云南高校图书馆联盟文献共享服务平台- TAUOPATHIES

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Towards mechanism-based tau-targeted therapies: 《Neural Regeneration Research》2026年第2期687-688,共2页Lidia Bakota Roland Brandt; Tau plays a crucial role in several neurodegenerative diseases,collectively referred to as tauopathies.Therefore,targeting potential pathological changes in tau could enable useful therapeutic interventions.However,ta...; 关键词：tau targeted therapies cellular components mechanism based therapies cellular componentswhich cellular models MICROTUBULES TAUOPATHIES neurodegenerative diseasescollectively

Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies: 《Neural Regeneration Research》2025年第3期803-804,共2页Glenn A.Harris Lauren R.Hirschfeld; supported by the Rainwater Charitable Foundation。; Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as eit...; 关键词：TAU METABOLISM DISEASES

Self-assembly of tau fragments as a key pathologic event in tauopathies: 《Neural Regeneration Research》2024年第12期2565-2566,共2页Ly Thi Huong Luu Le Jung Hoon Lee Min Jae Lee; supported by grants from the National Research Foundation of Korea (2021 R1A2C2008023,2020R1A5A 1019023;RS-2023-00261784 to MJL;2021R1/1A1A 01051245to JHL)。; Tau protein is encoded by the microtubuleassociated protein tau(MAPT)gene and stabilizes microtubules in the neurons.Tau has unique biophysical properties that make it both highly water-soluble and positively charged....; 关键词：TAU PATHOLOGIC assembly

A new tau dephosphorylation-targeting chimera for the treatment of tauopathies: 《Acta Pharmacologica Sinica》2024年第11期2267-2276,共10页Jing-fen Su Yue Xiao Lin-yu Wei Hui-yang Lei Fei Sun Wei-xia Wang Shi-hong Li Xiao-chuan Wang Jie Zheng Jian-zhi Wang; supported by the National Natural Science Foundation of China(No.82230041,91949205);Sanming Project of Medicine in Shenzhen(No.SZSM202211010);Guangdong Provincial Key S&T Program(No.2018B030336001),Peking University Talent Startup Fund(No.BMU2022YJ003);supported by the“Fundamental Research Funds for the Central Universities”,Scientific Project of Beijing Life Science Academy(No.2024300CC0020).; Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies,including Alzheimer’s disease(AD).We have recently conceptualized the desi...; 关键词：TAU dephosphorylation targeting chimera(DEPTAC) TAUOPATHY Alzheimer’s disease drug development

Author Correction:A new tau dephosphorylation-targeting chimera for the treatment of tauopathies: 《Acta Pharmacologica Sinica》2024年第11期2453-2454,共2页Jing-fen Su Yue Xiao Lin-yu Wei Hui-yang Lei Fei Sun Wei-xia Wang Shi-hong Li Xiao-chuan Wang Jie Zheng Jian-zhi Wang; Correction to:Acta Pharmacologica Sinica(2024)0:1-10;https://doi.org/10.1038/s41401-024-01326-4,published online 02 July 2024 The authors would like to apologize for the errors in the previously published images of Fi...; 关键词：checked FIGURES FUSED

New insights into the therapeutic approaches for the treatment of tauopathies被引量：2: 《Neural Regeneration Research》2024年第5期1020-1026,共7页Himanshi Singh Asmita Das Mohammad Moshahid Khan Tayebeh Pourmotabbed; supported by National Institute of Health grant number R03AG075597(to MMK and TP);Department of Defense Award Number HT9425-23-1-0043(to MMK).; Tauopathies are a group of neurological disorders,including Alzheimer’s disease and frontotemporal dementia,which involve progressive neurodegeneration,cognitive deficits,and aberrant tau protein accumulation.The dev...; 关键词：DEMENTIA gene therapies IMMUNOTHERAPY NEURODEGENERATION OLIGONUCLEOTIDES tau TAUOPATHIES THERAPIES

Tau in neurodegenerative diseases:molecular mechanisms,biomarkers,and therapeutic strategies: 《Translational Neurodegeneration》2024年第1期513-529,共17页Xingyu Zhang Jiangyu Wang Zhentao Zhang Keqiang Ye; supported by grants from the National Key Basic Research Program of China(2019YFE0115900 to Z.Z.);the National Natural Science Foundation of China(81822016,81771382 to Z.Z.,82301356 to X.Z.,32330040,82350710222 to K.Y.).; The deposition of abnormal tau protein is characteristic of Alzheimer’s disease(AD)and a class of neurodegenerative diseases called tauopathies.Physiologically,tau maintains an intrinsically disordered structure and ...; 关键词：TAU Alzheimer’s disease TAUOPATHIES AGGREGATION PROPAGATION Biomarkers

Overlaps and divergences between tauopathies and synucleinopathies:a duet of neurodegeneration: 《Translational Neurodegeneration》2024年第1期861-873,共13页Wen Li Jia-Yi Li; supported by the National Natural Science Foundation of China(82371273,81430025,U1801681 to J-Y.L.and W.L.);the Key Field Research Development Program of Guangdong Province(2018B030337001);the Swedish Research Council(2019-01551,2023-02216);ParkinsonFonden(1351/21,1421/22,1494/23);the Strategic Research Area Multipark(Multidisciplinary research in Parkinson’s disease at Lund University);Hjarnfonden(FO2022-0282,FO2023-0397,PS2018-0062);Svenska Sällskapet för Medicinsk Forskning(SSMF,P18-0194).; Proteinopathy,defined as the abnormal accumulation of proteins that eventually leads to cell death,is one of the most significant pathological features of neurodegenerative diseases.Tauopathies,represented by Alzheime...; 关键词：TAUOPATHY SYNUCLEINOPATHY Tau α-Synuclein NEURODEGENERATION

Strategies for translating proteomics discoveries into drug discovery for dementia被引量：2: 《Neural Regeneration Research》2024年第1期132-139,共8页Aditi Halder Eleanor Drummond; supported by funding from the Bluesand Foundation,Alzheimer's Association(AARG-21-852072 and Bias Frangione Early Career Achievement Award)to ED;an Australian Government Research Training Program scholarship and the University of Sydney's Brain and Mind Centre fellowship to AH。; Tauopathies,diseases characterized by neuropathological aggregates of tau including Alzheimer's disease and subtypes of fro ntotemporal dementia,make up the vast majority of dementia cases.Although there have been rec...; 关键词：Alzheimer's disease biomarkers drug development drug discovery druggability frontotemporal dementia INTERACTOME PROTEOMICS tau TAUOPATHIES THERAPEUTICS

Recent development in selective Tau tracers for PET imaging in the brain被引量：1: 《Chinese Chemical Letters》2022年第7期3339-3348,共10页Yuying Li Tianqing Liu Mengchao Cui; funded by the National Natural Science Foundation of China(Nos.U1967221,22022601)。; Abnormal Tau deposition is a crucial pathological hallmark of various neurodegenerative disorders defined as tauopathies,of which Alzheimer’s disease is the most prominent one.To date,a large number of chemical entit...; 关键词：TAU PET imaging TAUOPATHIES Alzheimer’s disease SELECTIVITY

TAUOPATHIES