INFLAMMASOME

作品数：391被引量：2615H指数：23
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相关领域：医药卫生更多>>
相关作者：韩蓉吴东明吴玉章许颖陈永文更多>>
相关机构：第二军医大学广州医科大学华中科技大学安徽医科大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划上海市自然科学基金更多>>
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NLRP3 inflammasome and gut microbiota–brain axis:A new perspective on white matter injury after intracerebral hemorrhage
《Neural Regeneration Research》2026年第1期62-80,共19页Xiaoxi Cai Xinhong Cai Quanhua Xie Xueqi Xiao Tong Li Tian Zhou Haitao Sun 
supported by the Guangdong Basic and Applied Basic Research Foundation,No.2023A1515030045(to HS);Presidential Foundation of Zhujiang Hospital of Southern Medical University,No.yzjj2022ms4(to HS)。
Intracerebral hemorrhage is the most dangerous subtype of stroke,characterized by high mortality and morbidity rates,and frequently leads to significant secondary white matter injury.In recent decades,studies have rev...
关键词：gut microbiota gut microbiota–brain axis immune intracerebral hemorrhage NEUROINFLAMMATION NLRP3 protein stroke THERAPEUTICS white matter injury 
Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss被引量：1
《Neural Regeneration Research》2025年第10期3025-3039,共15页Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin 
supported by the National Natural Science Foundation of China,Nos.81800919(to YX),82171140(to PW);the International Cooperation and Exchange of the National Natural Science Foundation of China,Nos.82020108008(to HS),81720108010(to SY).
Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum.However,their use leads to irreversible hearing damage by causing apoptosis of hair cells as ...
关键词：DEGENERATION hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome OTOTOXICITY pyroptosis sensorineural hearing loss spiral ganglion neuron 
FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression
《Neural Regeneration Research》2025年第7期2068-2083,共16页Jing Yao Yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song 
supported by a grant from Key Laboratory of Alzheimer's Disease of Zhejiang Province,Institute of Aging,Wenzhou Medical University,No.ZJAD-2021002(to ZW)。
Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in...
关键词：5′end trimming Alzheimer's disease AMYLOID-BETA amyloid-β-dependent transcription FUBP3 INFLAMMASOME inflammation neuron NLRP3 tau transcription factor 
Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder
《Neural Regeneration Research》2025年第6期1541-1554,共14页Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng 
supported by the National Natural Science Foundation of China,No.81971269 (to DP);the Science and Technology Commission of Shanghai,No.YDZX20213100001003 (to DP)。
In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release f...
关键词：BIOMARKER cytokine EXOSOMES INFLAMMASOME major depressive disorder MICROGLIA mitochondrial DNA mitochondrial dysfunction NEUROINFLAMMATION Toll-like receptor 
Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease被引量：1
《Neural Regeneration Research》2025年第6期1644-1664,共21页Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy 
Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of n...
关键词：Alzheimer's disease caspase-1 chronic traumatic encephalopathy INFLAMMASOMES NEURODEGENERATION neuroinflammation NLRP1 NLRP3 PYROPTOSIS TAUOPATHY traumatic brain injury 
Fenofibrate mitigates the dysfunction of high glucosedriven human retinal microvascular endothelial cells by suppressing NLRP3 inflammasome
《International Journal of Ophthalmology(English edition)》2025年第5期792-801,共10页Yi Shi Hao-Min Chen Ai-Hua Liu Xiao-Rong Li 
Supported by grants from the Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJYXZDXK-037A).
AIM:To determine the therapeutic benefits of fenofibrate(Feno)on the dysfunction of high glucose(HG)-induced human retinal microvascular endothelial cells(HRMECs)and to elucidate the underlying molecular mechanism.MET...
关键词：FENOFIBRATE human retinal microvascular endothelial cells high glucose NOD-like receptor thermal protein domain associated protein 3 inflammasomes oxidative stress 
Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation
《Acta Pharmacologica Sinica》2025年第4期1016-1029,共14页Le-jin Yan Shuang Qi Chao Wu Rui Jin Chen Hu Ao-li Wang Bei-lei Wang Hong-wei Yu Li Wang Jing Liu Zi-ping Qi Wen-chao Wang Qing-song Liu 
supported by the National Natural Science Foundation of China(Grant Nos.82373715,32171479,82304784);the Major Science and Technology Project of Anhui Province(Grant No.202303a07020007);the CASHIPS Director’s Found(Grant No.BJPY2022A02).
Abnormal activation of NLRP3 inflammasome causes the progression of gout,and no small-molecule inhibitor of NLRP3 has been approved yet for clinical use.In this study we established a nigericin-induced inflammasome ac...
关键词：gouty arthritis hypocrellin A ethnic medicine NLRP3 inflammasome NEK7 NACHT domain 
Transmembrane protein 176B promotes epithelial-mesenchymal transition in colorectal cancer through inflammasome inhibition
《World Journal of Gastrointestinal Oncology》2025年第3期171-187,共17页Wei Qian Chong-Yi Xu Wei Hong Zhe-Ming Li Dao-Gun Xu 
Ministry of Education Industry-University Co-operation Collaborative Education Project,No.202102242020.
BACKGROUND Activation of the epithelial-mesenchymal transition(EMT),a pivotal process in tumor metastasis and evasion,as well as the NLRP3 inflammasome,both promote colorectal cancer(CRC)progression.Recent studies hav...
关键词：Transmembrane protein 176B Epithelial-mesenchymal transition Colorectal cancer Pyrin domain containing 3 inflammasome Natural killer cell 
Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation
《World Journal of Gastroenterology》2025年第9期100-134,共35页Xue-Jiao Liu Ye-li-ya Ye-er-tai Yue-Bo Jia Chen-Heng Wu Xiang-Xiang Wang Ke-Ming Yang Xuan Yao Jiang-Hong Ling 
Supported by National Natural Science Foundation of China,No.82174309;and Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Siming Fund Special Project for Scientific Research,No.SGKJ-202304.
BACKGROUND Runchangningshen paste(RCNSP)is a paste made of four medicinal and edible homologous Chinese medicine mixed with honey.It is known for its ability to nourish yin and blood as well as to loosen the bowel to ...
关键词：Traditional Chinese medicine Functional constipation NLRP6 AUTOPHAGY Mucosal microbiota MUCIN Goblet cells 
Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke被引量：2
《Neural Regeneration Research》2025年第2期491-502,共12页Shuai Feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen Shen Liu Junshan Zhou Hongdong Zhao Ye Hong 
supported by the National Natural Science Foundation of China,No.82201460(to YH);Nanjing Medical University Science and Technology Development Fund,No.NMUB20210202(to YH).
Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion injury.Low-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit...
关键词：inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome POLARIZATION 
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