MICROTUBULES

作品数：127被引量：213H指数：8
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Towards mechanism-based tau-targeted therapies
《Neural Regeneration Research》2026年第2期687-688,共2页Lidia Bakota Roland Brandt 
Tau plays a crucial role in several neurodegenerative diseases,collectively referred to as tauopathies.Therefore,targeting potential pathological changes in tau could enable useful therapeutic interventions.However,ta...
关键词：tau targeted therapies cellular components mechanism based therapies cellular componentswhich cellular models MICROTUBULES TAUOPATHIES neurodegenerative diseasescollectively 
Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice
《Neural Regeneration Research》2025年第8期2348-2360,共13页Mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel 
supported by the Koeln Fortune Program/Faculty of Medicine,University of Cologne,the Alzheimer Forschung Initiative e.V.(grant#22039,to HZ);open-access funding from the DFG/GRC issued to the University of Cologne;Alzheimer Forschung Initiative e.V.for Open Access Publishing(a publication grant#P2401,to MAAK)。
TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon.TAU is missorted and aggregated in an array of diseases known as tauopathies.Microtubules are essential for neuronal...
关键词：human induced pluripotent stem cell MICROTUBULES P301L pR5 mice TAU TAUOPATHY tubulin code 
The plant retromer components SNXs bind to ATG8 and CLASP to mediate autophagosome movement along microtubules
《Molecular Plant》2025年第3期416-436,共21页Yanglan Liao Xibao Li Wenlong Ma Xinyi Lin Jiayi Kuang Xuanang Zheng Zien Li Fanfan Qiao Chuanliang Liu Jun Zhou Faqiang Li Ruixi Li Byung-Ho Kang Hongbo Li Caiji Gao 
supported by grants from the National Natural Science Foundation of China(32270291,32061160467,32470797,and 31870171);the Guangdong Province Rural Revitalization Strategy Special Funding for Seed Industry Vitalization to C.G.,the NSFC grant(32000365,32370329);Guangdong Basic and Applied Basic Research Foundation(2021A1515010913,2024B1515020043);H.L.,and the Research Grant Council of Hong Kong(GRF14113921,GRF14109222,GRF14110823,N_CUHK462/22,and C4014-23G)to B.-H.K.
In eukaryotic cells,autophagosomes are double-membrane vesicles that are highly mobile and traffic along cytoskeletal tracks.While core autophagy-related proteins(ATGs)and other regulators involved in autophagosome bi...
关键词：autophagy SNX CLASP MICROTUBULE autophagosome trafficking Arabidopsis thaliana 
Host cytoskeleton and membrane network remodeling in the regulation of viral replication
《Biophysics Reports》2025年第1期34-45,共12页Xuedi Gao Xinming Chen Letian Yu Shuangshuang Zhao Yaming Jiu 
Viral epidemics pose major threats to global health and economies.A hallmark of viral infection is the reshaping of host cell membranes and cytoskeletons to form organelle-like structures,known as viral factories,whic...
关键词：Viral replication factory Cytoskeleton Actin filaments MICROTUBULES Intermediate filaments Rearrangement of cellular membranes 
Cancer nuclear envelope rupture and repair in taxane resistance
《Medical Review》2024年第6期522-530,共9页Ana P.Xu Lucy B.Xu Elizabeth R.Smith Joshua S.Fleishman Zhe-Sheng Chen Xiang-Xi Xu 
partially supported by NIH funding R01 CA095071,CA79716,and CA75389 to XX from NCI,NIH;seed funding from Sylvester Comprehensive Cancer Center,University of Miami.
Taxanes,including paclitaxel,docetaxel,and cabazitaxel,are key agents in cancer treatment,often used as frontline chemotherapy drugs in combination with other agent(s)(commonly carboplatin)and as second-line treatment...
关键词：chemotherapy drug resistance TAXANES PACLITAXEL MICROTUBULES nuclear envelope 
How do neurons age?A focused review on the aging of the microtubular cytoskeleton被引量：1
《Neural Regeneration Research》2024年第9期1899-1907,共9页Brad Richardson Thomas Goedert Shmma Quraishe Katrin Deinhardt Amritpal Mudher 
funded by the Gerald Kerkut Charitable Trust (GKT)(to BR)
Aging is the leading risk factor for Alzheimer’s disease and other neurodegenerative diseases. We now understand that a breakdown in the neuronal cytoskeleton, mainly underpinned by protein modifications leading to t...
关键词：age-related changes AGING CYTOSKELETON MICROTUBULES neuronal morphology 
A polarized multicomponent foundation upholds ciliary central microtubules
《Journal of Molecular Cell Biology》2024年第8期19-32,共14页Qingxia Chen Huijie Zhao Xinwen Pan Chuyu Fang Benhua Qiu Jingting Guo Xiumin Yan Xueliang Zhu 
supported by the National Natural Science Foundation of China(31991192,32230027,32270725,32100551,and 32270807);Shandong Natural Science Foundation(2022HWYQ-075).
Cilia’s back-and-forth beat pattern requires a central pair(CP)of microtubules.However,the mechanism by which the CP is upheld above the transition zone(TZ)remains unclear.Here,we showed that a rod-like substructure ...
关键词：basal plate central pair ciliary motility ependyma HYDROCEPHALUS motile cilia 
CSPP1 stabilizes microtubules by capping both plus and minus ends被引量：1
《Journal of Molecular Cell Biology》2024年第2期36-46,共11页Zhikai Wang Wenwen Wang Shuaiyu Liu Fengrui Yang Xu Liu Shasha Hua Lijuan Zhu Aoqing Xu Donald LHill Dongmei Wang Kai Jiang Jennifer Lippincott-Schwartz Xing Liu Xuebiao Yao 
supported by grants from the Ministry of Science and Technology of China and the National Natural Science Foundation of China(2022YFA1303100,32090040,92254302,2022YFA0806800,91854203,31621002,2017YFA0503600,21922706,and 92153302 to Xing Liu,2022YFA1302700 to Z.W.,32100612 to Xu Liu);the Ministry of Education of China(IRT_17R102,20113402130010,and YD2070006001 to Xing Liu);the Plans for Major Provincial Science&Technology Projects of Anhui Province(202303a0702003 to Xing Liu);the Fundamental Research Funds for the Central Universities(KB9100000007 and KB9100000013 to Xing Liu);University of Science and Technology of China Start-up Fund(KY9990000167 to Z.W.);Zhejiang Provincial Natural Science Foundation(LY23C070002 to W.W.)。
Although the dynamic instability of microtubules(MTs)is fundamental to many cellular functions,quiescent MTs with unattached free distal ends are commonly present and play important roles in various events to power ce...
关键词：CSPP1 MICROTUBULE plus end minus end capping 
Connecting neurodevelopment to neurodegeneration:a spotlight on the role of kinesin superfamily protein 2A(KIF2A)被引量：1
《Neural Regeneration Research》2024年第2期375-379,共5页Nuria Ruiz-Reig Janne Hakanen Fadel Tissir 
Fund for Scientific Research(FNRS)PDR T0236.20;FNRS-Exellence of Science 30913351;FNRS CDR J.0175.23(to FT)。
Microtubules play a central role in cytoskeletal changes during neuronal development and maintenance.Microtubule dynamics is essential to polarity and shape transitions underlying neural cell division,differentiation,...
关键词：brain disorders cortical malformations KINESIN MICROTUBULES NEURODEGENERATION NEURODEVELOPMENT 
Wide grain 4,encoding an alpha-tubulin,regulates grain size by affecting cell expansion in rice
《The Crop Journal》2023年第6期1931-1936,共6页Yi Liu Lianan Guo Guoli Qu Yang Xiang Xu Zhao Hua Yuan Ting Li Liangzhu Kang Shiwen Tang Bin Tu Bingtian Ma Yuping Wang Shigui Li Weilan Chen Peng Qin 
the National Natural Science Foundation of China(32121003),the Sichuan Science and Technology Program(2022ZDZX0012,2022YFQ0026);the Natural Science Foundation of Sichuan province(2022NSFSC1667).
Rice is one of the three most important food crops in the world.Increasing rice yield is an effective way to ensure food security.Grain size is a key factor affecting rice yield;however,the genetic and molecular mecha...
关键词：Cell size MICROTUBULES Oryza sativa WG4 
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