EXCITABILITY

作品数：69被引量：120H指数：6
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Effects of Kv1.3 knockout on pyramidal neuron excitability and synaptic plasticity in piriform cortex of mice
《Acta Pharmacologica Sinica》2024年第10期2045-2060,共16页Yong-sheng Zhou Hao-bo Tao Si-si Lv Ke-qin Liang Wen-yi Shi Ke-yi Liu Yun-yun Li Lv-yi Chen Ling Zhou Shi-jin Yin Qian-ru Zhao 
supported by National Natural Sciences Foundation of China(32000685);Knowledge Innovation Program of Wuhan-Shuguang Project(2022020801020412);Natural Sciences Foundation of Hubei Province(2020CFB348);Fundamental Research Funds for the Central Universities,South-Central Minzu University(CZQ23026)to QZ;partly by National Natural Sciences Foundation of China(81373379,81641186);National Key R and D Program of China(2019YFC1712402);Fundamental Research Funds for the Central Universities,South-Central Minzu University(CZZ19005)to SY.
Kv1.3 belongs to the voltage-gated potassium(Kv)channel family,which is widely expressed in the central nervous system and associated with a variety of neuropsychiatric disorders.Kv1.3 is highly expressed in the olfac...
关键词：Kv1.3 piriform cortex neuronal excitability synaptic plasticity olfactory recognition 
How do lateral septum projections to the ventral CA1 influence sociability?
《Neural Regeneration Research》2024年第8期1789-1801,共13页Dan Wang Di Zhao Wentao Wang Fengai Hu Minghu Cui Jing Liu Fantao Meng Cuilan Liu Changyun Qiu Dunjiang Liu Zhicheng Xu Yameng Wang Yu Zhang Wei Li Chen Li 
supported by the National Natural Science Foundation of China,No.82171521(to CL);the Special Funds ofTaishan Scholars Project of Shandong Province,No.tsqn202211368(to CL);the Natural Science Foundation of Shandong Province,Nos.ZR2022YQ65(to CL),ZR2021MH073(to CL),ZR2019PH109(to WW);the Projects of Medical and Health Technology Development Program in Shandong Province,China,Nos.202003090720(to DZ),202003070728(to JL),2019 WS329(to DW);the Scientific Research Foundation of Binzhou Medical University,No.BY2018KJ21(to DW)。
Social dysfunction is a risk factor for several neuropsychiatric illnesses.Previous studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social behaviors.Howeve r,the role ...
关键词：chemogenetics GABA receptor GABAergic neurons glutamatergic neurons lateral septum neural excitability neural projection social novelty social preference ventral CA1 
Soleus arthrogenic muscle inhibition following acute lateral ankle sprain correlates with symptoms and ankle disability but not with postural control
《Journal of Sport and Health Science》2024年第4期559-568,F0003,共11页Kyung-Min Kim Joo-Sung Kim Alan R.Needle 
funded by Texas State University
Background:Acute lateral ankle sprains(ALAS)are associated with long-term impairments and instability tied to altered neural excitability.Arthrogenic muscle inhibition(AMI)has been observed in this population;however,...
关键词：Acute injuries Balance Hoffmann reflex Neural excitability Patient-reported outcomes 
Exercise-induced adaptation of neurons in the vertebrate locomotor system
《Journal of Sport and Health Science》2024年第2期160-171,共12页Yue Dai Yi Cheng Renkai Ge Ke Chen Liming Yang 
supported by grants from the National Natural Science Foundation of China(NSFC)to YD(32171129);from China Postdoctoral Science Foundation to YC(2023M731112);from NSFC to RG(32260216)。
Vertebrate neurons are highly dynamic cells that undergo several alterations in their functioning and physiologies in adaptation to various external stimuli.In particular,how these neurons respond to physical exercise...
关键词：Dendritic plasticity EXCITABILITY Exercise Ion channel modulation Neuron adaptation 
Neuronomodulation of Excitable Neurons
《Neuroscience Bulletin》2024年第1期103-112,共10页Yizhang Chen Lin Xiao Jian Qiu 
supported by grants from the National Natural Science Foundation of China(31970913 and 32170957);the Natural Science Foundation of Guangdong Province(2021A1515012156);National Key Research and Development Program of China(2021ZD0201703);the Key-Area Research and Development Program of Guangdong Province(2019B030335001).
Neuronomodulation refers to the modulation of neural conduction and synaptic transmission(i.e.,the conduction process involved in synaptic transmission)of excitable neurons via changes in the membrane potential in res...
关键词：NEURON Membrane potential EXCITABILITY Chemoactivation Neuronomodulation 
(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission被引量：3
《Acta Pharmacologica Sinica》2023年第8期1600-1611,共12页Yu Wang Xiao-yun Qiu Jia-ying Liu Bei Tan Fei Wang Min-juan Sun Xu-hong Jiang Xu-ming Ji Ceng-lin Xu Yi Wang Zhong Chen 
supported by grants from the National Key R&D Program of China (2021ZD0202803 and 2020YFA0803902);the National Natural Science Foundation of China (82022071);the Natural Science Foundation of Zhejiang Province (LD22H310003);the Research Project of Zhejiang Chinese Medical University (2022JKJNTZ13).
Epilepsy is one common brain disorder,which is not well controlled by current pharmacotherapy.In this study we characterized the therapeutic potential of borneol,a plant-derived bicyclic monoterpene compound,in the tr...
关键词：epilepsy anti-seizure drug (+)-borneol valproate SUBICULUM glutamatergic synaptic transmission 
Biphasic Cholinergic Modulation of Reverberatory Activity in Neuronal
《Neuroscience Bulletin》2023年第5期731-744,共14页Xiao-Wei Li Yi Ren Dong-Qing Shi Lei Qi Fang Xu Yanyang Xiao Pak-Ming Lau Guo-Qiang Bi 
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200);the National Natural Science Foundation of China(31070935 and 62173326);the National Basic Research Program of China(2013CB835100);the Youth Innovation Promotion Association,CAS(2022367)。
Acetylcholine(ACh)is an important neuromod-ulator in various cognitive functions.However,it is unclear how ACh influences neural circuit dynamics by altering cellular properties.Here,we investigated how ACh influ-ence...
关键词：ACETYLCHOLINE Neuronal network REVERBERATION Synaptic current EXCITABILITY 
Activation of metabotropic glutamate receptor 1 regulates hippocampal CA1 region excitability in rats with status epilepticus by suppressing the HCN1 channel
《Neural Regeneration Research》2023年第3期594-602,共9页Xiao-Dan Luo Tao Xiang Si-Jun Li Mei-Gang Ma Mei-Ling Chen Yuan Wu 
supported by the National Natural Science Foundation of China,No.81760242(to MGM).
Dysregulation of hyperpolarization-activated cyclic nucleotide-gated cation(HCN)channels alters neuronal excitability.However,the role of HCN channels in status epilepticus is not fully understood.In this study,we est...
关键词：(RS)-3 5-dihydroxyphenylglycine CA1 region EXCITABILITY H89 HCN1 channel LY367385 MGLUR1 PENTYLENETETRAZOLE status epilepticus 
General Neural Process in Cycling Exercise
《Journal of Science in Sport and Exercise》2023年第1期1-15,共15页Victor Scholler Alain Groslambert Frederic Grappe Sidney Grosprêtre 
Performance in cycling is frequently related to metabolic or biomechanical factors.Overall,the contribution of the neu-rophysiological system during cycling is often poorly considered in performance optimization.Yet,c...
关键词：COGNITION Motor areas ELECTROENCEPHALOGRAPHY Transcranial magnetic stimulation Spinal excitability 
New monoamine antidepressant,hypidone hydrochloride(YL-0919),enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism被引量：3
《Acta Pharmacologica Sinica》2022年第7期1699-1709,共11页Yong-mei Zhang Lu-yu Ye Tian-yu Li Fan Guo Fei Guo Yang Li Yun-feng Li 
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12040220);the National Natural Science Foundation of China(31671049,81773708,81072624,and 81173036);the National Key New Drug Creation Program of China(No.2017ZX09309012,2018ZX09739008,and 2018ZX09711002-002-012).
Hypidone hydrochloride(YL-0919)is a novel antidepressant in clinical phase II trial.Previous studies show that YL-0919 is a selective 5-HT(serotonin)reuptake inhibitor,5-HT1A receptor partial agonist,and 5-HT6 recepto...
关键词：YL-0919 medial prefrontal cortex GABAergic neurons 5-HT1A receptor GAD67-GFP transgenic mice DISINHIBITION FLUOXETINE electrophysiological recording 
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