supported by the National Natural Science Foundation of China,Nos.82171347,82371362;the Natural Science Foundation of Hunan Province,No.2022JJ30971;the Scientific Research Project of Hunan Provincial Health Commission of China,No.202204040024(all to GX).
A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation.This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiolog...
Hydrocephalus is a medical condition caused by an abnormal cerebrospinal fluid (CSF) buildup in the brain’s ventricles. This excess fluid causes the ventricles to enlarge, increasing pressure within the brain. CSF ty...
supported by grants from the China National Natural Science Foundation(82130052 and 81925017 to Tao Li,82001690 to Hong Cai)。
Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia coordinately.The ependymal denudation or ciliary dysfunction causes hydroce...
Background Many complications may occur after placement of the ventriculoperitoneal shunt (VP shunt) for hydrocephalus, and delayed shunt insufficiency (DSI) is among the most common. It is often caused by abdominal a...
supported by DOD-ARMY:Army Medical Research Acquisition Activity(USAMRAA)under a CDMRP(Congressionally Directed Medical Research Program)grant W81XWH2010805,“A Miniaturized Valve that Mimics Functional Arachnoid Granulations to Treat Hydrocephalus”.
Hydrocephalus is characterized by the accumulation of excess cerebrospinal fluid(CSF)in the cranium due to an imbalance between production and absorption of CSF.The standard treatment involves the implantation of a sh...
the National Natural Science Foundation of China(82201501);the Natural Science Foundation of Sichuan Province(2023NSFC1581,China);1·3.5 projects for disciplines of excellence-Clinical Research Incubation Project,West China Hospital,Sichuan University(No.2020HXFH013,China);Sichuan Science and Technology Program(22ZDYF2619,China)for financial support.
The choroid plexus(ChP)serves as the principal origin of cerebrospinal fluid(CSF).CSF hypersecretion due to ChP inflammation has emerged as an important pathogenesis of hydrocephalus recently.Nevertheless,the precise ...
Ependymomas are a somewhat diverse category of glial tumors that often develop from the lining of the brain’s ventricles, or the spinal cord’s central canal. They make up 5% of all neuroepithelial tumors, 10% of pae...
Background Very few adequately powered studies exploring early thresholds for intervention in the management of post-hemorrhagic ventricular dilatation(PHVD)in preterm infants have identified consistent neurodevelopme...
supported by the National Natural Science Foundation of China(31991192,32230027,32270725,32100551,and 32270807);Shandong Natural Science Foundation(2022HWYQ-075).
Cilia’s back-and-forth beat pattern requires a central pair(CP)of microtubules.However,the mechanism by which the CP is upheld above the transition zone(TZ)remains unclear.Here,we showed that a rod-like substructure ...
supported by the Korea Medical Device Development Fund grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Trade,Industry and Energy,the Ministry of Health&Welfare,the Ministry of Food and Drug Safety)(Project Number:1711138055,KMMDF_PR_20200901_0057).
Background Advancements in neonatal care have increased preterm infant survival but paradoxically raised intraventricular hemorrhage(IVH)rates.This study explores IVH prevalence and long-term outcomes of very low birt...