Neuronomodulation of Excitable Neurons  

作　　者：Yizhang Chen Lin Xiao Jian Qiu 

机构地区：[1]Institute of Neuroscience,Second Military Medical University,Shanghai 200433,China [2]Institute for Brain Research and Rehabilitation,Key Laboratory of Brain,Cognition and Education Sciences of Ministry of Education,South China Normal University,Guangzhou 510631,China [3]Department of Chemical Physiology and Biochemistry,Oregon Health and Science University,Portland,OR 97239,USA

出　　处：《Neuroscience Bulletin》2024年第1期103-112,共10页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(31970913 and 32170957);the Natural Science Foundation of Guangdong Province(2021A1515012156);National Key Research and Development Program of China(2021ZD0201703);the Key-Area Research and Development Program of Guangdong Province(2019B030335001).

摘　　要：Neuronomodulation refers to the modulation of neural conduction and synaptic transmission(i.e.,the conduction process involved in synaptic transmission)of excitable neurons via changes in the membrane potential in response to chemical substances,from spillover neuro-transmitters to paracrine or endocrine hormones circulating in the blood.Neuronomodulation can be direct or indirect,depending on the transduction pathways from the ligand binding site to the ion pore,either on the same molecule,i.e.the ion channel,or through an intermediate step on different molecules.The major players in direct neurono-modulation are ligand-gated or voltage-gated ion channels.The key process of direct neuronomodulation is the binding and chemoactivation of ligand-gated or voltage-gated ion channels,either orthosterically or allosterically,by various ligands.Indirect neuronomodulation involves metabotropic receptor-mediated slow potentials,where steroid hormones,cytokines,and chemokines can implement these actions.Elucidating neuronomodulation is of great significance for understanding the physiological mechanisms of brain function,and the occurrence and treatment of diseases.

关 键 词：NEURON Membrane potential EXCITABILITY Chemoactivation Neuronomodulation 

分 类 号：R741[医药卫生—神经病学与精神病学]