Hidden face of Parkinson's disease:Is it a new autoimmune disease?  

作　　者：Min Gi Jo Seon-Hee Kim Seung Pil Yun 

机构地区：[1]Department of Pathology,College of Medicine,Kyung Hee University,Seoul,Republic of Korea [2]Department of Pharmacology,Institute of Medical Sciences,College of Medicine,Gyeongsang National University,Jinju,Republic of Korea [3]Department of Convergence Medical Science,College of Medicine,Gyeongsang National University,Jinju,Republic of Korea

出　　处：《Neural Regeneration Research》2026年第1期57-61,共5页中国神经再生研究(英文版)

基　　金：supported by the National Research Foundation of South Korea(2023R1A2C2004516,RS-2023-00219399 to SPY,and 2022R1I1A1A01063513 to MGJ)。

摘　　要：Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease is the accumulation of misfoldedα-synuclein,forming insoluble Lewy bodies in the substantia nigra pars compacta,which contributes to neurodegeneration.Theseα-synuclein aggregates may act as autoantigens,leading to T-cell-mediated neuroinflammation and contributing to dopaminergic cell death.Our perspective explores the hypothesis that Parkinson's disease may have an autoimmune component,highlighting research that connects peripheral immune responses with neurodegeneration.T cells derived from Parkinson's disease patients appear to have the potential to initiate an autoimmune response againstα-synuclein and its modified peptides,possibly leading to the formation of neo-epitopes.Recent evidence associates Parkinson's disease with abnormal immune responses,as indicated by increased levels of immune cells,such as CD4^(+)and CD8^(+)T cells,observed in both patients and mouse models.The convergence of T cells filtration increasing major histocompatibility complex molecules,and the susceptibility of dopaminergic neurons supports the hypothesis that Parkinson's disease may exhibit autoimmune characteristics.Understanding the immune mechanisms involved in Parkinson's disease will be crucial for developing therapeutic strategies that target the autoimmune aspects of the disease.Novel approaches,including precision medicine based on major histocompatibility complex/human leukocyte antigen typing and early biomarker identification,could pave the way for immune-based treatments aimed at slowing or halting disease progression.This perspective explores the relationship between autoimmunity and Parkinson's disease,suggesting that further research could deepen understanding and offer new therapeutic avenues.In this paper,it is organized to provide a comprehensive perspective on the autoimmune aspects of Parkinson's disease

关 键 词：ASTROCYTE autoimmune response biomarkers clinical implication major histocompatibility complex/human leukocyte antigen MICROGLIA neurodegenerative disease NEUROINFLAMMATION Parkinson's disease T cells Α-SYNUCLEIN 

分 类 号：R74[医药卫生—神经病学与精神病学]