science Foundation of China (Grant No. 81800698);Jiangsu Provincial Medical Key Discipline Cultivation Unit (Grant No. JSDW202241);Research Project of Jiangsu Commission of Health (Grant No. H2023053);Zhenjiang Science and the Technology Planning Project (Grant Nos. SH2023006and SH2023008)。
Most papillary thyroid carcinoma(PTC) patients have a good prognosis. However, lymph node metastasis(LNM), the most common manifestation of disease progression, is frequently associated with a poor prognosis.Neverthel...
关键词：papillary thyroid carcinoma EXOSOME circular RNA regulatory network lymph node metastasis 
Zedoarondiol Inhibits Neovascularization in Atherosclerotic Plaques of ApoE^(-/-)Mice by Reducing Platelet Exosomes-Derived MiR-let-7a
《Chinese Journal of Integrative Medicine》2025年第3期228-239,共12页XIE Bei-li SONG Bo-ce LIU Ming-wang WEN Wei YAN Yu-xin GAO Meng-jie JIANG Lu-lian JIN Zhi-die YANG Lin LIU Jian-gang SHI Da-zhuo ZHAO Fu-hai 
Supported by the Science and Technology Innovation Project of Chinese Academy of Traditional Chinese Medicine(No.CI2021A00910);the National Natural Science Foundation of China(No.81973674)。
Objective:To investigate the effect of zedoarondiol on neovascularization of atherosclerotic(AS)plaque by exosomes experiment.Methods:ApoE^(-/-)mice were fed with high-fat diet to establish AS model and treated with h...
关键词：zedoarondiol atherosclerosis NEOVASCULARIZATION thrombospondin 1 EXOSOMES miR-let-7a 
Mesenchymal stem cell exosomes enhance the development of hair follicle to ameliorate androgenetic alopecia
《World Journal of Stem Cells》2025年第3期102-123,共22页Yu Fu Yao-Ting Han Jun-Ling Xie Rong-Qi Liu Bo Zhao Xing-Liao Zhang Jun Zhang Jing Zhang 
Supported by the Peak Disciplines(Type IV)of Institutions of Higher Learning in Shanghai and the China Postdoctoral Science Foundation,No.2022M722409.
BACKGROUND Mesenchymal stem cells(MSCs)and their secretome have significant potential in promoting hair follicle development.However,the effects of MSC therapy have been reported to vary due to their heterogeneous cha...
关键词：Mesenchymal stem cells EXOSOME Dermal papillary cells Hair development Liquid chromatography-mass spectrometry proteomic analysis 
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