NEUROSERPIN

作品数：7被引量：22H指数：3
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相关领域：医药卫生更多>>
相关作者：杨雪莲陈立云解龙昌李常新曾进胜更多>>
相关机构：复旦大学中山大学附属第一医院天津医科大学更多>>
相关期刊：《中国神经精神疾病杂志》《Neural Regeneration Research》《中华神经科杂志》更多>>
相关基金：国家自然科学基金国家教育部博士点基金更多>>
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Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress
《Neural Regeneration Research》2026年第1期333-345,共13页Yumei Liao Qinghua Zhang Qiaoyun Shi Peng Liu Peiyun Zhong Lingling Guo Zijian Huang Yinghui Peng Wei Liu Shiqing Zhang István Adorján Yumi Fukuzaki Eri Kawashita Xiao-Qi Zhang Nan Ma Xiaoshen Zhang Zoltán Molnár Lei Shi 
supported in part by the National Key Research&Development Program of China,No. 2022YFA1104900 (to LS);the National Natural Science Foundation of China,Nos. 82371175, 82071535 (both to LS), 82101614 (to YP);the International Science and Technology Cooperation Projects of Guangdong Province,No. 2023A0505050121 (to LS);Guangdong Basic and Applied Basic Research Foundation,Nos. 2022B1515130007 (to LS), 2023A1515030012 (to SZ), 2022A1515010666 (to WL);the Science and Technology Program of Guangzhou,Nos. 202102070001 (to LS), 202201010041 (to YP);Shenzhen Basic Research Grant,Nos. JCYJ20200109140414636, JCYJ20230807145103007 (both to WL);awarded a Royal Society Newton Advanced Fellowship,No. AOMS-NAF0051003;in collaboration with Zoltán Molnár,Department of Physiology,Anatomy and Genetics,University of Oxford (2017–2021)。
Neuroserpin, a secreted protein that belongs to the serpin superfamily of serine protease inhibitors, is highly expressed in the central nervous system and plays multiple roles in brain development and pathology. As a...
关键词：endoplasmic reticulum stress ischemia-reperfusion injury NEURON neuronal apoptosis NEUROPROTECTION NEUROSERPIN protein synthesis secretory protein stroke transcriptomic analysis 
Roles of constitutively secreted extracellular chaperones in neuronal cell repair and regeneration
《Neural Regeneration Research》2023年第4期769-772,共4页Sandeep Satapathy Mark R.Wilson 
Protein quality control involves many processes that jointly act to regulate the expression, localization, turnover, and degradation of proteins, and has been highlighted in recent studies as critical to the different...
关键词：cell viability CLUSTERIN extracellular chaperones inflammation NEUROSERPIN protein misfolding TRANSTHYRETIN Α2-MACROGLOBULIN 
The plasminogen activating system in the pathogenesis of Alzheimer’s disease被引量：4
《Neural Regeneration Research》2021年第10期1973-1977,共5页Manuel Yepes 
This work was supported in part by National Institutes of Health Grant NS-NS091201(to MY)and VA MERIT Award IO1BX003441(to MY).
Dementia is a clinical syndrome that affects approximately 47 million people worldwide and is characterized by progressive and irreversible decline of cognitive,behavioral and sesorimotor functions.Alzheimer’s diseas...
关键词：Alzheimer’s disease amyloid precursor protein amyloidβ NEUROSERPIN PLASMIN plasminogen activating system plasminogen activator inhibitor-1 synapse tissue-type plasminogen activator urokinase-type plasminogen activator 
Inhibiting endogenous tissue plasminogen activator enhanced neuronal apoptosis and axonal injury after traumatic brain injury被引量：10
《Neural Regeneration Research》2020年第4期667-675,共9页Jun-Jie Zhao Zun-Wei Liu Bo Wang Ting-Qin Huang Dan Guo Yong-Lin Zhao Jin-Ning Song 
Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke,but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported.A rat model of traumat...
关键词：apoptosis ASTROCYTES AXONAL INJURY inflammation microglia nerve REGENERATION neural REGENERATION neuronal INJURY neurons NEUROSERPIN tissue PLASMINOGEN activator traumatic brain INJURY 
Tissue plasminogen activator-independent roles of neuroserpin in the central nervous system
《Neural Regeneration Research》2012年第2期146-151,共6页Jiao Ma Yu Tong Dan Yu Meng Mao 
supported by the National Natural Science Foundation of China, No. 30700908, 30772343 and 30973215
A number of studies have confirmed the existence of tissue-type plasminogen activator-independent roles of neuroserpin, a member of the serine protease inhibitor superfamily. In this review article, we aim to clarify ...
关键词：NEUROSERPIN tissue-type plasminogen activator SERPIN cerebral ischemia tumor familial encephalopathy with neuroserpin inclusion bodies 
Neuroserpin在神经系统疾病中的实验研究进展
《中华神经科杂志》2007年第4期281-283,共3页杨雪莲 董强 王亮 
Neuroserpin（NSP）是一种轴突选择性的神经丝氨酸蛋白酶抑制剂。在成人中枢神经系统内，它主要存在于新大脑皮质、海马结构、嗅球和杏仁核，而在大多数丘脑核、尾状核、壳核和小脑细胞中相对缺乏。在大脑内，NSP形成了十二烷基磺酸钠（...
关键词：神经系统疾病 实验研究 丝氨酸蛋白酶抑制剂 十二烷基磺酸钠 纤溶酶原激活剂 Ne 中枢神经系统 纤维蛋白溶酶 
rt-PA应用后MMP-2、MMP-9表达的改变及Neuroserpin的影响被引量：8
《中国神经精神疾病杂志》2003年第4期258-261,T001,共5页陈立云 曾进胜 李常新 温红梅 解龙昌 Nigel P.Birch 黄如训 
"211工程"基金(编号:061);博士点基金(编号:9950)
目的 观察重组组织型纤溶酶原激活剂(rt-PA)对血管再通后基质金属蛋白酶-2(MMP-2)、MMP-9表达的影响以及神经源性丝氨酸蛋白酶抑制剂(neuroserpin,NSP)的干预作用。方法 应用易卒中型肾血管性高血压大鼠复制大脑中动脉缺血模型,缺血3 h...
关键词：RT-PA MMP-2 MMP-9 重组组织型纤溶酶原激活剂 基质金属蛋白酶-2 神经源性丝氨酸蛋白酶抑制剂 脑缺血 
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