The role of lncRNAs in AKI and CKD:Molecular mechanisms,biomarkers,and potential therapeutic targets  

作　　者：Minhui Zheng Zixuan Yang Lei Shi Liyuan Zhao Kelan Liu Naping Tang 

机构地区：[1]Shanghai Innostar Bio-Technology Co.,Ltd.,China State Institute of Pharmaceutical Industry,Shanghai 201203,China [2]Anhui University of Traditional Chinese Medicine,Hefei,Anhui 230000,China [3]Yangtze Delta Drug Advanced Research Institute,Yangtze Delta Pharmaceutical College,Nantong,Jiangsu 226133,China [4]Intensive Care Unit,Liyang People’s Hospital,Liyang,Jiangsu 213300,China

出　　处：《Genes & Diseases》2025年第3期278-296,共19页基因与疾病(英文)

摘　　要：Exosomes, a type of extracellular vesicle, are commonly found in different bodyfluids and are rich in nucleic acids (circRNA, lncRNAs, miRNAs, mRNAs, tRNAs, etc.), proteins,and lipids. They are involved in intercellular communication. lncRNAs are responsible for themodulation of gene expression, thus affecting the pathological process of kidney injury. Thisreview summarizes the latest knowledge on the roles of exosome lncRNAs and circulatinglncRNAs in the pathogenesis, biomarker discovery, and treatment of chronic kidney disease,renal fibrosis, and acute kidney injury, providing an overview of novel regulatory approachesand lncRNA delivery systems.

关 键 词：Acute kidney injury BIOMARKER Chronic kidney disease EXOSOME lncRNA Renal fibrosis 

分 类 号：R692[医药卫生—泌尿科学]