AXONAL

作品数：154被引量：344H指数：9
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相关领域：医药卫生生物学更多>>
相关作者：彭静吴川杰刘洪波王丽芳张少杰更多>>
相关机构：郑州大学第一附属医院郑州大学吉林大学白求恩第一医院南昌大学第一附属医院更多>>
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Sesquiterpene lactones as potential drugs treating nerve injury
《Neural Regeneration Research》2026年第2期671-672,共2页Philipp Gobrecht Marco Leibinger Dietmar Fischer 
supported by The German Research Foundation.
Traumatic axonal lesions of peripheral nerves disrupt neuronal connections with their targets,resulting in the loss of motor and sensory functions.Despite the peripheral nervous system’s capacity for axonal regrowth,...
关键词：traumatic axonal lesions peripheral nervous system s axonal regrowththis permanent impairements nerve injury peripheral nerves disrupt neuronal connections sesquiterpene lactones 
Pathological axonal enlargement in connection with amyloidosis,lysosome destabilization,and bleeding is a major defect in Alzheimer’s disease
《Neural Regeneration Research》2026年第2期790-799,共10页Hualin Fu Jilong Li Chunlei Zhang Guo Gao Qiqi Ge Xinping Guan Daxiang Cui 
supported by the National Natural Science Foundation of China,No.81472235(to HF);the Shanghai Jiao Tong University Medical and Engineering Project,Nos.YG2021QN53(to HF),YG2017MS71(to HF);the International Cooperation Project of the National Natural Science Foundation of China,No.82020108017(to DC);the Innovation Group Project of the National Natural Science Foundation of China,No.81921002(to DC).
Alzheimer’s disease is a multi-amyloidosis disease characterized by amyloid-βdeposits in brain blood vessels,microaneurysms,and senile plaques.How amyloid-βdeposition affects axon pathology has not been examined ex...
关键词：Alzheimer’s disease amyloid-β AMYLOIDOSIS axonal enlargement hemoglobin hemorrhage lysosome destabilization neuropil thread tau Wallerian degeneration 
Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord被引量：1
《Neural Regeneration Research》2025年第7期2095-2107,共13页Emily A.Hibbard Liwen Zhou Cathy Z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner Dale R.Sengelaub 
supported by the Department of Defense AFIRMⅢW81XWH-20-2-0029 grant subcontract;Lone Star Paralysis gift,UT POC19-1774-13 grant;Neuraptive Therapeutics Inc.26-7724-56 grant;National Institutes of Health R01-NS128086(all to GDB)。
Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically poor.We used a plasmalemmal fusogen,polyethylene g...
关键词：AXOTOMY dorsal horn peripheral nerve injury PLASTICITY polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase 
Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury
《Neural Regeneration Research》2025年第5期1467-1482,共16页Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu 
supported in part by NIH R01 NS100531,R01 NS103481;NIH R21NS130241(to LD);Merit Review Award I01 BX002356,I01 BX003705 from the U.S.Department of Veterans Affairs;Indiana Spinal Cord and Brain Injury Research Foundation(No.19919);Mari Hulman George Endowment Funds(to XMX);Indiana Spinal Cord&Brain Injury Research Fund from ISDH(to NKL and LD)。
Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration...
关键词：axonal regrowth bladder function chondroitinase ABC functional recovery glial scar LENTIVIRUS migration Schwann cell spinal cord injury TRANSPLANTATION 
Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion
《Neural Regeneration Research》2025年第4期1192-1206,共15页Tyler A.Smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner 
supported by grants from the Lone Star Paralysis Foundation,NIH R01NS081063;Department of Defense award W81XWH-19-2-0054 to GDB;supported by University of Wyoming Startup funds,Department of Defense grant W81XWH-17-1-0402;the University of Wyoming Sensory Biology COBRE under National Institutes of Health(NIH)award number 5P20GM121310-02;the National Institute of General Medical Sciences of the NIH under award number P20GM103432 to JSB。
Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal regeneration.Furthermore,such peripher...
关键词：allograft rejection AXOTOMY macrophage MYELIN nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration 
Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination
《Neural Regeneration Research》2025年第2期394-401,共8页Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza 
supported by Catalan Government,Nos.2014SGR344(to JT),2017SGR704(to JT),2021SGR01214(to MAL);MCIN/AEI/10.13039/501100011033/by“ERDF A way of making Europe,”Nos.SAF2015-67143(to JT),PID2019-106332GB-I00(to JT and MAL)and PID2022-141252NB-I00(to MAL).
During the development of the nervous system,there is an overproduction of neurons and synapses.Hebbian competition between neighboring nerve endings and synapses performing different activity levels leads to their el...
关键词：acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB 
A lead role for a“secondary”axonal injury response
《Neural Regeneration Research》2025年第2期469-470,共2页Melissa A.Rudy Trent A.Watkins 
supported by grants from Mission Connect, a project of the TIRR Foundation, the Glaucoma Research Foundation;NIH grants R01NS112691 and R01NS076708 (to TAW)
Stress signaling following axon injury stimulates a transcriptional program for regeneration that might be exploited to promote central nervous system repair.However,this stress response drives neuronal apoptosis in n...
关键词：INJURY AXONAL STRESS 
Glaucomatous retinal ganglion cells:death and protection
《International Journal of Ophthalmology(English edition)》2025年第1期160-167,共8页Na Cui Jun Jia Yuan He 
Supported by National Natural Science Foundation of China(No.82070964);Shaanxi Provincial Outstanding Youth Science Foundation Project(No.2022JC-60);Shaanxi International Science and Technology Cooperation Program Project(No.2024GHYBXM-20);Shaanxi Provincial Education Department Youth Innovation Team Research Project(No.23JP151).
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration,with the characteristic pathological change being death of retinal ganglion cells(RGCs),which ultimately causes visual field loss a...
关键词：GLAUCOMA retinal ganglion cells NEUROPROTECTION progressive death axonal deletion 
Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery
《Neural Regeneration Research》2025年第1期224-233,共10页Yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng Gang Zhang 
supported by the NIH grants,R01 NS111801(to ZGZ);American Heart Association 16SDG29860003(to YZ)。
Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional recovery.Our previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)iso...
关键词：axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke 
A study on the application of diffuse axonal multi-axis general evaluation for braininjury assessment in small overlap barrier crash test
《Chinese Journal of Traumatology》2024年第4期200-210,共11页Zhi Fu Yi Chang Tao Xiong Wen-Kai Gao Kui Li Yu Liu 
This work has been supported by the National Natural ScienceFoundation of China(Grant No.32171305);Natural Science Foundation of Chongqing,China(Grant No.cstc2021jcyj-msxmX0109);Chongqing Technology Innovation and Application Development Project(Grant No.CSTB2023YSZX-JSX0003).
Purpose:Head injury criterion(HIC)companied by a rotation-based metric was widely believed to behelpful for head injury prediction in road traffic accidents.Recently,the Euro-New Car AssessmentProgram utilized a newly...
关键词：Diffuse axonal multi-axis general evaluation Head injury criterion Head injury assessment Small overlap barrier Biomechanical response 
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