NEUTROPHIL

作品数：401被引量：1510H指数：17
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Blood-brain barrier disruption and neuroinflammation in the hippocampus of a cardiac arrest porcine model:Single-cell RNA sequencing analysis
《Neural Regeneration Research》2026年第2期742-755,共14页Tangxing Jiang Yaning Li Hehui Liu Yijun Sun Huidan Zhang Qirui Zhang Shuyao Tang Xu Niu Han Du Yinxia Yu Hongwei Yue Yunyun Guo Yuguo Chen Feng Xu 
supported by the National Science Foundation of China,Nos.82325031(to FX),82030059(to YC),82102290(to YG),U23A20485(to YC);Noncommunicable Chronic Diseases-National Science and Technology Major Project,No.2023ZD0505504(to FX),2023ZD0505500(to YC);the Key R&D Program of Shandong Province,No.2022ZLGX03(to YC).
Global brain ischemia and neurological deficit are consequences of cardiac arrest that lead to high mortality.Despite advancements in resuscitation science,our limited understanding of the cellular and molecular mecha...
关键词：Blood-brain barrier disruption cardiac arrest HIPPOCAMPUS microglia NEUROINFLAMMATION neuroprotection NEUTROPHIL oligodendrocyte dysfunction S100A8 single-cell RNA sequencing 
Comparison of the pathogenicity and neutrophil and monocyte response between SARS-CoV-2 prototype and Omicron BA.1 in a lethal mouse model
《Animal Models and Experimental Medicine》2025年第4期707-717,共11页Na Rong Jing Wu Binbin Zhao Wanjun Peng Hekai Yang Gengxin Zhang Dangting Ruan Xiaohui Wei Jiangning Liu 
supported by Beijing Natural Science Foundation(Grant No.Z210014);National Natural Science Foundation of China(Grant No.32070543);National Key Research and Development Project of China(Grant No.2022YFC2303404);CAMS Innovation Fund for Medical Sciences(CIFMS)(Grant No.2022-12M-CoV19-002)
Background:SARS-CoV-2,first identified in late 2019,has given rise to numerous variants of concern(VOCs),posing a significant threat to human health.The emer-gence of Omicron BA.1.1 towards the end of 2021 led to a pa...
关键词：animal model SARS-CoV-2 Omicron BA.1 MONOCYTE NEUTROPHIL 
Cell polarization in ischemic stroke: molecular mechanisms and advances被引量：4
《Neural Regeneration Research》2025年第3期632-645,共14页Yuanwei Li Xiaoxiao Xu Xuan Wu Jiarui Li Shiling Chen Danyang Chen Gaigai Li Zhouping Tang 
supported by the National Natural Science Foundation of China, Nos.82201474 (to GL), 82071330 (to ZT), and 92148206 (to ZT);Key Research and Discovery Program of Hubei Province, No.2021BCA109 (to ZT)。
Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modu...
关键词：astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways STROKE 
The impact of aging on neutrophil functions and the contribution to periodontitis
《International Journal of Oral Science》2025年第1期20-31,共12页Zi Wang Anish Saxena Wenbo Yan Silvia M.Uriarte Rafael Siqueira Xin Li 
The increasing aging population and aging-associated diseases have become a global issue for decades.People over 65 show an increased prevalence and greater severity of periodontitis,which poses threats to overall hea...
关键词：NEUTROPHIL PERIOD IMPAIRED 
Knowing when to stop:MICL self-regulates neutrophil NETosis
《Cell Research》2025年第2期89-90,共2页Hanjoo Brian Shim Justin François Deniset Paul Kubes 
In a recent study published in Nature,Malamud et al.identified how neutrophil MICL recognizes neutrophil extracellular traps(NETs).This recognition suppresses further neutrophil activation and NET production,thereby p...
关键词：thereby MIGRATE NEUTROPHIL 
Significance of the neutrophil-to-lymphocyte ratio and the platelet-tolymphocyte ratio as prognostic predictors after liver transplantation
《World Journal of Transplantation》2025年第2期237-244,共8页Marco Maria Pascale Francesco Frongillo Pierangelo Vasta Giuseppe Massimiani Erida Nure Salvatore Agnes 
BACKGROUND The use of biomarkers,such as the neutrophil-to-lymphocyte ratio(NLR)and the neutrophil-to-platelet ratio(NPR),has shown promise in evaluating early outcomes after medical,interventional,and surgical treatm...
关键词：Liver transplantation Immunobiomarkers Neutrophil-to-lymphocyte ratio Neutrophil-to-platelet ratio Postoperative complications 
The predictive value of NLR and SII in anti⁃MDA5 antibody⁃positive dermatomyositis with rapidly progressive interstitial lung disease
《南京医科大学学报(自然科学版)》2025年第2期196-207,共12页CAI Qingqing YOU Hanxiao WANG Lei LÜChengyin SHI Yumeng QIU Yulu WU Lingyun WANG Fang ZHANG Miaojia TAN Wenfeng 
国家自然科学基金(82171794,82071827,82271844);国家自然科学青年基金(82302041);国家重点研发计划课题(2021YFC2501305);江苏省科教能力提升项目(JSDW202203);宿迁市科技计划(KY202201,KY202302);江苏省医院临床能力提升项目(JSPH⁃MB⁃2023⁃13,JSPH⁃MA⁃2002⁃6)。
Objective:To evaluate the predictive value of the neutrophil⁃to⁃lymphocyte ratio(NLR)and the systemic immune⁃inflammation index(SII)in predicting patients with anti⁃melanoma differentiation⁃associated gene 5⁃positive(...
关键词：anti⁃melanoma differentiation⁃associated gene 5⁃positive dermatomyositis neutrophil⁃to⁃lymphocyte ratio rapidly pro⁃gressive interstitial lung disease systemic immune⁃inflammation index 
Tumor derived cell-free nucleic acid upregulates programmed death-ligand 1 expression in neutrophil via intracellular Toll-like receptor signaling
《Cancer Communications》2025年第1期4-8,共5页Suguru Saito Duo-Yao Cao Tomohiro Shibata Yan Liu Aoi Otagiri-Hoshi Xiaojiang Cui Kenneth E.Bernstein 
supported by the National Institutes of Health grants(R01AI164519,2R01CA151610,R21CA280458);American Heart Association’s Career Development award(23CDA1052548);U.S.Department of Defense(W81XWH-18-1-0067)and the Glazer Foundation.
Neutrophils are innate immune cells that function predominantly against pathogens,while recent studies have revealed additional crucial roles in various diseases,including cancers[1–3].For instance,neutrophils expres...
关键词：DEATH diseases programmed 
Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms
《Cancer Communications》2025年第1期15-42,共28页Jiali Yao Linlin Ji Guang Wang Jin Ding 
National Natural Science Foundation of China,Grant/Award Numbers:82473431,82303184;Innovation Program of Shanghai Municipal Education Commission,Grant/Award Number:20230548;Shanghai Key Laboratory of Cell Engineering,Grant/Award Number:14DZ2272300;Medical Discipline Construction Project of Pudong Health Committee of Shanghai,Grant/Award Number:PWYgf2021-08。
Neutrophils are key mediators of the immune response and play essential roles in the development of tumors and immune evasion.Emerging studies indicate that neutrophils also play a critical role in the immunotherapy r...
关键词：immune resistance IMMUNOTHERAPY NEUTROPHIL tumor Tumor microenvironment 
Neutrophil diversity and function in health and disease
《Signal Transduction and Targeted Therapy》2025年第1期99-147,共49页Fengyuan Zhang Yidan Xia Jiayang Su Fushi Quan Hengzong Zhou Qirong Li Qiang Feng Chao Lin Dongxu Wang Ziping Jiang 
sponsored by the Natural Science Foundation of the Jilin Province(Grant No.82271192);supported by the Jilin Province University Key Laboratory Scientific Research Program under Grant[2019]No.004;the Jilin Education Department Program under Grant JJKH20230259KJ;the Jilin Province Development and Reform Commission Program under Grant 2023C028-6;the Jilin Scientific and Technological Development Program under Grant 20210101010JC,20210203080SF and 20220505033ZP.
Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the pivotal contributors to the acute inflammatory response. Initially, neutrophils were considered the mobile infantry of the innate...
关键词：thereby integrating initiating 
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