云南高校图书馆联盟文献共享服务平台- OPTINEURIN

OPTINEURIN: 作品数：11被引量：13H指数：2; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：杨波何俏军翁勤洁杨丽君王佳颖更多>>; 相关机构：浙江大学哈尔滨医科大学中国科学院大学第三军医大学大坪医院更多>>; 相关期刊：《Neuroscience & Medicine》《国际眼科杂志》《美国医学会眼科杂志（中文版）》《病毒学报》更多>>; 相关基金：国家自然科学基金更多>>

Roles of Optineurin and Extracellular Vesicles in Glaucomatous Retinal Cell Loss被引量：2: 《Current Medical Science》2023年第2期367-375,共9页Chao-ye DUAN Wan-lin FAN Fei CHEN; supported by grants from the Wuhan Science and Technology Bureau(No.02.07.17040008.05);the Fundamental Research Funds for the Central Universities(2042020kf0099);the Opening Foundation of Hubei Key Laboratory(No.2021KFY054).; Objective To explore the role of extracellular vesicles(EVs)in the pathogenesis of glaucoma caused by E50K mutation.Methods A photoreceptor cell line,RGC-5,was transfected with empty plasmids and plasmids expressing w...; 关键词：E50K mutation extracellular vesicles GLAUCOMA OPTINEURIN RGC-5 photoreceptor cell line

Presence of Rare Variants is Associated with Poorer Survival in Chinese Patients with Amyotrophic Lateral Sclerosis: 《Phenomics》2023年第2期167-181,共15页Siqi Dong Xianhong Yin Kun Wang Wenbo Yang Jiatong Li Yi Wang Yanni Zhou Xiaoni Liu Jiucun Wang Xiangjun Chen; This work was supported by 2020 Central Transfer Payment Medical Siege Institutions Capacity Building Project(National and Provincial Multi-scientific Cooperation Diagnosis and Treatment of Major Diseases Capacity Building Project);Shanghai Fudan University Education Development Foundation and State Key Laboratory of Genetic Engineering,Human Phenome Institute,Zhangjiang Fudan International Innovation Center,Fudan University;Shanghai Municipal Science and Technology Major Project 2017HZDZX01.; Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disorder with phenotypic and genetic heterogeneity.Recent studies have suggested an oligogenic basis of ALS,in which the co-occurrence of two or more gene...; 关键词：Amyotrophic lateral sclerosis Oligogenic inheritance SURVIVAL Superoxide dismutase 1 TANK-binding kinase 1 OPTINEURIN

Neutralizing peripheral circulating IL1β slows the progression of ALS in a lentivirus-infected OPTN^(E478G)mouse model: 《Animal Models and Experimental Medicine》2023年第1期18-25,共8页Wen-Bao Hu Xin Wang Zhi-Lin Pang Ran Duan Chun-Gu Hong Zheng-Zhao Liu; National Natural Science Foundation of China(grant numbers:82172502 and 81974127).; Background:Amyotrophic lateral sclerosis(ALS)is irreversible and fatal within 3-5 years,with limited options for treatment.It is imperative to develop a symptom-based treatment that may increase the survival of ALS pa...; 关键词：amyotrophic lateral sclerosis inflammation interleukin 1β NEURODEGENERATION OPTINEURIN

线粒体自噬进程及其受病毒感染的影响被引量：2: 《病毒学报》2021年第3期748-754,共7页聂欢欢邱坚发张学艳王燕; 国家自然科学基金面上项目(项目号:81772188),题目:B组柯萨奇病毒干扰心肌细胞线粒体稳态的机制研究。; 线粒体自噬(mitophagy)属于巨自噬的范畴,即受损线粒体被一种双层膜结构(如粗面内质网的无核糖体附着区脱落的双层膜)包裹后形成自噬小体(autophagosome),接着自噬小体的外膜与溶酶体膜融合,底物蛋白进入溶酶体,最终被各类水解酶降解的...; 关键词：线粒体自噬 PINK1 PARKIN Optineurin(OPTN) B组柯萨奇病毒(CVB)

Association between the M98K variant of the OPTN gene and the risk for primary open angle glaucoma:an updated meta-analysis: 《Annals of Eye Science》2021年第2期32-44,共13页Congcong Guo Xiaowei Yu Dandan Zhang Zhenni Zhao Jiamin Zhang Miao Zhang Nannan Sun Zhigang Fan; This work was supported by Major Project of National Natural Science Foundation of China(NSFC)-Guangdong Province Joint Fund(grant number 3030902113080);the Science and Technology Planning Project of Guangdong Province(grant number 303090100502050-18);Guangzhou Science and Technology Plan Project(grant number 2018-1202-SF-0019);Research Funds of the State Key Laboratory of Ophthalmology(grant number 30306020240020153,30306020240020192,3030902113058,3030902113118,PT1001022);Fundamental Research Funds of Sun Yat-sen University(grant number 16ykjc31).; Background:The association between optineurin(OPTN)M98K variant and primary open angle glaucoma(POAG)has been widely investigated.However,the results remain controversial among published meta-analyses.Therefore,we con...; 关键词：M98K META optineurin(OPTN) primary open angle glaucoma(POAG)

Identification of the Stress Which Causes Optineurin Aggregation: 《Neuroscience & Medicine》2019年第2期150-161,共12页Satoshi Inagaki Michinori Funato Junko Seki Chizuru Kawase Kazuki Ohuchi Shiori Ando Shinsuke Nakamura Masamitsu Shimazawa Hideo Kaneko Hideaki Hara; Glaucoma is a common neurodegenerative disease that can cause blindness and occurs worldwide. Currently, lowering intraocular pressure is the only therapy available to protect retinal ganglion cells (RGCs). However, t...; 关键词：GLAUCOMA Induced PLURIPOTENT Stem CELLS Retinal GANGLION CELLS OPTINEURIN Protein AGGREGATION

Mitochondrial quality control in amyotrophic lateral sclerosis：towards a common pathway？被引量：5: 《Neural Regeneration Research》2017年第7期1052-1061,共10页Bilal Khalil Jean-Charles Liévens; Amyotrophic lateral sclerosis（ALS）is a devastating neurodegenerative disorder characterized by loss of upper and lower motor neurons.Different mechanisms contribute to the disease initiation and progression,includin...; 关键词：C9orf72 FUS SOD1 OPTINEURIN PARKIN PGC-1α PINK1 TDP-43 proteinopathies TBK1 VCP

青光眼致病基因OPTN在大鼠光感受器细胞内的表达被引量：1: 《解剖科学进展》2013年第3期268-271,共4页王春霞杨德琪赵宇于紫燕阎启昌张劲松; 国家自然科学基金资助项目(No.81000402); 目的观察OPTN在大鼠视网膜光感受器细胞内的表达及定位,探讨OPTN和NRL(neural retina leucine zipper)两蛋白相互的作用。方法制备正常Wistar大鼠的视网膜冷冻切片,用抗OPTN抗体、抗NRL抗体和抗CRX抗体分别进行多重免疫荧光染色。结果...; 关键词：OPTINEURIN 免疫荧光染色光感受器大鼠

Optineurin在POAG发病机制中作用的最新研究被引量：1: 《华南国防医学杂志》2007年第5期67-69,共3页曾艳彩陈飞; 关键词：青光眼 OPTN 发病机制

成人发病的原发性开角型青光眼患者中optineurin突变与疾病间缺少相关性: 《美国医学会眼科杂志（中文版）》2004年第2期125-125,共1页JaneyL.Wiggs JosetteAuguste R.RandAllingham JasonD.Flor MargaretA.Pericak-Vance kathrynRogers KarenR.LaRocque FeliciaL.Graham BobBroomer ElizabethDelBono JonathanL.Haires MichaelHauser 齐越; 关键词：成人原发性开角型青光眼 OPTINEURIN 基因突变相关性

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