THERAPIES

作品数:644被引量:2261H指数:20
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相关领域:医药卫生更多>>
相关作者:董志勇邱仙土王成硕石晶杨青青更多>>
相关机构:莆田学院附属医院迪肯大学美国西北大学中国人民解放军联勤保障部队第九八八医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划北京市自然科学基金中国博士后科学基金更多>>
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Towards mechanism-based tau-targeted therapies
《Neural Regeneration Research》2026年第2期687-688,共2页Lidia Bakota Roland Brandt 
Tau plays a crucial role in several neurodegenerative diseases,collectively referred to as tauopathies.Therefore,targeting potential pathological changes in tau could enable useful therapeutic interventions.However,ta...
关键词:tau targeted therapies cellular components mechanism based therapies cellular componentswhich cellular models MICROTUBULES TAUOPATHIES neurodegenerative diseasescollectively 
Alzheimer's disease treatment landscape:current therapies and emerging mechanism-targeted approaches
《Neural Regeneration Research》2025年第12期3531-3532,共2页Eleen Yang Khaled S.Abd-Elrahman 
supported by a New Investigator grant from the Alzheimer’s Society of Canada;research grant from Djavad Mowafaghian Centre for Brain Health to KSAE。
Alzheimer's disease (AD) is an age-related neurodegenerative disease that involves a progressive decline in memory,thinking,a nd learning.AD has been studied rigorously for more than 50 years yet there is a marked lac...
关键词:ALZHEIMER diagnosis LANDSCAPE 
Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury
《Neural Regeneration Research》2025年第11期3063-3075,共13页Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles W.Plant 
supported by Ohio State Start Up Fund;National Institutes of Health(NIH);Department of Defense(DoD);Wings for Life Spinal Cord Research Foundation,Wings for Life Spinal Cord Research Foundation(Austria);California Institute of Regenerative Medicine(CIRM);International Spinal Research Trust(United Kingdom);Stanford University Bio-X Program Interdisciplinary Initiatives Seed Grant IIP-7;Dennis Chan Foundation;Klein Family Fund;Lucile Packard Foundation for Children's Health;Stanford Institute for Neuro-Innovation and Translational Neurosciences(SINTN);Saunders Family Neuroscience Fund;James Doty Neurosurgery Fund;Hearst Neuroscience Fund;Eileen Bond Research Fund(to GP)。
In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative medicine.Considering the non-regenerative nature of the mature central nervous system,the c...
关键词:axon regeneration central nervous system regeneration induced pluripotent stem cells NEUROTRAUMA regenerative medicine spinal cord injury stem cell therapy 
Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases
《Neural Regeneration Research》2025年第11期3095-3112,共18页Fengcheng Deng Dan Yang Lingxi Qing Yifei Chen Jilian Zou Meiling Jia Qian Wang Runda Jiang Lihua Huang 
supported by the National Natural Science Foundation of China,No.82003965;the Science and Technology Research Project of Sichuan Provincial Administration of Traditional Chinese Medicine,No.2024MS167(to LH);the Xinglin Scholar Program of Chengdu University of Traditional Chinese Medicine,No.QJRC2022033(to LH);the Improvement Plan for the'Xinglin Scholar'Scientific Research Talent Program at Chengdu University of Traditional Chinese Medicine,No.XKTD2023002(to LH);the 2023 National Project of the College Students'Innovation and Entrepreneurship Training Program at Chengdu University of Traditional Chinese Medicine,No.202310633028(to FD)。
The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhance...
关键词:cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway STRATEGY THERAPIES 
Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives被引量:1
《Neural Regeneration Research》2025年第11期3151-3171,共21页Fatima Aldali Chunchu Deng Mingbo Nie Hong Chen 
supported by the Key Research and Development Project of Hubei Province of China,2022BCA028(to HC)。
“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal cord.Peripheral nerve injury results in movements or sensation impairments,and represents a serious public health pro...
关键词:clinical trials EXOSOME extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments 
Hepatitis B virus genotype distribution and mutation patterns:Insights and clinical implications for hepatitis B virus positive patients
《World Journal of Experimental Medicine》2025年第2期72-82,共11页Manisha M Ratnaparkhi Chanda R Vyawahare Nageswari R Gandham 
Hepatitis B virus(HBV)infection is still a major worldwide health concern,contributing to chronic liver disorders like hepatocellular carcinoma(HCC).This review comprehensively analyzes HBV genotype distribution,mutat...
关键词:Chronic hepatitis Viral resistance Antiviral therapies Disease progression Personalized treatment 
Combinatorial therapies for spinal cord injury repair
《Neural Regeneration Research》2025年第5期1293-1308,共16页Carla S.Sousa Andreia Monteiro António J.Salgado Nuno A.Silva 
funded by National funds,through the Foundation for Science and Technology (FCT)-project UIDB/50026/2020 (DOI 10.54499/UIDB/50026/2020),UIDP/50026/2020 (DOI 10.54499/UIDP/50026/2020) and LA/P/0050/2020 (DOI 10.54499/LA/P/0050/2020)(to NAS);Financial support was also provided by Prémios Santa Casa Neurociências–Prize Melo e Castro for Spinal Cord Injury Research (MC-18-2021);Wings for Life Spinal Cord Research Foundation (WFL-PT-14/23)(to NAS)。
Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed t...
关键词:electric stimulation neural tissue regeneration NEUROPROTECTION POLYTHERAPY spinal cord injury 
Cellular therapeutics and immunotherapies in wound healing-on the pulse of time?
《Military Medical Research》2025年第2期242-263,共22页Lioba Huelsboemer Leonard Knoedler Alejandro Kochen Catherine T.Yu Helia Hosseini Katharina S.Hollmann Ashley E.Choi Viola A.Stögner Samuel Knoedler Henry C.Hsia Bohdan Pomahac Martin Kauke-Navarro 
supported by grants from the German Research Foundation (DFG)
Chronic,non-healing wounds represent a significant challenge for healthcare systems worldwide,often requiring significant human and financial resources.Chronic wounds arise from the complex interplay of underlying com...
关键词:Chronic wounds Wound healing Wound healing disorder BIOFILM IMMUNOTHERAPIES Cellular therapies 
Oxygen nanobubbles of ICG dimers achieve self-cascade photothermal and photodynamic therapy for hypoxia-reversible tumor treatment
《Nano Research》2025年第4期325-336,共12页Xiang Sun Zheng Zhang Moran Wang Yuqin Chen Xiang Meng Wenjun Zhao Juan Jin Wanghanqi Yang Chengwan Xia Yuxin Wang Shengliang Li Bin Huang Ning Gu 
supported by the National Key R&D Program of China(No.2023YFF0713600);the National Natural Science Foundation of China(Nos.62375138,and 52173135);the National Natural Science Innovative Research Group Project(No.61821002);the Frontier Fundamental Research Program of Jiangsu Province for Leading Technology(No.BK 20222002);the Natural Science Foundation of Jiangsu Province(No.BK 20231523);Jiangsu Specially Appointed Professorship.
Simultaneous photothermal and photodynamic therapies(PTT and PDT)hold great promise for noninvasive tumor therapy.However,effective regulation of PTT and PDT with optimal synergistic effects remains a challenge.To dat...
关键词:indocyanine green(ICG)dimer oxygen nanobubble J-aggregate self-cascade photothermal therapies(PTT) photodynamic therapies(PDT) 
Conversion treatment for advanced intrahepatic cholangiocarcinoma:Opportunities and challenges
《World Journal of Gastroenterology》2025年第15期24-41,共18页Jun-Jie Liu Mi Zhou Tong Yuan Zhi-Yong Huang Zun-Yi Zhang 
The prevalence of intrahepatic cholangiocarcinoma(ICC)is increasing globally.Despite advancements in comprehending this intricate malignancy and formulating novel therapeutic approaches over the past few decades,the p...
关键词:Intrahepatic cholangiocarcinoma Conversion treatment DOWNSTAGING Combination therapy Chemotherapy IMMUNOTHERAPY Locoregional therapies 
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