Neutrophil diversity and function in health and disease  

作　　者：Fengyuan Zhang Yidan Xia Jiayang Su Fushi Quan Hengzong Zhou Qirong Li Qiang Feng Chao Lin Dongxu Wang Ziping Jiang 

机构地区：[1]Department of Hand and Foot Surgery,Orthopedics Center,The First Hospital of Jilin University,Changchun,People’s Republic of China [2]Institute of Translational Medicine,The First Hospital of Jilin University,Changchun,China [3]Laboratory Animal Center,College of Animal Science,Jilin University,Changchun,China [4]School of Grain Science and Technology,Jilin Business and Technology College,Changchun,China

出　　处：《Signal Transduction and Targeted Therapy》2025年第1期99-147,共49页信号转导与靶向治疗(英文)

基　　金：sponsored by the Natural Science Foundation of the Jilin Province(Grant No.82271192);supported by the Jilin Province University Key Laboratory Scientific Research Program under Grant[2019]No.004;the Jilin Education Department Program under Grant JJKH20230259KJ;the Jilin Province Development and Reform Commission Program under Grant 2023C028-6;the Jilin Scientific and Technological Development Program under Grant 20210101010JC,20210203080SF and 20220505033ZP.

摘　　要：Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the pivotal contributors to the acute inflammatory response. Initially, neutrophils were considered the mobile infantry of the innate immune system, tasked with the immediate response to invading pathogens. However, recent studies have demonstrated that neutrophils are versatile cells, capable of regulating various biological processes and impacting both human health and disease. Cytokines and other active mediators regulate the functional activity of neutrophils by activating multiple receptors on these cells, thereby initiating downstream signal transduction pathways. Dysfunctions in neutrophils and disruptions in neutrophil homeostasis have been implicated in the pathogenesis of numerous diseases, including cancer and inflammatory disorders, often due to aberrant intracellular signaling. This review provides a comprehensive synthesis of neutrophil biological functions, integrating recent advancements in this field. Moreover, it examines the biological roles of receptors on neutrophils and downstream signaling pathways involved in the regulation of neutrophil activity. The pathophysiology of neutrophils in numerous human diseases and emerging therapeutic approaches targeting them are also elaborated. This review also addresses the current limitations within the field of neutrophil research, highlighting critical gaps in knowledge that warrant further investigation. In summary, this review seeks to establish a comprehensive and multidimensional model of neutrophil regulation, providing new perspectives for potential clinical applications and further research.

关 键 词：thereby integrating initiating 

分 类 号：R73[医药卫生—肿瘤]