OLIGONUCLEOTIDES

作品数：75被引量：205H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：王晶刘张岚高运华张玲张礼和更多>>
相关机构：北京大学中国计量科学研究院湖南医科大学北京大学第一医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>
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An aptamer-driven DNA nanodevice for improved delivery of synthetic immunostimulants
《Nano Research》2024年第10期9078-9083,共6页Dejie Lu Zhenghan Di Lele Li Jian Zhao Li Zheng 
supported financially by the National Natural Science Foundation of China(Nos.T2322005 and 32101156);Youth Innovation Promotion Association CAS.
Efficient delivery of therapeutics to immune cells remains a formidable challenge for cancer immunotherapy.In this work,we demonstrate that an aptamer-driven DNA nanodevice,constructed through linkage of a synthetic i...
关键词：APTAMER immunostimulatory oligonucleotides DNA nanodevice tumor-associated macrophages cancer therapy 
New insights into the therapeutic approaches for the treatment of tauopathies被引量：2
《Neural Regeneration Research》2024年第5期1020-1026,共7页Himanshi Singh Asmita Das Mohammad Moshahid Khan Tayebeh Pourmotabbed 
supported by National Institute of Health grant number R03AG075597(to MMK and TP);Department of Defense Award Number HT9425-23-1-0043(to MMK).
Tauopathies are a group of neurological disorders,including Alzheimer’s disease and frontotemporal dementia,which involve progressive neurodegeneration,cognitive deficits,and aberrant tau protein accumulation.The dev...
关键词：DEMENTIA gene therapies IMMUNOTHERAPY NEURODEGENERATION OLIGONUCLEOTIDES tau TAUOPATHIES THERAPIES 
Constructing Artificial Nucleobase Compilation to Enable Precise Molecular Medicine
《Chinese Journal of Chemistry》2023年第11期1385-1398,共14页Jingqi Chen Bo Liu Xuan Wang Xueliang Liu Dandan Yang Yu Yang 
supported by grants from the National Natural Science Foundation of China(Nos.22277072 and 22107065);"Clinic Plus"Outstanding Project(Nos.2021ZYB009 and 2021ZYB003)from Shanghai Key Laboratory for Nucleic Acid Chemistry Nanomedicine;Innovative research team of high-level local universities in Shanghai.
Nucleic acids are the hereditary information storage medium of life. Due to its high programmability and good biocompatibility, the applications of nucleic acids are not limited to their natural function. However, the...
关键词：NUCLEOBASES OLIGONUCLEOTIDES Biological activity APTAMER Drug delivery 
An enzyme cascade enables production of therapeutic oligonucleotides in a single operation
《四川生理科学杂志》2023年第6期1087-1087,共1页E R Moody 
Therapeutic oligonucleotides have emerged as a powerful drug modality with the potential to treat a wide range of diseases;however,the rising number of therapies poses a manufacturing challenge.Existing synthetic meth...
关键词：enable COMPLEMENTARY STEPWISE 
Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases被引量：6
《Neural Regeneration Research》2023年第5期959-968,共10页Syed Aoun Mehmood Sherazi Asim Abbasi Abdullah Jamil Mohammad Uzair Ayesha Ikram Shanzay Qamar Adediji Ayomide Olamide Muhammad Arshad Peter J.Fried Milos Ljubisavljevic Ran Wang Shahid Bashir 
Aging is linked to the deterioration of many physical and cognitive abilities and is the leading risk factor for Alzheimer’s disease. The growing aging population is a significant healthcare problem globally that res...
关键词：AGING Alzheimer’s disease DNA sequence EPIGENETICS immune non-coding RNA OLIGONUCLEOTIDES telomere-associated 
Tuning the Stability of the Polyplex Nanovesicles of Oligonucleotides via a Zinc(Ⅱ)-Coordinative Strategy
《Chinese Journal of Polymer Science》2022年第9期1034-1042,共9页Quan Zhou Xiang Li Jia-Jia Xiang You-Qing Shen 
financially supported by the National Key Research and Development Program of China (No.2021YFA1201200);the National Natural Science Foundation of China (Nos. 51833008, 52173141 and 82102192);Zhejiang Provincial Key Research and Development Program (No.2020C01123);China Postdoctoral Science Foundation (No.2019M662059)
Oligonucleotide therapeutics have great potential to target the currently undruggable genes and to generate entirely new therapeutic paradigms in multiple types of disease,thus having attracted much attention in recen...
关键词：Oligonucleotide therapeutics Polyplex nanovesicles Coordinative cationic block Lysosome-targeting 
A highly sensitive bio-barcode immunoassay for multi-residue detection of organophosphate pesticides based on fluorescence antiquenching被引量：1
《Journal of Pharmaceutical Analysis》2022年第4期637-644,共8页Lingyuan Xu Xiuyuan Zhang A.M.Abd El-Aty Yuanshang Wang Zhen Cao Huiyan Jia J.-Pablo Salvador Ahmet Hacimuftuoglu Xueyan Cui Yudan Zhang Kun Wang Yongxin She Fen Jin Lufei Zheng Baima Pujia Jing Wang Maojun Jin Bruce D.Hammock 
supported by the Central Public Interest Scientific Institution Basal Research Fund for the Chinese Academy of Agricultural Sciences(Grant No.:Y2021PT05);National Institute of Environmental Health Science Superfund Research Program(Grant No.:P42 ES004699);National Academy of Sciences(Subaward No.:2000009144);Ningbo Innovation Project for Agro-Products Quality and Safety(Grant No.:2019CXGC007).
Balancing the risks and benefits of organophosphate pesticides(OPs)on human and environmental health relies partly on their accurate measurement.A highly sensitive fluorescence anti-quenching multi-residue bio-barcode...
关键词：Organophosphate pesticides Fluorescence anti-quenching Gold nanoparticles DNA-RNA hybridization DNA oligonucleotides Ribonuclease H 
Delivery of therapeutic oligonucleotides in nanoscale被引量：1
《Bioactive Materials》2022年第1期292-323,共32页Lei Wu Wenhui Zhou Lihua Lin Anhong Chen Jing Feng Xiangmeng Qu Hongbo Zhang Jun Yue 
This work was financially supported by the Natural Science Foundation of China(81871472);Natural Science Foundation of Guangdong Province(Project No.2019A1515010696 and 2021A1515012333);Shenzhen Municipal Science,Technology and Innovation Commission(Project No.JCYJ20190807163003704);“100 Talents Program”of the start-up foundation from Sun Yat-sen University,Academy of Finland(328933)and Sigrid Jus´elius Foundation.
Therapeutic oligonucleotides(TOs)represent one of the most promising drug candidates in the targeted cancer treatment due to their high specificity and capability of modulating cellular pathways that are not readily d...
关键词：Therapeutic oligonucleotides NANOPARTICLES ANTI-CANCER Targeted delivery Clinical translation 
The research group of Xinjing Tang developed efficient inhibition of SARS-CoV-2 using chimeric oligonucleotides through RNase L activation
《Journal of Chinese Pharmaceutical Sciences》2021年第7期621-622,共2页无 
近日,学术期刊《Angewandte Chemie International Edition》在线发表了北京大学药学院天然药物及仿生药物国家重点实验室汤新景研究团队题为"Efficient Inhibition of SARS-CoV-2 Using Chimeric oligonucleotides through RNase L Act...
关键词：病毒RNA 反义核酸 北京大学药学院 学术期刊 RNASE 嵌合 招募 
Phosphate-Methylated Oligonucleotides Past, Present and Future
《Journal of Biophysical Chemistry》2020年第3期27-42,共16页Henk M. Buck 
At the moment, w...
关键词：Anti Sense Oligonucleotides (ASOs) Phosphate-Methylated DNA and RNA HIV COVID-19 Neurological Diseases PCR Gene Chip 
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