Knowing when to stop:MICL self-regulates neutrophil NETosis  

作　　者：Hanjoo Brian Shim Justin François Deniset Paul Kubes 

机构地区：[1]Department of Physiology and Pharmacology,University of Calgary,Calgary,AB,Canada [2]Calvin,Phoebe,and Joan Snyder Institute for Chronic Diseases,University of Calgary,Calgary,AB,Canada [3]Department of Cardiac Sciences,University of Calgary,Calgary,AB,Canada [4]Libin Cardiovascular Institute,University of Calgary,Calgary,AB,Canada [5]Department of Biomedical and Molecular Science,Queen’s University,Kingston,ON,Canada [6]These authors contributed equally:Justin François Deniset,Paul Kubes

出　　处：《Cell Research》2025年第2期89-90,共2页细胞研究(英文版)

摘　　要：In a recent study published in Nature,Malamud et al.identified how neutrophil MICL recognizes neutrophil extracellular traps(NETs).This recognition suppresses further neutrophil activation and NET production,thereby preventing a vicious cycle of inflammation.Neutrophils are circulating immune cells that rapidly migrate into infected or injured tissues.Upon recruitment,these cells amplify inflammation by releasing cytokines,proteases,reactive oxygen species(ROS),and neutrophil extracellular traps(NETs)-a sticky web of DNA containing histones and other effector molecules.Of these programs,NETs may be the most potent because they can non-specifically kill cells by disrupting their cell membranes.

关 键 词：thereby MIGRATE NEUTROPHIL 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]