Netrin-1 signaling pathway mechanisms in neurodegenerative diseases  

作　　者：Kedong Zhu Hualong Wang Keqiang Ye Guiqin Chen Zhaohui Zhang 

机构地区：[1]Department of Neurology,Renmin Hospital of Wuhan University,Wuhan,Hubei Province,China [2]Department of Neurology,The First Hospital of Hebei Medical University,Brain Aging and Cognitive Neuroscience Laboratory of Heibei Province,Shijiazhuang,Hebei Province,China [3]Faculty of Life and Health Sciences,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong Province,China

出　　处：《Neural Regeneration Research》2025年第4期960-972,共13页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Youth Science Fund Project),No.81901292(to GC);the National Key Research and Development Program of China,No.2021YFC2502100(to GC);the National Natural Science Foundation of China,No.82071183(to ZZ).

摘　　要：Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function.Increasing amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of cancers.These findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative diseases.Through a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.

关 键 词：Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways NETRIN-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C 

分 类 号：R741.02[医药卫生—神经病学与精神病学]