Host cell restriction factors of equine infectious anemia virus  

作　　者：Xue-Feng Wang Xiangmin Zhang Weiwei Ma Jiwei Li Xiaojun Wang 

机构地区：[1]State Key Laboratory for Animal Disease Control and Prevention,Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences,Harbin 150069,China

出　　处：《Virologica Sinica》2023年第4期485-496,共12页中国病毒学（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (32172831 and 31672578 to XF.W,32170169 to X.W);the Postdoctoral Scientific Research Developmental Fund of Heilongjiang Province (LBH-Q20059 to XF.W);the Central Public-interest Scientific Institution Basal Research Fund (1610302022007 to XF.W).

摘　　要：Equine infectious anemia virus(EIAV)is a member of the lentivirus genus in the Retroviridae family and is considered an animal model for HIV/AIDS research.An attenuated EIAV vaccine,which was successfully developed in the 1970s by classical serial passage techniques,is the first and only lentivirus vaccine that has been widely used to date.Restriction factors are cellular proteins that provide an early line of defense against viral replication and spread by interfering with various critical steps in the viral replication cycle.However,viruses have evolved specific mechanisms to overcome these host barriers through adaptation.The battle between the viruses and restriction factors is actually a natural part of the viral replication process,which has been well studied in human immunodeficiency virus type 1(HIV-1).EIAV has the simplest genome composition of all lentiviruses,making it an intriguing subject for understanding how the virus employs its limited viral proteins to overcome restriction factors.In this review,we summarize the current literature on the interactions between equine restriction factors and EIAV.The features of equine restriction factors and the mechanisms by which the EIAV counteract the restriction suggest that lentiviruses employ diverse strategies to counteract innate immune restrictions.In addition,we present our insights on whether restriction factors induce alterations in the phenotype of the attenuated EIAV vaccine.

关 键 词：Equine infectious anemia virus(EIAV) Restriction factor LENTIVIRUS 

分 类 号：S852.65[农业科学—基础兽医学]