Long-term outcomes of very low birth weight infants with intraventricular hemorrhage:a nationwide population study from 2011 to 2019  

作　　者：Joonsik Park Sook-Hyun Park Yu-ra Kwon So Jin Yoon Joo Hee Lim Jung Ho Han Jeong Eun Shin Ho Seon Eun Min Soo Park Soon Min Lee 

机构地区：[1]Department of Pediatrics,Yonsei University College of Medicine,211 Eonjuro Gangnamgu,Seoul 06273,Republic of Korea

出　　处：《World Journal of Pediatrics》2024年第7期692-700,共9页世界儿科杂志（英文版）

基　　金：supported by the Korea Medical Device Development Fund grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Trade,Industry and Energy,the Ministry of Health&Welfare,the Ministry of Food and Drug Safety)(Project Number:1711138055,KMMDF_PR_20200901_0057).

摘　　要：Background Advancements in neonatal care have increased preterm infant survival but paradoxically raised intraventricular hemorrhage(IVH)rates.This study explores IVH prevalence and long-term outcomes of very low birth weight(VLBW)infants in Korea over a decade.Methods Using Korean National Health Insurance data(NHIS,2010-2019),we identified 3372 VLBW infants with IVH among 4,129,808 live births.Health-related claims data,encompassing diagnostic codes,diagnostic test costs,and administered procedures were sourced from the NHIS database.The results of the developmental assessments are categorized into four groups based on standard deviation(SD)scores.Neonatal characteristics and complications were compared among the groups.Logistic regression models were employed to identify significant changes in the incidence of complications and to calculate odds ratios with corresponding 95%confidence intervals for each risk factor associated with mortality and morbidity in IVH.Long-term growth and development were compared between the two groups(years 2010-2013 and 2014-2017).Results IVH prevalence was 12%in VLBW and 16%in extremely low birth weight(ELBW)infants.Over the past decade,IVH rates increased significantly in ELBW infants(P=0.0113),while mortality decreased(P=0.0225).Major improvements in certain neurodevelopmental outcomes and reductions in early morbidities have been observed among VLBW infants with IVH.Ten percent of the population received surgical treatments such as external ventricular drainage(EVD)or a ventriculoperitoneal(VP)shunt,with the choice of treatment methods remaining consistent over time.The IVH with surgical intervention group exhibited higher incidences of delayed development,cerebral palsy,seizure disorder,and growth failure(height,weight,and head circumference)up to 72 months of age(P<0.0001).Surgical treatments were also significantly associated with abnormal developmental screening test results.Conclusions The neurodevelopmental outcomes of infants with IVH,especially those subjected to surgi

关 键 词：Cerebral intraventricular hemorrhage DEVELOPMENTAL HYDROCEPHALUS MORTALITY Posthemorrhagic ventricular dilatation SURGERY 

分 类 号：R72[医药卫生—儿科] R742[医药卫生—临床医学]