LENTIVIRUS

作品数：99被引量：344H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：蔡培强徐林阳运康林月秋汤逊更多>>
相关机构：成都军区昆明总医院中国科学院复旦大学天津医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划上海市自然科学基金国家教育部博士点基金更多>>
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Innovative gene delivery systems for retinal disease therapy
《Neural Regeneration Research》2026年第2期542-552,共11页Hongguang Wu Ling Dong Shibo Jin Yongwang Zhao Lili Zhu 
Hongguang Wu,Both authors contributed equally to this work and share first authorship;Ling Dong,Both authors contributed equally to this work and share first authorship;。
The human retina,a complex and highly specialized structure,includes multiple cell types that work synergistically to generate and transmit visual signals.However,genetic predisposition or age-related degeneration can...
关键词：adeno-associated viruses delivery systems gene delivery gene therapy LENTIVIRUS nanoparticle delivery non-viral delivery retinal disease RETINA small molecular delivery 
Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury
《Neural Regeneration Research》2025年第5期1467-1482,共16页Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu 
supported in part by NIH R01 NS100531,R01 NS103481;NIH R21NS130241(to LD);Merit Review Award I01 BX002356,I01 BX003705 from the U.S.Department of Veterans Affairs;Indiana Spinal Cord and Brain Injury Research Foundation(No.19919);Mari Hulman George Endowment Funds(to XMX);Indiana Spinal Cord&Brain Injury Research Fund from ISDH(to NKL and LD)。
Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration...
关键词：axonal regrowth bladder function chondroitinase ABC functional recovery glial scar LENTIVIRUS migration Schwann cell spinal cord injury TRANSPLANTATION 
Lentivirus-modified hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy:a long-term follow-up pilot study
《Protein & Cell》2025年第1期16-27,共12页Zhao Zhang Hua Jiang Li Huang Sixi Liu Xiaoya Zhou Yun Cai Ming Li Fei Gao Xiaoting Liang Kam-Sze Tsang Guangfu Chen Chui-Yan Ma Yuet-Hung Chai Hongsheng Liu Chen Yang Mo Yang Xiaoling Zhang Shuo Han Xin Du Ling Chen Wuh-Liang Hwu Jiacai Zhuo Qizhou Lian 
supported in part by Poland Fundacja Siepomaga;JS Foundation (Hong Kong);Shenzhen Li Weibo Charity Foundation;Taiwan Rare Disease Foundation。
Metachromatic leukodystrophy(MLD)is an inherited disease caused by a deficiency of the enzyme arylsulfatase A(ARSA).Lentivirus-modified autologous hematopoietic stem cell gene therapy(HSCGT)has recently been approved ...
关键词：HSCGT advanced symptomatic metachromatic leukodystrophy JUVENILE patients safety effcacy 
Lentivirus Transduced T Cell Lines Response to Pro-Inflammatory and Antiviral Cytokines in the Presence of HIV
《Journal of Biosciences and Medicines》2024年第10期222-235,共14页Kevin Ventocilla Daniel Miranda Jr. David Jesse Sanchez 
Various studies have attempted to understand HIV infection under a diverse range of stimulants including cytokine stimulation. Pro-inflammatory cytokines, such as TNF-α, have been shown to reactivate HIV latency by i...
关键词：HIV CYTOKINE INTERFERON Cell TNF 
Effectiveness of chemical inactivation of infectious liquid biological waste:A randomized sample study of research laboratories in Switzerland
《Journal of Biosafety and Biosecurity》2024年第1期16-26,共11页Alina CTeuscher Charlotte Ruhnau Nicole Stöcklin Fabienne Wichmann Evelyn Ilg Hampe Claudia Bagutti 
Laboratory wastewater has been suggested as an important escape route for microorganisms from research environments.Likely reasons for the unintentional release of laboratory organisms are shortcomings in the handling...
关键词：Chemical inactivation Infectious liquid biological waste Lentivirus(HIV-1) ADENOVIRUS 
Host cell restriction factors of equine infectious anemia virus
《Virologica Sinica》2023年第4期485-496,共12页Xue-Feng Wang Xiangmin Zhang Weiwei Ma Jiwei Li Xiaojun Wang 
supported by grants from the National Natural Science Foundation of China (32172831 and 31672578 to XF.W,32170169 to X.W);the Postdoctoral Scientific Research Developmental Fund of Heilongjiang Province (LBH-Q20059 to XF.W);the Central Public-interest Scientific Institution Basal Research Fund (1610302022007 to XF.W).
Equine infectious anemia virus(EIAV)is a member of the lentivirus genus in the Retroviridae family and is considered an animal model for HIV/AIDS research.An attenuated EIAV vaccine,which was successfully developed in...
关键词：Equine infectious anemia virus(EIAV) Restriction factor LENTIVIRUS 
Generation of a tree shrew breast cancer model using lentivirus expressing PIK3CA-H1047R被引量：3
《Zoological Research》2023年第1期94-97,共4页Li Zeng Hong-Yan Zhang Chuan-Yu Yang Zhuo Cheng Qiu-Yun Jiang Yao Luo Yi Li Fu-Bing Li Ce-Shi Chen 
supported by the National Key Research and Development Program of China(2020YFA0112300,2018YFC2000400);National Natural Science Foundation of China(81830087 and U2102203 to C.S.C.,82000817 to F.B.L.);CAS“Light of West China”Program(xbzg-zdsys-201909);Yunnan Fundamental Research Projects(202101AS070050)。
DEAR EDITOR,Breast cancer is the most common malignant tumor in women,posing a serious threat to health. Tree shrews(Tupaia belangeri chinensis) are evolutionarily closer to humans than rodents and are emerging as an ...
关键词：PIK3CA BREAST CANCER 
Neutralizing peripheral circulating IL1β slows the progression of ALS in a lentivirus-infected OPTN^(E478G)mouse model
《Animal Models and Experimental Medicine》2023年第1期18-25,共8页Wen-Bao Hu Xin Wang Zhi-Lin Pang Ran Duan Chun-Gu Hong Zheng-Zhao Liu 
National Natural Science Foundation of China(grant numbers:82172502 and 81974127).
Background:Amyotrophic lateral sclerosis(ALS)is irreversible and fatal within 3-5 years,with limited options for treatment.It is imperative to develop a symptom-based treatment that may increase the survival of ALS pa...
关键词：amyotrophic lateral sclerosis inflammation interleukin 1β NEURODEGENERATION OPTINEURIN 
Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A被引量：2
《World Journal of Gastroenterology》2022年第37期5420-5443,共24页Xian Li Yi-Ru Han Xuefeng Xuefeng Yong-Xiang Ma Guo-Sheng Xing Zhi-Wen Yang Zhen Zhang Lin Shi Xin-Lin Wu 
the National Natural Science Foundation of China,No.81860416 and No.22168028;Inner Mongolia Autonomous Region Grassland Talent Innovation Talent Team Fund,No.2019;Inner Mongolia Natural Science Fund,No.2021MS02005.
BACKGROUND Colorectal cancer(CRC)is one of the most common malignant tumors worldwide.The identification of novel diagnostic and prognostic biomarkers for CRC is a key research imperative.Immunohistochemical analysis ...
关键词：Colorectal cancer Centromere protein K Bioinformatics analysis Lentivirus-mediated short hairpin RNA interference Cullin 4A 
Lentivirus-Mediated Short Hairpin RNA for Follistatin Downregulation Suppresses Tumor Progression in Hypopharyngeal Carcinoma被引量：1
《Current Medical Science》2022年第4期832-840,共9页Liang GE Shao-feng LIU 
supported by the Project of Young and Middle-aged Scientific Research Fund of Wannan Medical College(No.WK2019F11).
Objective:Follistatin(FST)inhibits the action of activin by interfering with the binding of activin to its receptor.Although the prognostic value of FST in various cancers has been investigated previously,studies rare...
关键词：FOLLISTATIN hypopharyngeal carcinoma migration INVASION PROLIFERATION apoptosis 
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