Mechanisms and challenges of mesenchymal stem cells in the treatment of knee osteoarthritis  

作　　者：Jing-Shun Lu Chen-Yu Song Wen-Jing Cheng Kai-Yang Wang 

机构地区：[1]Department of Orthopedics,The First Affiliated Hospital of Wannan Medical College,Yijishan Hospital,Wuhu 241000,Anhui Province,China [2]Department of Orthopedic Surgery,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai 200233,China

出　　处：《World Journal of Stem Cells》2025年第4期1-5,共5页世界干细胞杂志(英文)

摘　　要：In this editorial,we comment on the recent article by Xiao et al,focusing on their investigation into whether the therapeutic efficacy of serum-free human umbilical cord mesenchymal stem cells(MSCs)differs from that of serum-containing human umbilical cord MSCs in a mouse model of knee osteoarthritis(OA).The incidence of OA has significantly increased in recent years,primarily owing to sports-related injuries or degenerative diseases.However,the regenerative capacity of articular cartilage remains limited,necessitating artificial joint replacement for patients with advanced OA to enhance the quality of life.MSCs have been widely used in the clinical treatment of OA owing to their multidirectional differentiation potential and immunomodulatory effects.The focus of this paper lies in elucidating the mechanism underlying MSC transplantation for the treatment of knee OA,while also addressing the challenges encountered in MSC therapy and outlining future directions.

关 键 词：Mesenchymal stem cells Knee osteoarthritis INFLAMMATION EXOSOME Biological materials 

分 类 号：R684.3[医药卫生—骨科学]