Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms  

作　　者：Jiali Yao Linlin Ji Guang Wang Jin Ding 

机构地区：[1]Clinical Cancer Institute,Center for Translational Medicine,Naval Medical University,Shanghai,China

出　　处：《Cancer Communications》2025年第1期15-42,共28页癌症通讯(英文)

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:82473431,82303184;Innovation Program of Shanghai Municipal Education Commission,Grant/Award Number:20230548;Shanghai Key Laboratory of Cell Engineering,Grant/Award Number:14DZ2272300;Medical Discipline Construction Project of Pudong Health Committee of Shanghai,Grant/Award Number:PWYgf2021-08。

摘　　要：Neutrophils are key mediators of the immune response and play essential roles in the development of tumors and immune evasion.Emerging studies indicate that neutrophils also play a critical role in the immunotherapy resistance in cancer.In this review,firstly,we summarize the novel classification and phenotypes of neutrophils and describe the regulatory relationships between neutrophils and tumormetabolism,flora microecology,neuroendocrine and tumor therapy from a new perspective.Secondly,we review the mechanisms by which neutrophils affect drug resistance in tumor immunotherapy from the aspects of the immune microenvironment,tumor antigens,and epigenetics.Finally,we propose several promising strategies for overcoming tumor immunotherapy resistance by targeting neutrophils and provide new research ideas in this area.

关 键 词：immune resistance IMMUNOTHERAPY NEUTROPHIL tumor Tumor microenvironment 

分 类 号：R73[医药卫生—肿瘤]