supported by the National Natural Science Foundation of China,82471345(to LC);the Key Research and Development Program for Social Development by the Jiangsu Provincial Department of Science and Technology.No.BE2022668(to LC).
Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a...
supported by National Health and Medical Research Council of Australia(APP1090890 and APP1164954);Cerebral Palsy Alliance(ERG02123);the Victorian Government’s Operational Infrastructure Support Program。
Perinatal exposure to infection/inflammation is highly associated with neural injury,and subsequent impaired cortical growth,disturbances in neuronal connectivity,and impaired neurodevelopment.However,our understandin...
supported by the National Natural Science Foundation of China,Nos.82171347,82371362;the Natural Science Foundation of Hunan Province,No.2022JJ30971;the Scientific Research Project of Hunan Provincial Health Commission of China,No.202204040024(all to GX).
A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation.This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiolog...
supported by grants from the Major Projects of Health Science Research Foundation for Middle-Aged and Young Scientist of Fujian Province,China,No.2022ZQNZD01010010;the National Natural Science Foundation of China,No.82371390;Fujian Province Scientific Foundation,No.2023J01725(all to XC).
The neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury.The post-transcriptional modification of N^(6)-methyladenosine is ubiqui...
supported by the National Science Foundation of China,Nos.82325031(to FX),82030059(to YC),82102290(to YG),U23A20485(to YC);Noncommunicable Chronic Diseases-National Science and Technology Major Project,No.2023ZD0505504(to FX),2023ZD0505500(to YC);the Key R&D Program of Shandong Province,No.2022ZLGX03(to YC).
Global brain ischemia and neurological deficit are consequences of cardiac arrest that lead to high mortality.Despite advancements in resuscitation science,our limited understanding of the cellular and molecular mecha...
supported by the National Key Research and Development Program of China,No. 2023YFF0714200 (to CW);the National Natural Science Foundation of China,Nos. 82472038 and 82202224 (both to CW);the Shanghai Rising-Star Program,No. 23QA1407700 (to CW);the Construction Project of Shanghai Key Laboratory of Molecular Imaging,No. 18DZ2260400 (to CW);the National Science Foundation for Distinguished Young Scholars,No. 82025019 (to CL);the Greater Bay Area Institute of Precision Medicine (Guangzhou)(to CW)。
Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the ...
supported by the Natural Science Foundation of Yunnan Province,No.202401AS070086(to ZW);the National Key Research and Development Program of China,No.2018YFA0801403(to ZW);Yunnan Science and Technology Talent and Platform Plan,No.202105AC160041(to ZW);the Natural Science Foundation of China,No.31960120(to ZW)。
Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microgl...
supported by the National Research Foundation of South Korea(2023R1A2C2004516,RS-2023-00219399 to SPY,and 2022R1I1A1A01063513 to MGJ)。
Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease is the ac...
supported by the Guangdong Basic and Applied Basic Research Foundation,No.2023A1515030045(to HS);Presidential Foundation of Zhujiang Hospital of Southern Medical University,No.yzjj2022ms4(to HS)。
Intracerebral hemorrhage is the most dangerous subtype of stroke,characterized by high mortality and morbidity rates,and frequently leads to significant secondary white matter injury.In recent decades,studies have rev...
financially supported by King Abdulaziz University,Deanship of Scientific Research(DSR)。
Neuronal plasticity,the brain's ability to adapt structurally and functionally,is essential for learning,memory,and recovery from injuries.In neurodegenerative diseases such as Alzheimer's disease and Parkinson's dise...