云南高校图书馆联盟文献共享服务平台- TAU

TAU: 作品数：882被引量：2378H指数：18; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：王建枝张志珺梁毅张兰陈杰更多>>; 相关机构：华中科技大学南通大学首都医科大学宣武医院武汉大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划江苏省自然科学基金北京市自然科学基金更多>>

Towards mechanism-based tau-targeted therapies: 《Neural Regeneration Research》2026年第2期687-688,共2页Lidia Bakota Roland Brandt; Tau plays a crucial role in several neurodegenerative diseases,collectively referred to as tauopathies.Therefore,targeting potential pathological changes in tau could enable useful therapeutic interventions.However,ta...; 关键词：tau targeted therapies cellular components mechanism based therapies cellular componentswhich cellular models MICROTUBULES TAUOPATHIES neurodegenerative diseasescollectively

Adiponectin as a potential mediator of the pro-cognitive effects of physical exercise on Alzheimer's disease: 《Neural Regeneration Research》2026年第1期96-106,共11页Hui-Hui Guo Hai-Ning Ou Jia-Sui Yu Julia Macedo Rosa Douglas Affonso Formolo Tong Cheng Suk-Yu Yau Hector Wing Hong Tsang; supported by the National Natural Science Foundation of China,No.82072529(to HWHT);Key Laboratory of Guangdong Higher Education Institutes,No.2021KSYS009(to HWHT);the China Postdoctoral Science Foundation,No.2022M720907(to HHG)。; Alzheimer's disease is the primary cause of dementia and imposes a significant socioeconomic burden globally.Physical exercise,as an effective strategy for improving general health,has been largely reported for its ef...; 关键词：adiponectin receptor agonists ADIPONECTIN Alzheimer's disease amyloid-β HIPPOCAMPUS learning and memory physical exercise TAU

Alzheimer's disease and the immune system:the emerging role of TEMRA cells: 《Neural Regeneration Research》2025年第12期3529-3530,共2页Edric D.Winford Adam D.Bachstetter; Alzheimer's disease (AD) is the most common form of dementia,affecting millions worldwide.It is cha racterized by progressive cognitive decline and changes in behavior and personality,attributed to neuropathological c...; 关键词：ALZHEIMER AΒ TAU

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice: 《Neural Regeneration Research》2025年第8期2348-2360,共13页Mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel; supported by the Koeln Fortune Program/Faculty of Medicine,University of Cologne,the Alzheimer Forschung Initiative e.V.(grant#22039,to HZ);open-access funding from the DFG/GRC issued to the University of Cologne;Alzheimer Forschung Initiative e.V.for Open Access Publishing(a publication grant#P2401,to MAAK)。; TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon.TAU is missorted and aggregated in an array of diseases known as tauopathies.Microtubules are essential for neuronal...; 关键词：human induced pluripotent stem cell MICROTUBULES P301L pR5 mice TAU TAUOPATHY tubulin code

Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology: 《Neural Regeneration Research》2025年第5期1407-1408,共2页Daniel Adam Felix Langerscheidt Hans Zempel; TAU is a neuronal microtubule-associated protein preferentially located in axons.In a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosph...; 关键词：ALZHEIMER TAU diseases

音乐疗法联合多奈哌齐治疗阿尔茨海默病疗效及对血清Aβ_(1~42)、P-Tau181水平的影响: 《中国老年学杂志》2025年第7期1622-1625,共4页陈琛赵泽魏海萍丁小斌; 甘肃省优秀研究生“创新之星”项目(2022KYZZ-B031)。; 目的探讨阿尔茨海默病(AD)使用音乐疗法联合多奈哌齐治疗的效果。方法老年AD患者92例随机分为对照组与观察组各46例,两组分别予以单纯多奈哌齐治疗、音乐疗法联合多奈哌齐治疗,连续治疗3个月。治疗前后采用简易精神状态评估(MMSE)量表...; 关键词：阿尔茨海默病音乐疗法多奈哌齐认知功能 Β淀粉样蛋白过磷酸化Tau-181蛋白

APP N端在阿尔茨海默病病理中的多维调控作用及靶向治疗潜力: 《贵州医科大学学报》2025年第3期313-324,共12页谭俊陈江齐晓岚; 国家自然科学基金(82060211,82460263);贵州医科大学高层次人才项目(YJ19017);贵州省科技厅计划项目(黔科合基础-ZK[2023]一般301);贵州省科技人才合作平台项目(CXTD[2023]003)。; 阿尔茨海默病(Alzheimer's disease,AD)的病理过程涉及多个机制,包括β-淀粉样蛋白(amyloid-β,Aβ)积聚、Tau蛋白磷酸化、神经炎症以及突触丧失。淀粉样前体蛋白(amyloid precursor protein,APP)作为Aβ的前体,APP N端不仅调控Aβ的生...; 关键词：阿尔茨海默病 APP N端 Aβ生成 Tau病理靶向治疗

基于Tau异常磷酸化探讨针刺干预阿尔茨海默病的机制研究进展: 《针灸临床杂志》2025年第3期95-99,共5页王添一何聪郑茹文滕昱博孙兴华张淼; 国家自然科学基金,编号:82174509;黑龙江省自然科学基金,编号:LH2023H066。; Tau异常磷酸化所形成的神经元纤维缠结是导致阿尔茨海默病(AD)发生及发展的重要病理变化。针刺作为一种传统的中医外治法,能从Tau激酶和Tau磷酸酶、神经胶质细胞与自噬3个层面抑制Tau异常磷酸化并改善AD病情。研究表明,针刺可通过干预Ta...; 关键词：阿尔茨海默病 TAU 针刺综述

Intervention and treatment of Alzheimer's disease: 《Life Research》2025年第1期44-50,共7页Dan-Lin Yue-Ran Ma Tian-Yang Jun-Ru Yang Jia-Rui Ma Wen-Rui Wu Si-Qi He Yu-Hong Lü Chang-Wu Yue; National Natural Science Foundation of China Regional Fund Project(Protective effect and mechanism of new antibiotic zunyimycins on Alzheimer's disease model,82060654).; Background:Alzheimer's disease(AD)is a degenerative disease that occurs in the central nervous system and is characterized by progressive cognitive dysfunction and behavioral impairment.The main pathological mechanism...; 关键词：AD AGING APOE AΒ TAU DRUGS INTERVENTION

Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies: 《Neural Regeneration Research》2025年第3期803-804,共2页Glenn A.Harris Lauren R.Hirschfeld; supported by the Rainwater Charitable Foundation。; Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as eit...; 关键词：TAU METABOLISM DISEASES

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