NEUROINFLAMMATION

作品数:615被引量:2553H指数:20
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相关领域:医药卫生更多>>
相关作者:朱刚唐俊晏勇潘艳芳贾晓涛更多>>
相关机构:华中农业大学第三军医大学西南医院中国药理学会安徽医科大学更多>>
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相关基金:国家自然科学基金中国博士后科学基金北京市自然科学基金上海市自然科学基金更多>>
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Microglial intervention in ischemic stroke:Roles and intervention strategies
《Neural Regeneration Research》2026年第2期443-454,共12页Cuiling Ji Lixinbei Sheng Kaijun Han Ping Yuan Wei Li Lu Chen Yongyue Gao 
supported by the National Natural Science Foundation of China,82471345(to LC);the Key Research and Development Program for Social Development by the Jiangsu Provincial Department of Science and Technology.No.BE2022668(to LC).
Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a...
关键词:blood-brain barrier ischemic stroke MICROGLIA nerve regeneration NEUROINFLAMMATION NEUROPROTECTION oxidative stress polarization signaling pathways therapeutic strategies 
What is the pathophysiology of inflammation-induced cortical injury in the perinatal brain?
《Neural Regeneration Research》2026年第2期502-505,共4页Sharmony B.Kelly Alistair J.Gunn Rodney W.Hunt Robert Galinsky 
supported by National Health and Medical Research Council of Australia(APP1090890 and APP1164954);Cerebral Palsy Alliance(ERG02123);the Victorian Government’s Operational Infrastructure Support Program。
Perinatal exposure to infection/inflammation is highly associated with neural injury,and subsequent impaired cortical growth,disturbances in neuronal connectivity,and impaired neurodevelopment.However,our understandin...
关键词:anti-inflammatory therapies cerebral cortex CHORIOAMNIONITIS ELECTROENCEPHALOGRAPHY magnetic resonance imaging neonatal sepsis NEURODEVELOPMENT NEUROINFLAMMATION neurons 
Novel insights into non-coding RNAs and their role in hydrocephalus
《Neural Regeneration Research》2026年第2期636-647,共12页Zhiyue Cui Jian He An Li Junqiang Wang Yijian Yang Kaiyue Wang Zhikun Liu Qian Ouyang Zhangjie Su Pingsheng Hu Gelei Xiao 
supported by the National Natural Science Foundation of China,Nos.82171347,82371362;the Natural Science Foundation of Hunan Province,No.2022JJ30971;the Scientific Research Project of Hunan Provincial Health Commission of China,No.202204040024(all to GX).
A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation.This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiolog...
关键词:HYDROCEPHALUS NEURODEVELOPMENT NEUROINFLAMMATION non-coding RNA therapeutic target 
Fat mass and obesity-mediated N^(6)-methyladenosine modification modulates neuroinflammatory responses after traumatic brain injury
《Neural Regeneration Research》2026年第2期730-741,共12页Xiangrong Chen Jinqing Lai Zhe Wu Jianlong Chen Baoya Yang Chunnuan Chen Chenyu Ding 
supported by grants from the Major Projects of Health Science Research Foundation for Middle-Aged and Young Scientist of Fujian Province,China,No.2022ZQNZD01010010;the National Natural Science Foundation of China,No.82371390;Fujian Province Scientific Foundation,No.2023J01725(all to XC).
The neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury.The post-transcriptional modification of N^(6)-methyladenosine is ubiqui...
关键词:ADAM17 epigenetic modification fat mass and obesity N6-methyladenosine MICROGLIA mRNA nerve injury NEUROINFLAMMATION traumatic brain injury tumor necrosis factorα 
Blood-brain barrier disruption and neuroinflammation in the hippocampus of a cardiac arrest porcine model:Single-cell RNA sequencing analysis
《Neural Regeneration Research》2026年第2期742-755,共14页Tangxing Jiang Yaning Li Hehui Liu Yijun Sun Huidan Zhang Qirui Zhang Shuyao Tang Xu Niu Han Du Yinxia Yu Hongwei Yue Yunyun Guo Yuguo Chen Feng Xu 
supported by the National Science Foundation of China,Nos.82325031(to FX),82030059(to YC),82102290(to YG),U23A20485(to YC);Noncommunicable Chronic Diseases-National Science and Technology Major Project,No.2023ZD0505504(to FX),2023ZD0505500(to YC);the Key R&D Program of Shandong Province,No.2022ZLGX03(to YC).
Global brain ischemia and neurological deficit are consequences of cardiac arrest that lead to high mortality.Despite advancements in resuscitation science,our limited understanding of the cellular and molecular mecha...
关键词:Blood-brain barrier disruption cardiac arrest HIPPOCAMPUS microglia NEUROINFLAMMATION neuroprotection NEUTROPHIL oligodendrocyte dysfunction S100A8 single-cell RNA sequencing 
Epilepsy therapy beyond neurons: Unveiling astrocytes as cellular targets
《Neural Regeneration Research》2026年第1期23-38,共16页Yuncan Chen Jiayi Hu Ying Zhang Lulu Peng Xiaoyu Li Cong Li Xunyi Wu Cong Wang 
supported by the National Key Research and Development Program of China,No. 2023YFF0714200 (to CW);the National Natural Science Foundation of China,Nos. 82472038 and 82202224 (both to CW);the Shanghai Rising-Star Program,No. 23QA1407700 (to CW);the Construction Project of Shanghai Key Laboratory of Molecular Imaging,No. 18DZ2260400 (to CW);the National Science Foundation for Distinguished Young Scholars,No. 82025019 (to CL);the Greater Bay Area Institute of Precision Medicine (Guangzhou)(to CW)。
Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the ...
关键词:ASTROCYTE cellular microenvironment drug resistance EPILEPSY EXCITABILITY homeostasis metabolism neural networks NEUROINFLAMMATION neuron 
Microglial polarization pathways and therapeutic drugs targeting activated microglia in traumatic brain injury
《Neural Regeneration Research》2026年第1期39-56,共18页Liping Shi Shuyi Liu Jialing Chen Hong Wang Zhengbo Wang 
supported by the Natural Science Foundation of Yunnan Province,No.202401AS070086(to ZW);the National Key Research and Development Program of China,No.2018YFA0801403(to ZW);Yunnan Science and Technology Talent and Platform Plan,No.202105AC160041(to ZW);the Natural Science Foundation of China,No.31960120(to ZW)。
Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microgl...
关键词:animal model anti-inflammatory drug cell replacement strategy central nervous system mesenchymal stem cell MICROGLIA NEUROINFLAMMATION non-human primate signaling pathway traumatic brain injury 
Hidden face of Parkinson's disease:Is it a new autoimmune disease?
《Neural Regeneration Research》2026年第1期57-61,共5页Min Gi Jo Seon-Hee Kim Seung Pil Yun 
supported by the National Research Foundation of South Korea(2023R1A2C2004516,RS-2023-00219399 to SPY,and 2022R1I1A1A01063513 to MGJ)。
Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease is the ac...
关键词:ASTROCYTE autoimmune response biomarkers clinical implication major histocompatibility complex/human leukocyte antigen MICROGLIA neurodegenerative disease NEUROINFLAMMATION Parkinson's disease T cells Α-SYNUCLEIN 
NLRP3 inflammasome and gut microbiota–brain axis:A new perspective on white matter injury after intracerebral hemorrhage
《Neural Regeneration Research》2026年第1期62-80,共19页Xiaoxi Cai Xinhong Cai Quanhua Xie Xueqi Xiao Tong Li Tian Zhou Haitao Sun 
supported by the Guangdong Basic and Applied Basic Research Foundation,No.2023A1515030045(to HS);Presidential Foundation of Zhujiang Hospital of Southern Medical University,No.yzjj2022ms4(to HS)。
Intracerebral hemorrhage is the most dangerous subtype of stroke,characterized by high mortality and morbidity rates,and frequently leads to significant secondary white matter injury.In recent decades,studies have rev...
关键词:gut microbiota gut microbiota–brain axis immune intracerebral hemorrhage NEUROINFLAMMATION NLRP3 protein stroke THERAPEUTICS white matter injury 
Neuronal plasticity and its role in Alzheimer's disease and Parkinson's disease
《Neural Regeneration Research》2026年第1期107-125,共19页Israt Jahan Mohammad Harun-Ur-Rashid MdAminul Islam Farhana Sharmin Soad K.Al Jaouni Abdullah M.Kaki Samy Selim 
financially supported by King Abdulaziz University,Deanship of Scientific Research(DSR)。
Neuronal plasticity,the brain's ability to adapt structurally and functionally,is essential for learning,memory,and recovery from injuries.In neurodegenerative diseases such as Alzheimer's disease and Parkinson's dise...
关键词:Alzheimer's disease long-term depression long-term potentiation NEUROINFLAMMATION neuronal plasticity Parkinson's disease synaptic plasticity 
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