Generation of a tree shrew breast cancer model using lentivirus expressing PIK3CA-H1047R  

作　　者：Li Zeng Hong-Yan Zhang Chuan-Yu Yang Zhuo Cheng Qiu-Yun Jiang Yao Luo Yi Li Fu-Bing Li Ce-Shi Chen 

机构地区：[1]Key Laboratory of Animal Models and Human Disease Mechanisms,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650223,China [2]Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming,Yunnan 650500,China [3]Lester and Sue Smith Breast Center,Baylor College of Medicine,Houston TX 77030,USA [4]Academy of Biomedical Engineering,Kunming Medical University,Kunming,Yunnan 650500,China [5]Third Affiliated Hospital,Kunming Medical University,Kunming,Yunnan 650118,China [6]Kunming College of Life Science,University of Chinese Academy of Sciences,Kunming,Yunnan 650204,China

出　　处：《Zoological Research》2023年第1期94-97,共4页动物学研究（英文）

基　　金：supported by the National Key Research and Development Program of China(2020YFA0112300,2018YFC2000400);National Natural Science Foundation of China(81830087 and U2102203 to C.S.C.,82000817 to F.B.L.);CAS“Light of West China”Program(xbzg-zdsys-201909);Yunnan Fundamental Research Projects(202101AS070050)。

摘　　要：DEAR EDITOR,Breast cancer is the most common malignant tumor in women,posing a serious threat to health. Tree shrews(Tupaia belangeri chinensis) are evolutionarily closer to humans than rodents and are emerging as an attractive experimental animal model for breast cancer. The PIK3CA gene is frequently mutated in both human and tree shrew breast tumors. Herein, we effectively overexpressed PIK3CA-H1047R in the mammary epithelial cells of tree shrews using a lentivirus to induce breast tumors.

关 键 词：PIK3CA BREAST CANCER 

分 类 号：Q95[生物学—动物学]