Serum exosome-derived ALDH1A1 can greatly predict the prognosis of patients with hepatitis E virus-related acute liver failure  

作　　者：An-Quan Shang Hong Yan Ze Xiang Jia-Qi Chen Bin Jiang Chun Jiang Bai Ling Jian Wu Chinese Consortium for the Study of Hepatitis E(CCSHE) 

机构地区：[1]Department of Laboratory Medicine,The Second People’s Hospital of Lianyungang&The Oncology Hospital of Lianyungang,Lianyungang 222006,China [2]Laboratory Medicine Center,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China [3]Zhejiang University School of Medicine,Hangzhou 310009,China [4]Jiangsu University School of Medicine,Zhenjiang 212013,China [5]Department of Laboratory Medicine,The Central Blood Station of Yancheng City,Yancheng 224000,China [6]Department of Clinical Laboratory,The Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Gusu School,Nanjing Medical University,Suzhou 215008,China [7]Department of Pharmacy,The First People’s Hospital of Yancheng,The Yancheng Clinical College of Xuzhou Medical University,Yancheng 224006,China [8]不详

出　　处：《Hepatobiliary & Pancreatic Diseases International》2025年第2期170-176,共7页国际肝胆胰疾病杂志(英文版)

基　　金：supported by grants from the National Nat-ural Science Foundation of China(82272396);Suzhou Med-ical and Health Science and Technology Innovation Project(SKY2022057)。

摘　　要：Background:Despite the insights into the role of aldehyde dehydrogenase 1 family member A1(ALDH1A1)in various liver diseases,the expression and its prognostic significance in patients with hepatitis E virus-related acute liver failure(HEV-ALF)remain unclear.This study delved into the assessment of serum exosome-derived ALDH1A1 expression and its prognostic implications for HEV-ALF patients.Methods:Between January 2018 and December 2023,a total of 226 individuals with acute hepatitis E(AHE)and 210 patients with HEV-ALF were recruited from member units of Chinese Consortium for the Study of Hepatitis E.According to the number of organ failure,we categorized 210 HEV-ALF patients into three groups:two organs failure(n=131),three organs failure(n=46),and more than three organs failure(n=33).In addition,200 health controls from Suzhou Municipal Hospital were included.Results:The levels of serum exosome-derived ALDH1A1 in HEV-ALF patients were significantly higher than those in AHE patients and health controls(both P<0.05).Furthermore,the levels of serum exosome-derived ALDH1A1 were the highest in more than three organs failure group,followed by three organs failure group and two organs failure group(all P<0.001).Moreover,serum exosome-derived ALDH1A1 was positively correlated with total bilirubin in HEV-ALF patients(r=0.315,P<0.001).The comparisons of serum exosome-derived ALDH1A1 levels in treatment response showed that serum exosome-derived ALDH1A1 levels were decreased in the improvement group,while increased in the fluctuation and deterioration groups(all P<0.001).Moreover,serum exosome-derived ALDH1A1 was an independent risk factor for predicting the 30-day mortality(P<0.001).Furthermore,the area under the receiver operating characteristic curve was 0.943,with the sensitivity of 94.87%and specificity of 87.72%,indicating the robust decision-making ability.However,no significant differences were found in serum exosome-derived ALDH1A1 levels between patients aged<60 and≥60 years old(P=0.131).Conclusions:Serum exos

关 键 词：Hepatitis e virus Acute liver failure Aldehyde dehydrogenase 1 family member a1(aldh1a1) EXOSOME 

分 类 号：R575.3[医药卫生—消化系统]