Modulation of autophagy by melatonin and its receptors:implications in brain disorders  

作　　者：Chen-ze Zhu Gui-zhi Li Hai-feng Lyu Yang-yang Lu Yue Li Xiang-nan Zhang 

机构地区：[1]Institute of Pharmacology&Toxicology,College of Pharmaceutical Sciences,Key Laboratory of Medical Neurobiology of the Ministry of Health of China,Zhejiang University,Hangzhou,310058,China [2]School of Pharmacy,Hangzhou Medical College,Hangzhou,311399,China [3]Jinhua Institute of Zhejiang University,Jinhua,321299,China

出　　处：《Acta Pharmacologica Sinica》2025年第3期525-538,共14页中国药理学报(英文版)

基　　金：supported by the Fundamental Research Funds for the Zhejiang Provincial Universities(226-2023-00013);the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(SN-ZJU-SIAS-0011);the National Natural Science Foundation of China(82173792);the Jinhua Science and Technology Plan Projects(2023-3-170).

摘　　要：Autophagy plays a crucial role in maintaining neuronal homeostasis and function,and its disruption is linked to various brain diseases.Melatonin,an endogenous hormone that primarily acts through MT1 and MT2 receptors,regulates autophagy via multiple pathways.Growing evidence indicates that melatonin’s ability to modulate autophagy provides therapeutic and preventive benefits in brain disorders,including neurodegenerative and affective diseases.In this review,we summarize the key mechanisms by which melatonin affects autophagy and explore its therapeutic potential in the treatment of brain disorders.

关 键 词：AUTOPHAGY NEURON MELATONIN melatonin receptor brain disorders 

分 类 号：R741[医药卫生—神经病学与精神病学]