云南高校图书馆联盟文献共享服务平台- TAUOPATHY

TAUOPATHY: 作品数：26被引量：56H指数：4; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：冯利杰更多>>; 相关机构：安徽医科大学中南财经政法大学更多>>; 相关期刊：《Acta Pharmacologica Sinica》《日本医学介绍》《Neural Regeneration Research》《Translational Neurodegeneration》更多>>; 相关基金：国家自然科学基金湖北省自然科学基金更多>>

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice: 《Neural Regeneration Research》2025年第8期2348-2360,共13页Mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel; supported by the Koeln Fortune Program/Faculty of Medicine,University of Cologne,the Alzheimer Forschung Initiative e.V.(grant#22039,to HZ);open-access funding from the DFG/GRC issued to the University of Cologne;Alzheimer Forschung Initiative e.V.for Open Access Publishing(a publication grant#P2401,to MAAK)。; TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon.TAU is missorted and aggregated in an array of diseases known as tauopathies.Microtubules are essential for neuronal...; 关键词：human induced pluripotent stem cell MICROTUBULES P301L pR5 mice TAU TAUOPATHY tubulin code

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease被引量：1: 《Neural Regeneration Research》2025年第6期1644-1664,共21页Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy; Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of n...; 关键词：Alzheimer's disease caspase-1 chronic traumatic encephalopathy INFLAMMASOMES NEURODEGENERATION neuroinflammation NLRP1 NLRP3 PYROPTOSIS TAUOPATHY traumatic brain injury

A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer’s disease therapy: 《Bioactive Materials》2024年第12期165-177,共13页Qin Zhang Chuanqi Li Bohan Yin Jiaxiang Yan Yutian Gu Yingying Huang Jiareng Chen Xinyue Lao Jianhua Hao Changqing Yi Yi Zhou James Chung Wai Cheung Siu Hong Dexter Wong Mo Yang; supported by the Shenzhen Science and Technology Program-Basic Research Scheme(JCYJ20220531090808020);the Research Grants Council(RGC)of Hong Kong Collaborative Research Grant(C5005-23W and C5078-21E);the Research Grants Council(RGC)of Hong Kong General Research Grant(PolyU 15217621 and PolyU 15216622);the Guangdong-Hong Kong Technology Cooperation Funding Scheme(GHP/032/20SZ and SGDX20201103095404018);the Hong Kong Polytechnic University Shenzhen Institute Bai Cheng Bai Yuan Fund(I2022A002);PolyU Internal Fund(1-YWB4,1-WZ4E,1-CD8M,1-WZ4E,1-CEB1,1-YWDU,1-CE2J and 1-W02C);the funding from the Laboratory for Marine Drugs and Bioproducts,Qingdao Marine Science and Technology Center(No.:LMDBCXRC202401 and LMDBCXRC202402);Shandong Provincial Overseas Excellent Young Scholar Program(2024HWYQ-042 and 2024HWYQ-043);Taishan Scholar Youth Expert Program of Shandong Province(tsqn202306102 and tsqn202312105)supporting this work;supported by the University Research Facility in Life Sciences of the Hong Kong Polytechnic University.; Abnormal hyperphosphorylation of tau protein is a principal pathological hallmark in the onset of neurodegenerative disorders,such as Alzheimer’s disease(AD),which can be induced by an excess of reactive oxygen speci...; 关键词：Artificial photosynthesis Hydrogen therapy Oxidative stress Tau hyperphosphorylation Alzheimer’s disease

A new tau dephosphorylation-targeting chimera for the treatment of tauopathies: 《Acta Pharmacologica Sinica》2024年第11期2267-2276,共10页Jing-fen Su Yue Xiao Lin-yu Wei Hui-yang Lei Fei Sun Wei-xia Wang Shi-hong Li Xiao-chuan Wang Jie Zheng Jian-zhi Wang; supported by the National Natural Science Foundation of China(No.82230041,91949205);Sanming Project of Medicine in Shenzhen(No.SZSM202211010);Guangdong Provincial Key S&T Program(No.2018B030336001),Peking University Talent Startup Fund(No.BMU2022YJ003);supported by the“Fundamental Research Funds for the Central Universities”,Scientific Project of Beijing Life Science Academy(No.2024300CC0020).; Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies,including Alzheimer’s disease(AD).We have recently conceptualized the desi...; 关键词：TAU dephosphorylation targeting chimera(DEPTAC) TAUOPATHY Alzheimer’s disease drug development

多肽靶向嵌合体通过促进tau蛋白特异性去磷酸化治疗阿尔茨海默病和其他tau蛋白病被引量：1: 《Science Bulletin》2024年第8期1137-1152,共16页苏静芬肖越魏林郁雷慧杨孙飞王围霞尹君熊瑞李师宏张配周颖王小川郑杰王建枝; supported by the National Natural Science Foundation of China(82230041,91949205,31730035,81721005);the National Key R&D Program of China(2016YFC1305800);the Guangdong Provincial Key S&T Program(018B030336001)。; Abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration in Alzheimer’s disease(AD)and many other tauopathies.Selective elimination of hyperphosphorylated tau is promisin...; 关键词：TAU Dephosphorylation-targeting chimeras Therapeutic potential TAUOPATHY

Neuronal double-stranded DNA accumulation induced by DNase II deficiency drives tau phosphorylation and neurodegeneration: 《Translational Neurodegeneration》2024年第1期530-546,共17页Ling-Jie Li Xiao-Ying Sun Ya-Ru Huang Shuai Lu Yu-Ming Xu Jing Yang Xi-Xiu Xie Jie Zhu Xiao-Yun Niu Dan Wang Shi-Yu Liang Xiao-Yu Du Sheng-Jie Hou Xiao-Lin Yu Rui-Tian Liu; supported by funding from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39050600);the National Natural Science Foundation of China(82150107 and 81971073);the National Key Research and Development Program of China(2020YFA0712402).; Background Deoxyribonuclease 2(DNaseⅡ)plays a key role in clearing cytoplasmic double-stranded DNA(dsDNA).Deficiency of DNaseⅡleads to DNA accumulation in the cytoplasm.Persistent dsDNA in neurons is an early pathol...; 关键词：DNaseⅡ Alzheimer’s disease Double-stranded DNA Tau phosphorylation TAUOPATHY

CRISPR base editing-mediated correction of a tau mutation rescues cognitive decline in a mouse model of tauopathy: 《Translational Neurodegeneration》2024年第1期828-832,共5页Min Sung Gee Eunji Kwon Myeong-Hoon Song Seung Ho Jeon Namkwon Kim Jong Kil Lee Taeyoung Koo; supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(2022R1A2C1013352 and RS-2023–00262386 to T.K.);Ministry of Food and Drug Safety(21153MFDS601 to T.K.);the Medical Research Center Program through the National Research Foundation of Korea funded by the Ministry of Science and ICT(NRF-2017R1A5A2014768 to J.K.L.).; Main text The microtubule-binding protein tau is encoded by MAPT,located on chromosome 17.Mutations in this gene have been implicated in frontotemporal dementia[1].Down-regulation of endogenous tau with antisense olig...; 关键词：TAU MEDIATED ENDOGENOUS

Overlaps and divergences between tauopathies and synucleinopathies:a duet of neurodegeneration: 《Translational Neurodegeneration》2024年第1期861-873,共13页Wen Li Jia-Yi Li; supported by the National Natural Science Foundation of China(82371273,81430025,U1801681 to J-Y.L.and W.L.);the Key Field Research Development Program of Guangdong Province(2018B030337001);the Swedish Research Council(2019-01551,2023-02216);ParkinsonFonden(1351/21,1421/22,1494/23);the Strategic Research Area Multipark(Multidisciplinary research in Parkinson’s disease at Lund University);Hjarnfonden(FO2022-0282,FO2023-0397,PS2018-0062);Svenska Sällskapet för Medicinsk Forskning(SSMF,P18-0194).; Proteinopathy,defined as the abnormal accumulation of proteins that eventually leads to cell death,is one of the most significant pathological features of neurodegenerative diseases.Tauopathies,represented by Alzheime...; 关键词：TAUOPATHY SYNUCLEINOPATHY Tau α-Synuclein NEURODEGENERATION

Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys被引量：2: 《Signal Transduction and Targeted Therapy》2023年第10期5023-5035,共13页Zhuchi Tu Sen Yan Bofeng Han Cajuan Li Weien Liang Yingqi Lin Yongyan Ding Huiyi Wei Lu Wang Hao Xu Jianmeng Ye Bang Li Shihua Li Xiao-Jiang Li; This work was supported by the Guangzhou Key Research Program on Brain Science(202007030008,202007030003);The National Natural Science Foundation of China(32170981,81830032,31872779,81922026,82071421,82171244);National Key Research and Development Program of China(2021YFA0805300,2021YFA0805200);Department of Science and Technology of Guangdong Province(2021ZT09Y007,2020B121201006);Key Field Research and Development Program of Guangdong province(2018B030337001).; Tauopathy,characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau,and the accumulation of Aβ oligomers,constitute the major pathological hallmarks of Alzheimer's disease.H...; 关键词：PATHOLOGICAL CONSTITUTE MARKS

Towards understandings of serine/arginine-rich splicing factors被引量：7: 《Acta Pharmaceutica Sinica B》2023年第8期3181-3207,共27页Dianyang Li Wenying Yu Maode Lai; supported by grants from the National Natural Science Foundation of China(Grant No.82150203)。; Serine/arginine-rich splicing factors(SRSFs)refer to twelve RNA-binding proteins which regulate splice site recognition and spliceosome assembly during precursor messenger RNA splicing.SRSFs also participate in other ...; 关键词：Alternative splicing RNA metabolism Cancer therapy TAUOPATHY Autoimmunediseases Small molecule inhibitor

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