NEURON

作品数：588被引量：1536H指数：16
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Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress
《Neural Regeneration Research》2026年第1期333-345,共13页Yumei Liao Qinghua Zhang Qiaoyun Shi Peng Liu Peiyun Zhong Lingling Guo Zijian Huang Yinghui Peng Wei Liu Shiqing Zhang István Adorján Yumi Fukuzaki Eri Kawashita Xiao-Qi Zhang Nan Ma Xiaoshen Zhang Zoltán Molnár Lei Shi 
supported in part by the National Key Research&Development Program of China,No. 2022YFA1104900 (to LS);the National Natural Science Foundation of China,Nos. 82371175, 82071535 (both to LS), 82101614 (to YP);the International Science and Technology Cooperation Projects of Guangdong Province,No. 2023A0505050121 (to LS);Guangdong Basic and Applied Basic Research Foundation,Nos. 2022B1515130007 (to LS), 2023A1515030012 (to SZ), 2022A1515010666 (to WL);the Science and Technology Program of Guangzhou,Nos. 202102070001 (to LS), 202201010041 (to YP);Shenzhen Basic Research Grant,Nos. JCYJ20200109140414636, JCYJ20230807145103007 (both to WL);awarded a Royal Society Newton Advanced Fellowship,No. AOMS-NAF0051003;in collaboration with Zoltán Molnár,Department of Physiology,Anatomy and Genetics,University of Oxford (2017–2021)。
Neuroserpin, a secreted protein that belongs to the serpin superfamily of serine protease inhibitors, is highly expressed in the central nervous system and plays multiple roles in brain development and pathology. As a...
关键词：endoplasmic reticulum stress ischemia-reperfusion injury NEURON neuronal apoptosis NEUROPROTECTION NEUROSERPIN protein synthesis secretory protein stroke transcriptomic analysis 
Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?
《Neural Regeneration Research》2025年第9期2596-2597,共2页Christopher J.O’Connell Matthew J.Robson 
Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic...
关键词：SUSTAINED ORANGE dynamic 
FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival
《Neural Regeneration Research》2025年第7期2108-2115,共8页Yuhui Kou Zongxue Jin Yusong Yuan Bo Ma Wenyong Xie Na Han 
supported by the National Natural Science Foundation of China,No.81971177(to YK);the Natural Science Foundation of Beijing,No.7222198(to NH);the Peking University People's Hospital Research and Development Fund,No.RDX2021-01(to YK)。
FK506(Tacrolimus)is a systemic immunosuppressant approved by the U.S.Food and Drug Administration.FK506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways ...
关键词：FK506 inflammation motor neurons nerve regeneration NEURON peripheral nerve injury sensory neurons 
Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2
《Neural Regeneration Research》2025年第6期1801-1815,共15页Qing He Zhen Wang Yuchen Wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge Xu Gong Chen 
supported by the Key Project of Guangzhou City,No.202206060002;Science and Technology Project of Guangdong Province,No.2018B030332001;Guangdong Provincial Pearl River Project,No.2021ZT09Y552 (all to GC)。
Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders....
关键词：AQUAPORIN-4 Ascl1 ASTROCYTE cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 REPROGRAMMING 
Glia-to-neuron reprogramming to the rescue?
《Neural Regeneration Research》2025年第5期1395-1396,共2页Jack W.Hickmott Cindi M.Morshead 
supported by Canada First Research Excellence Fund,Medicine by Design(to CMM)。
Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells c...
关键词：programming PASSING proof 
T cell interactions with microglia in immune-inflammatory processes of ischemic stroke
《Neural Regeneration Research》2025年第5期1277-1292,共16页Yuxiao Zheng Zilin Ren Ying Liu Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang 
supported by the National Natural Science Foundation of China,Nos.82104560(to CL),U21A20400(to QW);the Natural Science Foundation of Beijing,No.7232279(to XW);the Project of Beijing University of Chinese Medicine,No.2022-JYB-JBZR-004(to XW)。
The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue regeneration.As the first i...
关键词：BRAIN IMMUNE INFLAMMATION interaction ischemic stroke mechanism MICROGLIA NEURON secondary injury T cells 
Netrin-1 signaling pathway mechanisms in neurodegenerative diseases
《Neural Regeneration Research》2025年第4期960-972,共13页Kedong Zhu Hualong Wang Keqiang Ye Guiqin Chen Zhaohui Zhang 
supported by the National Natural Science Foundation of China(Youth Science Fund Project),No.81901292(to GC);the National Key Research and Development Program of China,No.2021YFC2502100(to GC);the National Natural Science Foundation of China,No.82071183(to ZZ).
Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal sur...
关键词：Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways NETRIN-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C 
Single‑Neuron Reconstruction of the Macaque Primary Motor Cortex Reveals the Diversity of Neuronal Morphology
《Neuroscience Bulletin》2025年第3期525-530,共6页Siyu Li Yan Shen Yefei Chen Zexuan Hong Lewei Zhang Lufeng Ding Chao‑Yu Yang Xiaoyang Qi Quqing Shen Yanyang Xiao Pak‑Ming Lau Zhonghua Lu Fang Xu Guo‑Qiang Bi 
supported by the National Key R&D Program of China(2020YFE0205900 and 2022YEF0203200);the STI 2030-Major Project(2021ZD0200104 and 2022ZD0205203);the Shenzhen Science and Technology Program(RCYX20210706092100003,RCBS20221008093311027,and JCYJ20210324102006018);the Youth Innovation Promotion Association CAS(2022367);the Shenzhen Technological Research Center for Primate Translational Medicine grant(XMHT20220104005).
Dear Editor,The primary motor cortex,also known as MOp in rodents,F1,or M1 in primates[1],plays a crucial role in autonomous motor control.It is interconnected with other motor control structures such as the basal gan...
关键词：habit formation autonomous motor controlit morphology action selectionmotor corticostriatal system NEURON basal gangliathalamusand primary motor cortexalso 
Modulation of autophagy by melatonin and its receptors:implications in brain disorders
《Acta Pharmacologica Sinica》2025年第3期525-538,共14页Chen-ze Zhu Gui-zhi Li Hai-feng Lyu Yang-yang Lu Yue Li Xiang-nan Zhang 
supported by the Fundamental Research Funds for the Zhejiang Provincial Universities(226-2023-00013);the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(SN-ZJU-SIAS-0011);the National Natural Science Foundation of China(82173792);the Jinhua Science and Technology Plan Projects(2023-3-170).
Autophagy plays a crucial role in maintaining neuronal homeostasis and function,and its disruption is linked to various brain diseases.Melatonin,an endogenous hormone that primarily acts through MT1 and MT2 receptors,...
关键词：AUTOPHAGY NEURON MELATONIN melatonin receptor brain disorders 
Neuronal activities drive brain waste clearance through the glymphatic system
《Acta Pharmaceutica Sinica B》2025年第2期1193-1195,共3页Lin-jian Wang Xiwen Ma Jianping Ye 
supported by the National Natural Science Foundation of China(Grant No.32271220).
Neurons are the main organizers of neurological activities in the brain.However,its role remains largely unknown in regulating waste clearance in the brain.This issue is addressed in a recent study published in Nature...
关键词：Alzheimer disease NEURON Glymphatic system Cerebrospinal fluid perfusion Brain clearance 
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