What is the pathophysiology of inflammation-induced cortical injury in the perinatal brain?  

作　　者：Sharmony B.Kelly Alistair J.Gunn Rodney W.Hunt Robert Galinsky 

机构地区：[1]The Ritchie Centre,Hudson Institute of Medical Research,Melbourne,VIC,Australia [2]Department of Obstetrics and Gynaecology,Monash University,Melbourne,VIC,Australia [3]Department of Physiology,The University of Auckland,Auckland,New Zealand [4]Monash Newborn,Monash Children’s Hospital,Melbourne,Australia

出　　处：《Neural Regeneration Research》2026年第2期502-505,共4页中国神经再生研究(英文版)

基　　金：supported by National Health and Medical Research Council of Australia(APP1090890 and APP1164954);Cerebral Palsy Alliance(ERG02123);the Victorian Government’s Operational Infrastructure Support Program。

摘　　要：Perinatal exposure to infection/inflammation is highly associated with neural injury,and subsequent impaired cortical growth,disturbances in neuronal connectivity,and impaired neurodevelopment.However,our understanding of the pathophysiological substrate underpinning these changes in brain structure and function is limited.The objective of this review is to summarize the growing evidence from animal trials and human cohort studies that suggest exposure to infection/inflammation during the perinatal period promotes regional impairments in neuronal maturation and function,including loss of high-frequency electroencephalographic activity,and reduced growth and arborization of cortical dendrites and dendritic spines resulting in reduced cortical volume.These inflammation-induced disturbances to neuronal structure and function are likely to underpin subsequent disturbances to cortical development and connectivity in fetuses and/or newborns exposed to infection/inflammation during the perinatal period,leading,in the long term,to impaired neurodevelopment.The combined use of early electroencephalography monitoring with neuroimaging techniques that enable detailed evaluation of brain microstructure,and the use of therapeutics that successfully target systemic and central nervous system inflammation could provide an effective strategy for early detection and therapeutic intervention.

关 键 词：anti-inflammatory therapies cerebral cortex CHORIOAMNIONITIS ELECTROENCEPHALOGRAPHY magnetic resonance imaging neonatal sepsis NEURODEVELOPMENT NEUROINFLAMMATION neurons 

分 类 号：R722.1[医药卫生—儿科]